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RPL27A ribosomal protein L27a [ Homo sapiens (human) ]

Gene ID: 6157, updated on 5-Sep-2021


Official Symbol
RPL27Aprovided by HGNC
Official Full Name
ribosomal protein L27aprovided by HGNC
Primary source
See related
Ensembl:ENSG00000166441 MIM:603637
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008]
Ubiquitous expression in bone marrow (RPKM 103.5), ovary (RPKM 92.6) and 25 other tissues See more
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Genomic context

See RPL27A in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (8682792..8689872)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (8704339..8711419)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376536 Neighboring gene LIM domain only 1 Neighboring gene serine/threonine kinase 33 Neighboring gene tripartite motif containing 66 Neighboring gene Sharpr-MPRA regulatory region 3983 Neighboring gene uncharacterized LOC107984308 Neighboring gene small nucleolar RNA, H/ACA box 3A Neighboring gene small nucleolar RNA, H/ACA box 3B Neighboring gene DENN domain containing 2B Neighboring gene uncharacterized LOC105376539 Neighboring gene uncharacterized LOC102724784

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


Associated conditions

Description Tests
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
GeneReviews: Not available
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with RPL27AP6 as demonstrated by proximity dependent biotinylation proteomics PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • FLJ43464, MGC10850, MGC17878, MGC87238

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
involved_in translation NAS
Non-traceable Author Statement
more info
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
located_in cytosol TAS
Traceable Author Statement
more info
part_of cytosolic large ribosomal subunit HDA PubMed 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
located_in membrane HDA PubMed 

General protein information

Preferred Names
60S ribosomal protein L27a
large ribosomal subunit protein uL15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000990.5NP_000981.1  60S ribosomal protein L27a

    See identical proteins and their annotated locations for NP_000981.1

    Status: REVIEWED

    Source sequence(s)
    AC091053, AI809856, BC004284, BC020169
    Consensus CDS
    ENSP00000346015.5, ENST00000314138.11
    Conserved Domains (1) summary
    PTZ00160; 60S ribosomal protein L27a; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032650.1: Suppressed sequence

    NM_032650.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
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