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FLNB filamin B [ Bos taurus (domestic cattle) ]

Gene ID: 613533, updated on 30-Jan-2025
Official Symbol
FLNBprovided by VGNC
Official Full Name
filamin Bprovided by VGNC
Primary source
VGNC:VGNC:29034
See related
BGD:BT15173; EnsemblRapid:ENSBTAG00070035499
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See FLNB in Genome Data Viewer
Location:
chromosome: 22
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (43132187..43272007, complement)

Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene protein ATP6V1FNB Neighboring gene deoxyribonuclease 1 like 3 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene microRNA mir-2370 Neighboring gene sarcolemma associated protein Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene DENN domain containing 6A

Genomic Sequence:
NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
filamin-B
Names
filamin B, beta (actin binding protein 278)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191460.3 → NP_001178389.1  filamin-B

    See identical proteins and their annotated locations for NP_001178389.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000022
    UniProtKB/TrEMBL
    A0AAA9TGQ2, E1BKX7
    Related
    ENSBTAP00070048417.1, ENSBTAT00070079957.1
    Conserved Domains (4) summary
    smart00557
    Location:1328 → 1417
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:17 → 121
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00630
    Location:1643 → 1732
    Filamin; Filamin/ABP280 repeat
    cl23780
    Location:1749 → 1803
    PepSY_TM; PepSY-associated TM region

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    43132187..43272007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005222908.5 → XP_005222965.1  filamin-B isoform X5

    See identical proteins and their annotated locations for XP_005222965.1

    UniProtKB/TrEMBL
    A0A3Q1M0Y7, A0AAA9TGQ2
    Related
    ENSBTAP00070048426.1, ENSBTAT00070079972.1
    Conserved Domains (3) summary
    smart00557
    Location:1421 → 1514
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:17 → 121
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00630
    Location:1418 → 1508
    Filamin; Filamin/ABP280 repeat

  2. XM_005222907.5 → XP_005222964.1  filamin-B isoform X4

    See identical proteins and their annotated locations for XP_005222964.1

    UniProtKB/TrEMBL
    A0AAA9TGQ2
    Conserved Domains (3) summary
    smart00557
    Location:1421 → 1514
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:17 → 121
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00630
    Location:1418 → 1508
    Filamin; Filamin/ABP280 repeat

  3. XM_005222906.5 → XP_005222963.1  filamin-B isoform X3

    See identical proteins and their annotated locations for XP_005222963.1

    UniProtKB/TrEMBL
    A0A3Q1MQ34, A0AAA9TGQ2
    Related
    ENSBTAP00070048408.1, ENSBTAT00070079940.1
    Conserved Domains (4) summary
    smart00557
    Location:1421 → 1514
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:17 → 121
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00630
    Location:1418 → 1508
    Filamin; Filamin/ABP280 repeat
    cl23780
    Location:1718 → 1772
    PepSY_TM; PepSY-associated TM region

  4. XM_005222905.5 → XP_005222962.1  filamin-B isoform X2

    UniProtKB/TrEMBL
    A0AAA9TGQ2
    Related
    ENSBTAP00070048380.1, ENSBTAT00070079884.1
    Conserved Domains (3) summary
    smart00557
    Location:1328 → 1417
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:17 → 121
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00630
    Location:1643 → 1732
    Filamin; Filamin/ABP280 repeat

  5. XM_005222904.5 → XP_005222961.1  filamin-B isoform X1

    UniProtKB/TrEMBL
    A0AAA9TGQ2
    Conserved Domains (3) summary
    smart00557
    Location:1328 → 1417
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:17 → 121
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00630
    Location:1643 → 1732
    Filamin; Filamin/ABP280 repeat

  6. XM_059879824.1 → XP_059735807.1  filamin-B isoform X6

    UniProtKB/TrEMBL
    A0AAA9TGQ2
Nucleotide Protein Strain
Heading Accession and Version

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