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RPL31 ribosomal protein L31 [ Homo sapiens (human) ]

Gene ID: 6160, updated on 9-Aug-2020

Summary

Official Symbol
RPL31provided by HGNC
Official Full Name
ribosomal protein L31provided by HGNC
Primary source
HGNC:HGNC:10334
See related
Ensembl:ENSG00000071082 MIM:617415
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L31
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L31E family of ribosomal proteins. It is located in the cytoplasm. Higher levels of expression of this gene in familial adenomatous polyps compared to matched normal tissues have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 450.2), bone marrow (RPKM 284.8) and 25 other tissues See more
Orthologs

Genomic context

See RPL31 in Genome Data Viewer
Location:
2q11.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (101002229..101019693)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101618691..101636155)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373508 Neighboring gene neuronal PAS domain protein 2 Neighboring gene NPAS2 antisense RNA 1 Neighboring gene ubiquitin specific peptidase 15 pseudogene Neighboring gene uncharacterized LOC105373510 Neighboring gene TBC1 domain family member 8 Neighboring gene BBSome interacting protein 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC88191

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic translation IDA
Inferred from Direct Assay
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
60S ribosomal protein L31
Names
large ribosomal subunit protein eL31

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000993.5NP_000984.1  60S ribosomal protein L31 isoform 1

    See identical proteins and their annotated locations for NP_000984.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
    Source sequence(s)
    AC016738, BC017343, BC070373, DA869102
    Consensus CDS
    CCDS2049.1
    UniProtKB/Swiss-Prot
    P62899
    Related
    ENSP00000264258.3, ENST00000264258.8
    Conserved Domains (1) summary
    pfam01198
    Location:20100
    Ribosomal_L31e; Ribosomal protein L31e
  2. NM_001098577.2NP_001092047.1  60S ribosomal protein L31 isoform 2

    See identical proteins and their annotated locations for NP_001092047.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate terminal exon; the resulting isoform (2) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BE564858, CN269912, CN269915, DA869102
    Consensus CDS
    CCDS46373.1
    UniProtKB/Swiss-Prot
    P62899
    Related
    ENSP00000386717.3, ENST00000409028.8
    Conserved Domains (1) summary
    pfam01198
    Location:19100
    Ribosomal_L31e; Ribosomal protein L31e
  3. NM_001099693.1NP_001093163.1  60S ribosomal protein L31 isoform 3

    See identical proteins and their annotated locations for NP_001093163.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an unspliced 3' sequence compared to variant 1; the resulting isoform (3) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC001663, BC070210, DA869102
    Consensus CDS
    CCDS46374.1
    UniProtKB/Swiss-Prot
    P62899
    Related
    ENSP00000387163.3, ENST00000409320.7
    Conserved Domains (1) summary
    pfam01198
    Location:20100
    Ribosomal_L31e; Ribosomal protein L31e

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    101002229..101019693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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