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CTSZ cathepsin Z [ Canis lupus familiaris (dog) ]

Gene ID: 611983, updated on 27-Jun-2026
Official Symbol
CTSZprovided by VGNC
Official Full Name
cathepsin Zprovided by VGNC
Primary source
VGNC:VGNC:39717
See related
Ensembl:ENSCAFG00845014050 RGD:12368038
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Try the new Transcripts and proteins table
See CTSZ in Genome Data Viewer
Location:
chromosome: 24
Exon count:
6
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 24 NC_051828.1 (44609433..44616884, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 24 NC_006606.4 (42989417..42996868, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 24 NC_049245.1 (44491470..44498960, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 24 NC_049284.1 (43712987..43720434, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 24 NC_049765.1 (43831671..43839127, complement)

Chromosome 24 - NC_051828.1Genomic Context describing neighboring genes Neighboring gene phosphorylated adapter RNA export protein-like Neighboring gene negative elongation factor complex member C/D Neighboring gene tubulin beta 1 class VI Neighboring gene ATP synthase F1 subunit epsilon

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
cathepsin Z
XP_038290163.1
XP_038313658.1
XP_038365321.1
XP_038428665.1
XP_038492944.1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051828.1 Reference ROS_Cfam_1.0

    Range
    44609433..44616884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038434235.1 → XP_038290163.1  cathepsin Z

    UniProtKB/TrEMBL
    A0A8C0L900, A0A8C0LCY7, A0A8I3S0K4
    Related
    ENSCAFP00845019771.1, ENSCAFT00845025140.1
    Conserved Domains (1) summary
    cd02698
    Location:60 → 300
    Peptidase_C1A_CathepsinX; Cathepsin X; the only papain-like lysosomal cysteine peptidase exhibiting carboxymonopeptidase activity. It can also act as a carboxydipeptidase, like cathepsin B, but has been shown to preferentially cleave substrates through a monopeptidyl ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049284.1 Alternate UMICH_Zoey_3.1

    Range
    43712987..43720434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038509393.1 → XP_038365321.1  

    Conserved Domains (1) summary
    cd02698
    Location:60 → 300
    Peptidase_C1A_CathepsinX; Cathepsin X; the only papain-like lysosomal cysteine peptidase exhibiting carboxymonopeptidase activity. It can also act as a carboxydipeptidase, like cathepsin B, but has been shown to preferentially cleave substrates through a monopeptidyl ...

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049765.1 Alternate UNSW_CanFamBas_1.0

    Range
    43831671..43839127 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038637016.1 → XP_038492944.1  

    Conserved Domains (1) summary
    cd02698
    Location:60 → 300
    Peptidase_C1A_CathepsinX; Cathepsin X; the only papain-like lysosomal cysteine peptidase exhibiting carboxymonopeptidase activity. It can also act as a carboxydipeptidase, like cathepsin B, but has been shown to preferentially cleave substrates through a monopeptidyl ...

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049245.1 Alternate UU_Cfam_GSD_1.0

    Range
    44491470..44498960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038572737.1 → XP_038428665.1  cathepsin Z

    UniProtKB/TrEMBL
    A0A8C0L900, A0A8C0LCY7, A0A8I3S0K4
    Conserved Domains (1) summary
    cd02698
    Location:60 → 300
    Peptidase_C1A_CathepsinX; Cathepsin X; the only papain-like lysosomal cysteine peptidase exhibiting carboxymonopeptidase activity. It can also act as a carboxydipeptidase, like cathepsin B, but has been shown to preferentially cleave substrates through a monopeptidyl ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006606.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    42989417..42996868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038457730.1 → XP_038313658.1  cathepsin Z

    UniProtKB/TrEMBL
    A0A8C0L900, A0A8C0LCY7, A0A8I3S0K4
    Conserved Domains (1) summary
    cd02698
    Location:60 → 300
    Peptidase_C1A_CathepsinX; Cathepsin X; the only papain-like lysosomal cysteine peptidase exhibiting carboxymonopeptidase activity. It can also act as a carboxydipeptidase, like cathepsin B, but has been shown to preferentially cleave substrates through a monopeptidyl ...
Nucleotide Protein
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