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RPL10 ribosomal protein L10 [ Homo sapiens (human) ]

Gene ID: 6134, updated on 5-Jul-2020

Summary

Official Symbol
RPL10provided by HGNC
Official Full Name
ribosomal protein L10provided by HGNC
Primary source
HGNC:HGNC:10298
See related
Ensembl:ENSG00000147403 MIM:312173
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
QM; L10; NOV; AUTSX5; DXS648; MRXS35; DXS648E
Summary
This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Expression
Ubiquitous expression in ovary (RPKM 795.4), lymph node (RPKM 396.3) and 25 other tissues See more
Orthologs

Genomic context

See RPL10 in Genome Data Viewer
Location:
Xq28
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (154398065..154402339)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153626571..153630901)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Xq28 distal FLNA-EMD recombination region Neighboring gene emerin Neighboring gene small nucleolar RNA, H/ACA box 70 Neighboring gene deoxyribonuclease 1 like 1 Neighboring gene tafazzin Neighboring gene uncharacterized protein BC009467

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Autism spectrum disorder
MedGen: C1510586 GeneReviews: Not available
Compare labs
Autism, susceptibility to, X-linked 5
MedGen: C3275438 OMIM: 300847 GeneReviews: Not available
Compare labs
MENTAL RETARDATION, X-LINKED, SYNDROMIC, 35
MedGen: C4478383 OMIM: 300998 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2018-10-24)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2018-10-24)

ClinGen Genome Curation Page

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L10 (RPL10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L10 (RPL10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L10 (RPL10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L10 (RPL10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human 60S ribosomal protein L10 (RPL10) at amino acid residues 53-54 and 56-57 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23544, FLJ27072, DKFZp686J1851

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
structural constituent of ribosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
translation regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
embryonic brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
liver regeneration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation IC
Inferred by Curator
more info
PubMed 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with smooth endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
60S ribosomal protein L10
Names
Wilms tumor-related protein
laminin receptor homolog
large ribosomal subunit protein uL16
tumor suppressor QM
NP_001243506.2
NP_001243509.2
NP_001290553.1
NP_001290554.1
NP_001290555.1
NP_006004.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012890.2 RefSeqGene

    Range
    4837..9111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256577.2NP_001243506.2  60S ribosomal protein L10 isoform b

    See identical proteins and their annotated locations for NP_001243506.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) has a distinct, longer C-terminus than isoform a.
    Source sequence(s)
    AC245140, AK307511, BC003358, DA589764
    UniProtKB/Swiss-Prot
    P27635
    Related
    ENSP00000395025.1, ENST00000458500.5
    Conserved Domains (1) summary
    cl00353
    Location:1110
    Ribosomal_L16_L10e; Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with ...
  2. NM_001256580.2NP_001243509.2  60S ribosomal protein L10 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC245140, BC003358, BC071918, BM845289, DA589764
    Consensus CDS
    CCDS76059.1
    UniProtKB/Swiss-Prot
    P27635
    UniProtKB/TrEMBL
    A0A087WV22
    Related
    ENSP00000479103.1, ENST00000618723.4
    Conserved Domains (1) summary
    cl00353
    Location:1173
    Ribosomal_L16_L10e; Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with ...
  3. NM_001303624.2NP_001290553.1  60S ribosomal protein L10 isoform a

    See identical proteins and their annotated locations for NP_001290553.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4, and 5 encode the same isoform (a).
    Source sequence(s)
    AC245140, AK026568, BC003358
    Consensus CDS
    CCDS14746.1
    UniProtKB/Swiss-Prot
    P27635
    UniProtKB/TrEMBL
    X5D2T3
    Related
    ENSP00000341730.4, ENST00000344746.8
    Conserved Domains (1) summary
    PTZ00173
    Location:1209
    PTZ00173; 60S ribosomal protein L10; Provisional
  4. NM_001303625.1NP_001290554.1  60S ribosomal protein L10 isoform a

    See identical proteins and their annotated locations for NP_001290554.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4, and 5 encode the same isoform (a).
    Source sequence(s)
    AC245140, BC003358, BM761549, DA589764
    Consensus CDS
    CCDS14746.1
    UniProtKB/Swiss-Prot
    P27635
    UniProtKB/TrEMBL
    X5D2T3
    Related
    ENSP00000388600.1, ENST00000436473.5
    Conserved Domains (1) summary
    PTZ00173
    Location:1209
    PTZ00173; 60S ribosomal protein L10; Provisional
  5. NM_001303626.1NP_001290555.1  60S ribosomal protein L10 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has a shorter 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (d) has a distinct, shorter C-terminus than isoform a.
    Source sequence(s)
    AC245140, BC003358, BC095425, CA776692
    UniProtKB/Swiss-Prot
    P27635
    Conserved Domains (1) summary
    cl00353
    Location:1110
    Ribosomal_L16_L10e; Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with ...
  6. NM_006013.5NP_006004.3  60S ribosomal protein L10 isoform a

    See identical proteins and their annotated locations for NP_006004.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1, 4, and 5 encode the same isoform (a).
    Source sequence(s)
    AC245140, AK130582
    Consensus CDS
    CCDS14746.1
    UniProtKB/Swiss-Prot
    P27635
    UniProtKB/TrEMBL
    X5D2T3
    Related
    ENSP00000413436.2, ENST00000424325.6
    Conserved Domains (1) summary
    PTZ00173
    Location:1209
    PTZ00173; 60S ribosomal protein L10; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    154398065..154402339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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