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RPL24 ribosomal protein L24 [ Homo sapiens (human) ]

Gene ID: 6152, updated on 17-Jun-2024

Summary

Official Symbol
RPL24provided by HGNC
Official Full Name
ribosomal protein L24provided by HGNC
Primary source
HGNC:HGNC:10325
See related
Ensembl:ENSG00000114391 MIM:604180; AllianceGenome:HGNC:10325
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L24; eL24; HEL-S-310
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24E family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as ribosomal protein L30 because the encoded protein shares amino acid identity with the L30 ribosomal proteins from S. cerevisiae; however, its official name is ribosomal protein L24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 885.8), endometrium (RPKM 419.1) and 25 other tissues See more
Orthologs
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Genomic context

See RPL24 in Genome Data Viewer
Location:
3q12.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (101681091..101686718, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (104393768..104399383, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (101399935..101405562, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 11 Neighboring gene RNY1 pseudogene 12 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:101392720-101393220 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:101395114-101395668 Neighboring gene endogenous retrovirus group K member 5 Gag polyprotein Neighboring gene ZBTB11 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20173 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:101405139-101406338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:101406769-101407322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:101407323-101407876 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:101418343-101419102 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:101419863-101420622 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:101420623-101421381 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:101421445-101422644 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:101422701-101423652 Neighboring gene uncharacterized LOC124909402 Neighboring gene PDCL3 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L24 (RPL24), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L24 (RPL24), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L24 (RPL24), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L24 (RPL24), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables cadherin binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cytoplasmic translation IC
Inferred by Curator
more info
PubMed 
involved_in cytoplasmic translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in exit from mitosis IEA
Inferred from Electronic Annotation
more info
 
involved_in optic nerve development IEA
Inferred from Electronic Annotation
more info
 
involved_in retina development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
involved_in retinal ganglion cell axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of cytosolic large ribosomal subunit HDA PubMed 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 
located_in membrane HDA PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
large ribosomal subunit protein eL24
Names
60S ribosomal protein L24
60S ribosomal protein L30
epididymis secretory protein Li 310
ribosomal protein L30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000986.4NP_000977.1  large ribosomal subunit protein eL24

    See identical proteins and their annotated locations for NP_000977.1

    Status: REVIEWED

    Source sequence(s)
    BU754101, CD513036, M94314
    Consensus CDS
    CCDS33809.1
    UniProtKB/Swiss-Prot
    B2R4Y3, P38663, P83731, Q6IBS3
    UniProtKB/TrEMBL
    A0A994J4A5, V9HW01
    Related
    ENSP00000377640.3, ENST00000394077.8
    Conserved Domains (1) summary
    pfam01246
    Location:264
    Ribosomal_L24e; Ribosomal protein L24e

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    101681091..101686718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    104393768..104399383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)