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BMP2 bone morphogenetic protein 2 [ Bos taurus (domestic cattle) ]

Gene ID: 615037, updated on 5-Sep-2025
Official Symbol
BMP2provided by VGNC
Official Full Name
bone morphogenetic protein 2provided by VGNC
Primary source
VGNC:VGNC:26517
See related
BGD:BT11047; EnsemblRapid:ENSBTAG00070014790
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See BMP2 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (49152163..49163417)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene pyridoxal kinase-like Neighboring gene craniofacial development protein 2-like Neighboring gene uncharacterized LOC104973807 Neighboring gene uncharacterized LOC112449233

Genomic Sequence:
NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Influence of BMP-2 on early follicular development and mRNA expression of oocyte specific genes in bovine preantral follicles cultured in vitro. Rossi RO, et al. Histol Histopathol, 2016 Mar. PMID 26435174
  2. The expression and potential function of bone morphogenetic proteins 2 and 4 in bovine trophectoderm. Pennington KA, et al. Reprod Biol Endocrinol, 2012 Feb 13. PMID 22330732, Free PMC Article
  3. BMP2, 4 and 6 and BMPR1B are altered from early stages of bovine cystic ovarian disease development. Díaz PU, et al. Reproduction, 2016 Oct. PMID 27486268
  4. Expression of bone morphogenetic protein2 (BMP2), BMP4 and BMP receptors in the bovine ovary but absence of effects of BMP2 and BMP4 during IVM on bovine oocyte nuclear maturation and subsequent embryo development. Fatehi AN, et al. Theriogenology, 2005 Feb. PMID 15629804
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High BMP2 expression is associated with cystic ovarian disease.
    Title: BMP2, 4 and 6 and BMPR1B are altered from early stages of bovine cystic ovarian disease development.
  2. both FSH and BMP-2 reduced follicular mRNA expression of GDF9 and NLRP5 when compared to follicles cultured in media containing only FSH
    Title: Influence of BMP-2 on early follicular development and mRNA expression of oocyte specific genes in bovine preantral follicles cultured in vitro.
  3. The BMP2/4 ligand and receptor system presides within bovine trophectoderm prior to uterine attachment.
    Title: The expression and potential function of bone morphogenetic proteins 2 and 4 in bovine trophectoderm.
  4. concluded that a bone morphogenetic protein (BMP)-signaling system, consisting of BMP2, BMP4, type II and I receptors, is present in bovine antral follicles and plays a role in development and functioning of follicles rather than oocyte maturation
    Title: Expression of bone morphogenetic protein2 (BMP2), BMP4 and BMP receptors in the bovine ovary but absence of effects of BMP2 and BMP4 during IVM on bovine oocyte nuclear maturation and subsequent embryo development.
Submit: New GeneRIF Correction

Markers

Homology

Clone Names

  • MGC159940

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
bone morphogenetic protein 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099141.1 → NP_001092611.1  bone morphogenetic protein 2 precursor

    See identical proteins and their annotated locations for NP_001092611.1

    Status: PROVISIONAL

    Source sequence(s)
    BC142129
    UniProtKB/TrEMBL
    A0A3Q1NGR2, A5PJI9
    Related
    ENSBTAP00070019727.1, ENSBTAT00070033425.1
    Conserved Domains (2) summary
    cd19390
    Location:293 → 395
    TGF_beta_BMP2; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins
    pfam00688
    Location:36 → 266
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    49152163..49163417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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