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RPL29 ribosomal protein L29 [ Homo sapiens (human) ]

Gene ID: 6159, updated on 5-Jul-2020

Summary

Official Symbol
RPL29provided by HGNC
Official Full Name
ribosomal protein L29provided by HGNC
Primary source
HGNC:HGNC:10331
See related
Ensembl:ENSG00000162244 MIM:601832
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIP; L29; HUMRPL29; RPL29P10; RPL29_3_370
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29E family of ribosomal proteins. The protein is also a peripheral membrane protein expressed on the cell surface that directly binds heparin. Although this gene was previously reported to map to 3q29-qter, it is believed that it is located at 3p21.3-p21.2. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 1016.6), bone marrow (RPKM 597.0) and 25 other tissues See more
Orthologs

Genomic context

See RPL29 in Genome Data Viewer
Location:
3p21.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (51993522..51995895, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (52027644..52029958, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ABHD14A-ACY1 readthrough Neighboring gene abhydrolase domain containing 14A Neighboring gene aminoacylase 1 Neighboring gene uncharacterized LOC105377088 Neighboring gene dual specificity phosphatase 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L29 (RPL29), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L29 (RPL29), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L29 (RPL29), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag HIV-1 Gag interacts with RPL29 as demonstrated by proximity dependent biotinylation proteomics PubMed
gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L29 (RPL29), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of ribosomal protein L29 (RPL29) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC88589

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
cadherin binding HDA PubMed 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
embryo implantation TAS
Traceable Author Statement
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 

General protein information

Preferred Names
60S ribosomal protein L29
Names
HP/HS-interacting protein
cell surface heparin-binding protein HIP
heparin/heparan sulfate-binding protein
heparin/heparan sulfate-interacting protein
large ribosomal subunit protein eL29
ribosomal protein YL43 homologue

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000992.3NP_000983.1  60S ribosomal protein L29

    See identical proteins and their annotated locations for NP_000983.1

    Status: REVIEWED

    Source sequence(s)
    AC115284, BC008926
    Consensus CDS
    CCDS2845.1
    UniProtKB/Swiss-Prot
    P47914
    Related
    ENSP00000294189.4, ENST00000294189.11
    Conserved Domains (1) summary
    pfam01779
    Location:442
    Ribosomal_L29e; Ribosomal L29e protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    51993522..51995895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453698.1XP_024309466.1  60S ribosomal protein L29 isoform X1

    Conserved Domains (1) summary
    pfam01779
    Location:2351
    Ribosomal_L29e; Ribosomal L29e protein family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_010644.1: Suppressed sequence

    Description
    NG_010644.1: This RefSeq was permanently suppressed because it actually represents the 3'' exon of the functional gene.
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