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DEFB136 defensin beta 136 [ Homo sapiens (human) ]

Gene ID: 613210, updated on 5-Mar-2024

Summary

Official Symbol
DEFB136provided by HGNC
Official Full Name
defensin beta 136provided by HGNC
Primary source
HGNC:HGNC:34433
See related
Ensembl:ENSG00000205884 AllianceGenome:HGNC:34433
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DEFB137
Summary
Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 8p23. [provided by RefSeq, Nov 2014]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See DEFB136 in Genome Data Viewer
Location:
8p23.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (11973937..11974599, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (7765666..7766328)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (11831446..11832108, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene tRNA-Glu (CTC) 11-1 Neighboring gene uncharacterized LOC105379244 Neighboring gene Sharpr-MPRA regulatory region 12781 Neighboring gene uncharacterized LOC112268017 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:11814647-11815164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:11815165-11815680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:11843909-11844409 Neighboring gene defensin beta 135 Neighboring gene nuclear receptor binding SET domain protein 3 pseudogene Neighboring gene defensin beta 134 Neighboring gene olfactory receptor family 7 subfamily E member 160 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
defensin beta 136
Names
beta-defensin 136
beta-defensin 137

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033018.2NP_001028190.2  defensin beta 136 precursor

    See identical proteins and their annotated locations for NP_001028190.2

    Status: REVIEWED

    Source sequence(s)
    DQ012026
    Consensus CDS
    CCDS43709.1
    UniProtKB/Swiss-Prot
    Q30KP8, Q4QY36
    Related
    ENSP00000371644.2, ENST00000382209.2
    Conserved Domains (1) summary
    pfam17333
    Location:2575
    DEFB136; Beta-defensin 136

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    11973937..11974599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p14 PATCHES

    Range
    1373422..1374084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    7765666..7766328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)