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CBLC Cbl proto-oncogene C [ Bos taurus (domestic cattle) ]

Gene ID: 615866, updated on 5-Sep-2025
Official Symbol
CBLCprovided by VGNC
Official Full Name
Cbl proto-oncogene Cprovided by VGNC
Primary source
VGNC:VGNC:26810
See related
BGD:BT14926; EnsemblRapid:ENSBTAG00070018428
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See CBLC in Genome Data Viewer
Location:
chromosome: 18
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (52541241..52556911)

Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107131434 Neighboring gene BCL3 transcription coactivator Neighboring gene uncharacterized LOC132342865 Neighboring gene basal cell adhesion molecule Neighboring gene nectin cell adhesion molecule 2 Neighboring gene large ribosomal subunit protein eL15-like

Genomic Sequence:
NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Processing of glutathionylcobalamin by a bovine B12 trafficking chaperone bCblC involved in intracellular B12 metabolism. Jeong J, et al. Biochem Biophys Res Commun, 2014 Jan 3. PMID 24286755
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. bCblC, a bovine B12 trafficking chaperone, catalyzes elimination of the glutathione ligand from GSCbl by using the reduced form of glutathione (GSH).
    Title: Processing of glutathionylcobalamin by a bovine B12 trafficking chaperone bCblC involved in intracellular B12 metabolism.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
E3 ubiquitin-protein ligase CBL-C
Names
Cas-Br-M (murine) ecotropic retroviral transforming sequence c
NP_001094718.1
XP_005219395.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101248.2 → NP_001094718.1  E3 ubiquitin-protein ligase CBL-C

    See identical proteins and their annotated locations for NP_001094718.1

    Status: PROVISIONAL

    Source sequence(s)
    BC149567
    UniProtKB/TrEMBL
    A6QPZ5
    Related
    ENSBTAP00070024869.1, ENSBTAT00070041661.1
    Conserved Domains (4) summary
    cd09920
    Location:225 → 321
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:350 → 392
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam02262
    Location:15 → 144
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:148 → 231
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    52541241..52556911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005219338.5 → XP_005219395.1  E3 ubiquitin-protein ligase CBL-C isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MMZ4
    Related
    ENSBTAP00070024876.1, ENSBTAT00070041672.1
    Conserved Domains (4) summary
    cd09920
    Location:225 → 321
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:350 → 392
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam02262
    Location:15 → 144
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:148 → 231
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
Nucleotide Protein Strain
Heading Accession and Version

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