Format

Send to:

Choose Destination

RPL26 ribosomal protein L26 [ Homo sapiens (human) ]

Gene ID: 6154, updated on 5-Jul-2020

Summary

Official Symbol
RPL26provided by HGNC
Official Full Name
ribosomal protein L26provided by HGNC
Primary source
HGNC:HGNC:10327
See related
Ensembl:ENSG00000161970 MIM:603704
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L26; DBA11
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Expression
Ubiquitous expression in ovary (RPKM 654.6), bone marrow (RPKM 461.4) and 25 other tissues See more
Orthologs

Genomic context

See RPL26 in Genome Data Viewer
Location:
17p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (8377516..8383193, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8280834..8286565, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene outer dense fiber of sperm tails 4 Neighboring gene uncharacterized LOC100128288 Neighboring gene KRAB-A domain containing 2 Neighboring gene ring finger protein 222 Neighboring gene Sharpr-MPRA regulatory region 12124

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
nucleocapsid gag HIV-1 NC co-localizes with ribosomal protein RPL26 in the cytoplasm PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA 5'-UTR binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
cellular response to UV IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to gamma radiation IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
rRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of translation involved in cellular response to UV IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic ribosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
60S ribosomal protein L26
Names
large ribosomal subunit protein uL24

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031989.1 RefSeqGene

    Range
    5055..10732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1125

mRNA and Protein(s)

  1. NM_000987.5NP_000978.1  60S ribosomal protein L26

    See identical proteins and their annotated locations for NP_000978.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK311804, BC071664, BM928617
    Consensus CDS
    CCDS11142.1
    UniProtKB/Swiss-Prot
    P61254
    Related
    ENSP00000498177.1, ENST00000648839.1
    Conserved Domains (1) summary
    pfam16906
    Location:8122
    Ribosomal_L26; Ribosomal proteins L26 eukaryotic, L24P archaeal
  2. NM_001315530.2NP_001302459.1  60S ribosomal protein L26

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC135178, BC071664, BI603704, BM928617
    Consensus CDS
    CCDS11142.1
    UniProtKB/Swiss-Prot
    P61254
    Related
    ENSP00000463784.1, ENST00000584164.6
    Conserved Domains (1) summary
    pfam16906
    Location:8122
    Ribosomal_L26; Ribosomal proteins L26 eukaryotic, L24P archaeal
  3. NM_001315531.2NP_001302460.1  60S ribosomal protein L26

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC135178, BC071664, BI596427, BM928617
    Consensus CDS
    CCDS11142.1
    UniProtKB/Swiss-Prot
    P61254
    Related
    ENSP00000463470.1, ENST00000582556.5
    Conserved Domains (1) summary
    pfam16906
    Location:8122
    Ribosomal_L26; Ribosomal proteins L26 eukaryotic, L24P archaeal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    8377516..8383193 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center