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RPL11 ribosomal protein L11 [ Homo sapiens (human) ]

Gene ID: 6135, updated on 11-Jun-2021

Summary

Official Symbol
RPL11provided by HGNC
Official Full Name
ribosomal protein L11provided by HGNC
Primary source
HGNC:HGNC:10301
See related
Ensembl:ENSG00000142676 MIM:604175
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L11; uL5; DBA7; GIG34
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in ovary (RPKM 1447.2), bone marrow (RPKM 910.3) and 25 other tissues See more
Orthologs
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Genomic context

See RPL11 in Genome Data Viewer
Location:
1p36.11
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (23691779..23696835)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24018269..24023325)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene myelodysplastic syndrome 2 translocation associated Neighboring gene elongation factor 1-alpha-like Neighboring gene elongin A Neighboring gene ELOA antisense RNA 1 Neighboring gene PITH domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with RPL11 as demonstrated by proximity dependent biotinylation proteomics PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of ribosomal protein L11 (RPL11) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 5S rRNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of ribosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
enables ubiquitin ligase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
involved_in cytoplasmic translation IC
Inferred by Curator
more info
PubMed 
involved_in cytoplasmic translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein neddylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein targeting IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA processing TAS
Traceable Author Statement
more info
 
involved_in regulation of signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in translational initiation TAS
Traceable Author Statement
more info
 
involved_in viral transcription TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
60S ribosomal protein L11
Names
CLL-associated antigen KW-12
cell growth-inhibiting protein 34
large ribosomal subunit protein uL5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011741.2 RefSeqGene

    Range
    5028..10057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1140

mRNA and Protein(s)

  1. NM_000975.5NP_000966.2  60S ribosomal protein L11 isoform 1

    See identical proteins and their annotated locations for NP_000966.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA748897, AL451000, BU954396, BX118515, CA335141
    Consensus CDS
    CCDS238.1
    UniProtKB/Swiss-Prot
    P62913
    UniProtKB/TrEMBL
    Q5VVD0
    Related
    ENSP00000496250.1, ENST00000643754.2
    Conserved Domains (1) summary
    PTZ00156
    Location:5175
    PTZ00156; 60S ribosomal protein L11; Provisional
  2. NM_001199802.1NP_001186731.1  60S ribosomal protein L11 isoform 2

    See identical proteins and their annotated locations for NP_001186731.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks 3 nts at an alternate splice site, as compared to variant 1. The resulting isoform (2) lacks an internal aa in the N-terminal region, as compared to isoform 1.
    Source sequence(s)
    BC018970, BF240826, BU954396, CA335141
    Consensus CDS
    CCDS85940.1
    UniProtKB/Swiss-Prot
    P62913
    Related
    ENSP00000363676.4, ENST00000374550.8
    Conserved Domains (1) summary
    PTZ00156
    Location:4174
    PTZ00156; 60S ribosomal protein L11; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    23691779..23696835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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