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RPL3L ribosomal protein L3 like [ Homo sapiens (human) ]

Gene ID: 6123, updated on 5-Jul-2025
Official Symbol
RPL3Lprovided by HGNC
Official Full Name
ribosomal protein L3 likeprovided by HGNC
Primary source
HGNC:HGNC:10351
See related
Ensembl:ENSG00000140986 MIM:617416; AllianceGenome:HGNC:10351
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CMD2D
Summary
This gene encodes a protein that shares sequence similarity with ribosomal protein L3. The protein belongs to the L3P family of ribosomal proteins. Unlike the ubiquitous expression of ribosomal protein genes, this gene has a tissue-specific pattern of expression, with the highest levels of expression in skeletal muscle and heart. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. [provided by RefSeq, Jul 2008]
Expression
Biased expression in heart (RPKM 32.1), prostate (RPKM 5.1) and 2 other tissues See more
Orthologs
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See RPL3L in Genome Data Viewer
Location:
16p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1943974..1954689, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (1963946..1975094, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1993975..2004690, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1961835-1962392 Neighboring gene heparan sulfate-glucosamine 3-sulfotransferase 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1968509-1969070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1969071-1969634 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1969635-1970196 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1970197-1970760 Neighboring gene Sharpr-MPRA regulatory region 1858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1991100-1991989 Neighboring gene uncharacterized LOC124903625 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7010 Neighboring gene methionine sulfoxide reductase B1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2003405-2004394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2007755-2008596 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7011 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10241 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10242 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2012172-2013117 Neighboring gene NADH:ubiquinone oxidoreductase subunit B10 Neighboring gene small nucleolar RNA, H/ACA box 10 Neighboring gene ribosomal protein S2

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding TAS
Traceable Author Statement
more info
PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
enables structural constituent of ribosome TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of myotube differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of striated muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
involved_in translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in translation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of cytosolic large ribosomal subunit HDA PubMed 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cytosolic large ribosomal subunit IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
 
located_in ribosome TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
ribosomal protein uL3-like
Names
60S ribosomal protein L3-like
large ribosomal subunit protein uL3-like

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005061.3NP_005052.1  ribosomal protein uL3-like

    See identical proteins and their annotated locations for NP_005052.1

    Status: REVIEWED

    Source sequence(s)
    AC005363
    Consensus CDS
    CCDS10450.1
    UniProtKB/Swiss-Prot
    Q92901
    UniProtKB/TrEMBL
    B2R7Y3
    Related
    ENSP00000268661.7, ENST00000268661.8
    Conserved Domains (1) summary
    PTZ00103
    Location:1398
    PTZ00103; 60S ribosomal protein L3; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    1943974..1954689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522571.3XP_011520873.1  ribosomal protein uL3-like isoform X1

    UniProtKB/TrEMBL
    B2R7Y3
    Conserved Domains (2) summary
    PTZ00103
    Location:6403
    PTZ00103; 60S ribosomal protein L3; Provisional
    cl00324
    Location:12378
    RplC; Ribosomal protein L3 [Translation, ribosomal structure and biogenesis]

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791799.1 Reference GRCh38.p14 PATCHES

    Range
    10122..21271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333186.1XP_054189161.1  ribosomal protein uL3-like isoform X1

    UniProtKB/TrEMBL
    B2R7Y3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    1963946..1975094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313574.1XP_054169549.1  ribosomal protein uL3-like isoform X1

    UniProtKB/TrEMBL
    B2R7Y3