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RPL15 ribosomal protein L15 [ Homo sapiens (human) ]

Gene ID: 6138, updated on 4-Oct-2020

Summary

Official Symbol
RPL15provided by HGNC
Official Full Name
ribosomal protein L15provided by HGNC
Primary source
HGNC:HGNC:10306
See related
Ensembl:ENSG00000174748 MIM:604174
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L15; EC45; DBA12; RPL10; RPLY10; RPYL10
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L15E family of ribosomal proteins and a component of the 60S subunit. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Elevated expression of this gene has been observed in esophageal tumors and gastric cancer tissues, and deletion of this gene has been observed in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]
Expression
Ubiquitous expression in ovary (RPKM 335.5), thyroid (RPKM 183.2) and 25 other tissues See more
Orthologs

Genomic context

See RPL15 in Genome Data Viewer
Location:
3p24.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (23916545..23924631)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (23958295..23965187)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene UBE2E1 antisense RNA 1 Neighboring gene ubiquitin conjugating enzyme E2 E1 Neighboring gene ADP ribosylation factor like GTPase 4A pseudogene 4 Neighboring gene NFKB inhibitor interacting Ras like 1 Neighboring gene nuclear receptor subfamily 1 group D member 2 Neighboring gene nucleophosmin 1 pseudogene 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Diamond-Blackfan anemia 12
MedGen: C3809888 OMIM: 615550 GeneReviews: Diamond-Blackfan Anemia
Compare labs
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
GeneReviews: Not available

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2014-07-16)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated (2014-07-16)

ClinGen Genome Curation PagePubMed

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26304, MGC88603

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ribosome TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
60S ribosomal protein L15
Names
large ribosomal subunit protein eL15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033850.2 RefSeqGene

    Range
    5588..9445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1152

mRNA and Protein(s)

  1. NM_001253379.2NP_001240308.1  60S ribosomal protein L15 isoform 1

    See identical proteins and their annotated locations for NP_001240308.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
    Source sequence(s)
    AC124914, AI886077, BI544251, DA037869
    Consensus CDS
    CCDS2640.1
    UniProtKB/Swiss-Prot
    P61313
    UniProtKB/TrEMBL
    A0A024R2Q4
    Related
    ENSP00000483260.1, ENST00000611050.4
    Conserved Domains (1) summary
    pfam00827
    Location:2191
    Ribosomal_L15e; Ribosomal L15
  2. NM_001253380.2NP_001240309.1  60S ribosomal protein L15 isoform 1

    See identical proteins and their annotated locations for NP_001240309.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
    Source sequence(s)
    AC124914, AI886077, AY347528, DB461802
    Consensus CDS
    CCDS2640.1
    UniProtKB/Swiss-Prot
    P61313
    UniProtKB/TrEMBL
    A0A024R2Q4
    Related
    ENSP00000346867.5, ENST00000354811.5
    Conserved Domains (1) summary
    pfam00827
    Location:2191
    Ribosomal_L15e; Ribosomal L15
  3. NM_001253382.2NP_001240311.1  60S ribosomal protein L15 isoform 1

    See identical proteins and their annotated locations for NP_001240311.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
    Source sequence(s)
    AC124914, AI886077, BE893727, BU178524
    Consensus CDS
    CCDS2640.1
    UniProtKB/Swiss-Prot
    P61313
    UniProtKB/TrEMBL
    A0A024R2Q4
    Related
    ENSP00000493759.1, ENST00000644185.1
    Conserved Domains (1) summary
    pfam00827
    Location:2191
    Ribosomal_L15e; Ribosomal L15
  4. NM_001253383.3NP_001240312.1  60S ribosomal protein L15 isoform 1

    See identical proteins and their annotated locations for NP_001240312.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
    Source sequence(s)
    AC124914, DA205054, DC351786
    Consensus CDS
    CCDS2640.1
    UniProtKB/Swiss-Prot
    P61313
    UniProtKB/TrEMBL
    A0A024R2Q4
    Related
    ENSP00000416692.1, ENST00000413699.7
    Conserved Domains (1) summary
    pfam00827
    Location:2191
    Ribosomal_L15e; Ribosomal L15
  5. NM_001253384.2NP_001240313.1  60S ribosomal protein L15 isoform 2

    See identical proteins and their annotated locations for NP_001240313.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) includes an alternate exon in the 3' UTR and coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC124914, BC081565, BI544251
    Consensus CDS
    CCDS58818.1
    UniProtKB/Swiss-Prot
    P61313
    Related
    ENSP00000398788.2, ENST00000456530.7
    Conserved Domains (1) summary
    cl02977
    Location:2120
    Ribosomal_L15e; Ribosomal L15
  6. NM_002948.5NP_002939.2  60S ribosomal protein L15 isoform 1

    See identical proteins and their annotated locations for NP_002939.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-5 encode the same isoform (1).
    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS2640.1
    UniProtKB/Swiss-Prot
    P61313
    UniProtKB/TrEMBL
    A0A024R2Q4
    Related
    ENSP00000309334.4, ENST00000307839.9
    Conserved Domains (1) summary
    pfam00827
    Location:2191
    Ribosomal_L15e; Ribosomal L15

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    23916545..23924631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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