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PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha [ Bos taurus (cattle) ]

Gene ID: 615074, updated on 17-Sep-2018

Summary

Official Symbol
PRKAR1Aprovided by VGNC
Official Full Name
protein kinase cAMP-dependent type I regulatory subunit alphaprovided by VGNC
Primary source
VGNC:VGNC:33324
See related
BGD:BT21442; Ensembl:ENSBTAG00000008621
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs

Genomic context

See PRKAR1A in Genome Data Viewer
Location:
chromosome: 19
Exon count:
12
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 19 NC_037346.1 (61702463..61718972, complement)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 19 AC_000176.1 (62317496..62328902, complement)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112442739 Neighboring gene uncharacterized LOC107131549 Neighboring gene uncharacterized LOC112442740 Neighboring gene FAM20A, golgi associated secretory pathway pseudokinase Neighboring gene uncharacterized LOC112442741 Neighboring gene WD repeat domain, phosphoinositide interacting 1 Neighboring gene arylsulfatase G

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cAMP binding IEA
Inferred from Electronic Annotation
more info
 
cAMP-dependent protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
cAMP-dependent protein kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase A catalytic subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
mesoderm formation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of activated T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cAMP-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
sarcomere organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axoneme IEA
Inferred from Electronic Annotation
more info
 
cAMP-dependent protein kinase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
immunological synapse IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
nucleotide-activated protein kinase complex IEA
Inferred from Electronic Annotation
more info
 
plasma membrane raft IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cAMP-dependent protein kinase type I-alpha regulatory subunit
Names
cAMP-dependent protein kinase, regulatory subunit alpha 1
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
NP_001069826.1
XP_024836190.1
XP_024836191.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076358.1NP_001069826.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

    See identical proteins and their annotated locations for NP_001069826.1

    Status: PROVISIONAL

    Source sequence(s)
    BC118242
    UniProtKB/Swiss-Prot
    P00514
    Related
    ENSBTAP00000011371.5, ENSBTAT00000011371.5
    Conserved Domains (2) summary
    cd12101
    Location:1362
    DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:254369
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    61702463..61718972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024980422.1XP_024836190.1  cAMP-dependent protein kinase type I-alpha regulatory subunit isoform X1

    Conserved Domains (2) summary
    cd12101
    Location:1362
    DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:254369
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  2. XM_024980423.1XP_024836191.1  cAMP-dependent protein kinase type I-alpha regulatory subunit isoform X1

    Conserved Domains (2) summary
    cd12101
    Location:1362
    DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:254369
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
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