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PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha [ Bos taurus (domestic cattle) ]

Gene ID: 615074, updated on 5-Sep-2025
Official Symbol
PRKAR1Aprovided by VGNC
Official Full Name
protein kinase cAMP-dependent type I regulatory subunit alphaprovided by VGNC
Primary source
VGNC:VGNC:33324
See related
BGD:BT21442; EnsemblRapid:ENSBTAG00070007943
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See PRKAR1A in Genome Data Viewer
Location:
chromosome: 19
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (61702463..61718911, complement)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107131549 Neighboring gene FAM20A golgi associated secretory pathway pseudokinase Neighboring gene WD repeat domain, phosphoinositide interacting 1 Neighboring gene arylsulfatase G Neighboring gene solute carrier family 16 member 6

Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations. Jafari N, et al. Proc Natl Acad Sci U S A, 2021 May 25. PMID 34006641, Free PMC Article
  2. Isolation of a cDNA clone for the type I regulatory subunit of bovine cAMP-dependent protein kinase. Lee DC, et al. Proc Natl Acad Sci U S A, 1983 Jun. PMID 6190178, Free PMC Article
  3. Amino acid sequence of the regulatory subunit of bovine type I adenosine cyclic 3',5'-phosphate dependent protein kinase. Titani K, et al. Biochemistry, 1984 Aug 28. PMID 6487597
  4. Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains. Su Y, et al. Science, 1995 Aug 11. PMID 7638597
  5. Thermodynamic analysis of protein kinase A Ialpha activation. Rogacheva ON, et al. Biochemistry (Mosc), 2010 Feb. PMID 20367611

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations.
    Title: Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations.
  2. Data suggest that enzyme activation by cAMP involves highly stable conformation of Prkar1a as it binds to Prkaca; glycine residue, G235, appears to function as hinge in B/C helix conserved in Prkar1a; this "Flipback" conformation plays role in cAMP association to A domain of Prkar1a. (Prkar1a = cyclic AMP-dependent protein kinase RIalpha subunit; Prkaca = cyclic AMP-dependent protein kinase catalytic subunit)
    Title: Molecular Simulations Reveal an Unresolved Conformation of the Type IA Protein Kinase A Regulatory Subunit and Suggest Its Role in the cAMP Regulatory Mechanism.
  3. Data suggest PRKAR1A contains two structurally homologous cAMP-binding domains that exhibit marked differences in dynamic profiles in activation/inhibition of Prkaca; conservation of structure does not necessarily imply conservation of dynamics.
    Title: Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα.
  4. Thermodynamic analysis of protein kinase A (PKA) Ialpha activation was performed using Quantum 3.3.0 docking software and a Gaussian 03W quantum mechanical computational package.
    Title: Thermodynamic analysis of protein kinase A Ialpha activation.
  5. Results describe the structures of the protein kinase A RIalpha subunit D/D domain alone and in complex with D-AKAP2.
    Title: Structure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity.
  6. Data show that RSK1 regulates PKAc activity in a cAMP-independent manner, and PKARIalpha by associating with RSK1 regulates its activation and its biological functions.
    Title: p90 ribosomal S6 kinase 1 (RSK1) and the catalytic subunit of protein kinase A (PKA) compete for binding the pseudosubstrate region of PKAR1alpha: role in the regulation of PKA and RSK1 activities.
  7. the PKA RIalpha subunit dynamic C helix mediates isoform-specific domain reorganization upon C subunit binding
    Title: The conformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding.
  8. angle X-ray scattering studies indicate RIalpha, RIIalpha, and RIIbeta homodimers differ markedly in overall shape despite extensive sequence homology and similar molecular masses;cAMP binding does not cause large conformational changes(Prkar1a, Prkar2a)
    Title: Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase A regulatory subunit homodimers: role of the linker regions.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cAMP-dependent protein kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of cAMP-dependent protein kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
cAMP-dependent protein kinase type I-alpha regulatory subunit
Names
cAMP-dependent protein kinase, regulatory subunit alpha 1
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
NP_001069826.1
XP_024836190.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076358.1 → NP_001069826.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

    See identical proteins and their annotated locations for NP_001069826.1

    Status: PROVISIONAL

    Source sequence(s)
    BC118242
    UniProtKB/Swiss-Prot
    A5D9F4, P00514, Q17QP8
    UniProtKB/TrEMBL
    A0A3Q1MBY4
    Related
    ENSBTAP00070010449.1, ENSBTAT00070017909.1
    Conserved Domains (2) summary
    cd12101
    Location:13 → 62
    DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:254 → 369
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    61702463..61718911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024980422.2 → XP_024836190.1  cAMP-dependent protein kinase type I-alpha regulatory subunit isoform X1

    UniProtKB/Swiss-Prot
    A5D9F4, P00514, Q17QP8
    UniProtKB/TrEMBL
    A0A3Q1MBY4
    Conserved Domains (2) summary
    cd12101
    Location:13 → 62
    DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:254 → 369
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00514.2 GenPept UniProtKB/Swiss-Prot:P00514

Gene LinkOut

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