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RPL3L ribosomal protein L3 like [ Homo sapiens (human) ]

Gene ID: 6123, updated on 21-Dec-2019

Summary

Official Symbol
RPL3Lprovided by HGNC
Official Full Name
ribosomal protein L3 likeprovided by HGNC
Primary source
HGNC:HGNC:10351
See related
Ensembl:ENSG00000140986 MIM:617416
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein that shares sequence similarity with ribosomal protein L3. The protein belongs to the L3P family of ribosomal proteins. Unlike the ubiquitous expression of ribosomal protein genes, this gene has a tissue-specific pattern of expression, with the highest levels of expression in skeletal muscle and heart. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. [provided by RefSeq, Jul 2008]
Expression
Biased expression in heart (RPKM 32.1), prostate (RPKM 5.1) and 2 other tissues See more
Orthologs

Genomic context

See RPL3L in Genome Data Viewer
Location:
16p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (1943974..1955123, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1994580..2004679, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene heparan sulfate-glucosamine 3-sulfotransferase 6 Neighboring gene methionine sulfoxide reductase B1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B10 Neighboring gene small nucleolar RNA, H/ACA box 10 Neighboring gene ribosomal protein S2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding TAS
Traceable Author Statement
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
ribosome TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
60S ribosomal protein L3-like
Names
large ribosomal subunit protein uL3-like

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005061.3NP_005052.1  60S ribosomal protein L3-like

    See identical proteins and their annotated locations for NP_005052.1

    Status: REVIEWED

    Source sequence(s)
    AC005363
    Consensus CDS
    CCDS10450.1
    UniProtKB/Swiss-Prot
    Q92901
    Related
    ENSP00000268661.7, ENST00000268661.8
    Conserved Domains (2) summary
    PTZ00103
    Location:1398
    PTZ00103; 60S ribosomal protein L3; Provisional
    cl00324
    Location:7373
    RplC; Ribosomal protein L3 [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    1943974..1955123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522571.2XP_011520873.1  60S ribosomal protein L3-like isoform X1

    Conserved Domains (2) summary
    PTZ00103
    Location:6403
    PTZ00103; 60S ribosomal protein L3; Provisional
    cl00324
    Location:12378
    RplC; Ribosomal protein L3 [Translation, ribosomal structure and biogenesis]
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