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RPL32 ribosomal protein L32 [ Homo sapiens (human) ]

Gene ID: 6161, updated on 4-Apr-2021

Summary

Official Symbol
RPL32provided by HGNC
Official Full Name
ribosomal protein L32provided by HGNC
Primary source
HGNC:HGNC:10336
See related
Ensembl:ENSG00000144713
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L32; PP9932
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L32E family of ribosomal proteins. It is located in the cytoplasm. Although some studies have mapped this gene to 3q13.3-q21, it is believed to map to 3p25-p24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 460.1), bone marrow (RPKM 265.8) and 25 other tissues See more
Orthologs
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Genomic context

See RPL32 in Genome Data Viewer
Location:
3p25.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (12834485..12841582, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (12875984..12883081, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 40 Neighboring gene keratin 18 pseudogene 17 Neighboring gene cullin associated and neddylation dissociated 2 (putative) Neighboring gene small nucleolar RNA, H/ACA box 7A Neighboring gene microtubule affinity regulating kinase 4 pseudogene Neighboring gene microtubule affinity regulating kinase 3 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, ribosomal protein L32 (RPL32), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
cytoplasmic translation IDA
Inferred from Direct Assay
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
polysomal ribosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
60S ribosomal protein L32
Names
large ribosomal subunit protein eL32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000994.4NP_000985.1  60S ribosomal protein L32

    See identical proteins and their annotated locations for NP_000985.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC034198, CA436299, CF124158
    Consensus CDS
    CCDS2614.1
    UniProtKB/Swiss-Prot
    P62910
    UniProtKB/TrEMBL
    A0A024R2G7
    Related
    ENSP00000416429.2, ENST00000429711.7
    Conserved Domains (1) summary
    pfam01655
    Location:17124
    Ribosomal_L32e; Ribosomal protein L32
  2. NM_001007073.1NP_001007074.1  60S ribosomal protein L32

    See identical proteins and their annotated locations for NP_001007074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional segment in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC034198, BQ068496, CA436299, CF124158
    Consensus CDS
    CCDS2614.1
    UniProtKB/Swiss-Prot
    P62910
    UniProtKB/TrEMBL
    A0A024R2G7
    Related
    ENSP00000380158.1, ENST00000396957.5
    Conserved Domains (1) summary
    pfam01655
    Location:17124
    Ribosomal_L32e; Ribosomal protein L32
  3. NM_001007074.1NP_001007075.1  60S ribosomal protein L32

    See identical proteins and their annotated locations for NP_001007075.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a 5' exon but has an alternate segment in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC034198, BC070209, BF960792, CA436299
    Consensus CDS
    CCDS2614.1
    UniProtKB/Swiss-Prot
    P62910
    UniProtKB/TrEMBL
    A0A024R2G7
    Related
    ENSP00000380156.2, ENST00000396953.6
    Conserved Domains (1) summary
    pfam01655
    Location:17124
    Ribosomal_L32e; Ribosomal protein L32

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    12834485..12841582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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