U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SLC6A5 solute carrier family 6 member 5 [ Canis lupus familiaris (dog) ]

Gene ID: 612095, updated on 1-Mar-2025
Official Symbol
SLC6A5provided by VGNC
Official Full Name
solute carrier family 6 member 5provided by VGNC
Primary source
VGNC:VGNC:46466
See related
Ensembl:ENSCAFG00845021856 RGD:12158665
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See SLC6A5 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
15
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 21 NC_051825.1 (43704400..43760475)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 21 NC_006603.4 (42059192..42115260)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 21 NC_049242.1 (43263792..43319870)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 21 NC_049281.1 (42705998..42761954)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 21 NC_049762.1 (42882046..42937792)

Chromosome 21 - NC_051825.1Genomic Context describing neighboring genes Neighboring gene protein arginine methyltransferase 3 Neighboring gene uncharacterized LOC119865032 Neighboring gene inorganic pyrophosphatase-like Neighboring gene neural EGFL like 1 Neighboring gene isocitrate dehydrogenase 3 (NAD+) gamma pseudogene

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A glycine transporter SLC6A5 frameshift mutation causes startle disease in Spanish greyhounds. Murphy SC, et al. Hum Genet, 2019 May. PMID 30847549
  2. Startle disease in Irish wolfhounds associated with a microdeletion in the glycine transporter GlyT2 gene. Gill JL, et al. Neurobiol Dis, 2011 Jul. PMID 21420493, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables glycine:sodium symporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycine import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in synaptic transmission, glycinergic IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
sodium- and chloride-dependent glycine transporter 2
Names
solute carrier family 6 (neurotransmitter transporter, glycine), member 5

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051825.1 Reference ROS_Cfam_1.0

    Range
    43704400..43760475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038429613.1 → XP_038285541.1  sodium- and chloride-dependent glycine transporter 2

    UniProtKB/TrEMBL
    A0A8C0NN56, A0A8I3PME4
    Related
    ENSCAFP00845030245.1, ENSCAFT00845038632.1
    Conserved Domains (1) summary
    cd11499
    Location:152 → 748
    SLC6sbd_GlyT2; Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049281.1 Alternate UMICH_Zoey_3.1

    Range
    42705998..42761954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038506189.1 → XP_038362117.1  sodium- and chloride-dependent glycine transporter 2

    Conserved Domains (1) summary
    cd11499
    Location:152 → 748
    SLC6sbd_GlyT2; Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049762.1 Alternate UNSW_CanFamBas_1.0

    Range
    42882046..42937792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038632293.1 → XP_038488221.1  sodium- and chloride-dependent glycine transporter 2

    Conserved Domains (1) summary
    cd11499
    Location:152 → 748
    SLC6sbd_GlyT2; Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049242.1 Alternate UU_Cfam_GSD_1.0

    Range
    43263792..43319870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038568193.1 → XP_038424121.1  sodium- and chloride-dependent glycine transporter 2

    UniProtKB/TrEMBL
    A0A8C0NN56, A0A8I3PME4
    Conserved Domains (1) summary
    cd11499
    Location:152 → 748
    SLC6sbd_GlyT2; Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    42059192..42115260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022407940.2 → XP_022263648.2  sodium- and chloride-dependent glycine transporter 2

    UniProtKB/TrEMBL
    A0A8C0NN56, A0A8I3PME4
    Conserved Domains (1) summary
    cd11499
    Location:152 → 748
    SLC6sbd_GlyT2; Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials