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RPL12 ribosomal protein L12 [ Homo sapiens (human) ]

Gene ID: 6136, updated on 9-Feb-2020

Summary

Official Symbol
RPL12provided by HGNC
Official Full Name
ribosomal protein L12provided by HGNC
Primary source
HGNC:HGNC:10302
See related
Ensembl:ENSG00000197958 MIM:180475
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L12
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. The protein binds directly to the 26S rRNA. This gene is co-transcribed with the U65 snoRNA, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 922.0), bone marrow (RPKM 591.7) and 25 other tissues See more
Orthologs

Genomic context

See RPL12 in Genome Data Viewer
Location:
9q33.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (127447674..127451406, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130209953..130213711, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268056 Neighboring gene solute carrier family 2 member 8 Neighboring gene zinc finger protein 79 Neighboring gene small nucleolar RNA, H/ACA box 65 Neighboring gene leucine rich repeat and sterile alpha motif containing 1 Neighboring gene niban apoptosis regulator 2 Neighboring gene uncharacterized LOC105376281

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ribosomal protein L12 (RPL12) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
large ribosomal subunit rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density EXP
Inferred from Experiment
more info
PubMed 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
60S ribosomal protein L12
Names
large ribosomal subunit protein uL11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000976.4NP_000967.1  60S ribosomal protein L12

    See identical proteins and their annotated locations for NP_000967.1

    Status: REVIEWED

    Source sequence(s)
    BC050644, BC105603, CB155565
    Consensus CDS
    CCDS6872.1
    UniProtKB/Swiss-Prot
    P30050
    Related
    ENSP00000354739.5, ENST00000361436.10
    Conserved Domains (1) summary
    PLN03072
    Location:1165
    PLN03072; 60S ribosomal protein L12; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    127447674..127451406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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