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RPL19 ribosomal protein L19 [ Homo sapiens (human) ]

Gene ID: 6143, updated on 5-Jan-2020

Summary

Official Symbol
RPL19provided by HGNC
Official Full Name
ribosomal protein L19provided by HGNC
Primary source
HGNC:HGNC:10312
See related
Ensembl:ENSG00000108298 MIM:180466
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L19
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L19E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 933.9), lymph node (RPKM 615.1) and 25 other tissues See more
Orthologs

Genomic context

See RPL19 in Genome Data Viewer
Location:
17q12
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (39200283..39204732)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (37356536..37360980)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371768 Neighboring gene ADP ribosylation factor like GTPase 5C Neighboring gene calcium voltage-gated channel auxiliary subunit beta 1 Neighboring gene SH3 and cysteine rich domain 2 Neighboring gene transcription factor CP2-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L19 (RPL19), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L19 (RPL19), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L19 (RPL19), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L19 (RPL19), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ27452, MGC71997, DKFZp779D216

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
structural constituent of ribosome TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
cytoplasmic translation IDA
Inferred from Direct Assay
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translation TAS
Traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
cytosolic large ribosomal subunit TAS
Traceable Author Statement
more info
PubMed 
focal adhesion HDA PubMed 
membrane HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
polysomal ribosome IDA
Inferred from Direct Assay
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
60S ribosomal protein L19
Names
large ribosomal subunit protein eL19
NP_000972.1
NP_001317129.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053022.1 RefSeqGene

    Range
    5001..9450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1120

mRNA and Protein(s)

  1. NM_000981.4NP_000972.1  60S ribosomal protein L19 isoform 1

    See identical proteins and their annotated locations for NP_000972.1

    Status: REVIEWED

    Source sequence(s)
    BC095445, CF129418
    Consensus CDS
    CCDS42312.1
    UniProtKB/Swiss-Prot
    P84098
    Related
    ENSP00000225430.4, ENST00000225430.9
    Conserved Domains (2) summary
    cd01417
    Location:4167
    Ribosomal_L19e_E; Ribosomal protein L19e, eukaryotic. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an ...
    pfam07946
    Location:144192
    DUF1682; Protein of unknown function (DUF1682)
  2. NM_001330200.1NP_001317129.1  60S ribosomal protein L19 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AV743818, BF025822, EC496970, HY152200
    Consensus CDS
    CCDS82113.1
    UniProtKB/TrEMBL
    J3KTE4
    Related
    ENSP00000464538.1, ENST00000579260.5
    Conserved Domains (2) summary
    cd01417
    Location:2165
    Ribosomal_L19e_E; Ribosomal protein L19e, eukaryotic. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an ...
    pfam07946
    Location:142190
    DUF1682; Protein of unknown function (DUF1682)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    39200283..39204732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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