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OAS2 2'-5'-oligoadenylate synthetase 2 [ Canis lupus familiaris (dog) ]

Gene ID: 611051, updated on 25-Jul-2026
Official Symbol
OAS2provided by VGNC
Official Full Name
2'-5'-oligoadenylate synthetase 2provided by VGNC
Primary source
VGNC:VGNC:44087
See related
Ensembl:ENSCAFG00845022313 RGD:12401231
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Try the new Transcripts and proteins table
See OAS2 in Genome Data Viewer
Location:
chromosome: 26
Exon count:
11
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 26 NC_051830.1 (10671578..10689735)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 26 NC_006608.4 (10549630..10565518)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 26 NC_049247.1 (10756857..10772738)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 26 NC_049286.1 (10645194..10661076)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 26 NC_049767.1 (10708391..10724287)

Chromosome 26 - NC_051830.1Genomic Context describing neighboring genes Neighboring gene 2'-5'-oligoadenylate synthetase 1 Neighboring gene 2'-5'-oligoadenylate synthetase 3 Neighboring gene uncharacterized LOC119866156 Neighboring gene uncharacterized LOC111092704 Neighboring gene deltex E3 ubiquitin ligase 1 Neighboring gene RAS protein activator like 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla. Perelygin AA, et al. J Mol Evol, 2006 Oct. PMID 17024523
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 2'-5'-oligoadenylate synthetase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of viral genome replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of ribonuclease activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
2'-5'-oligoadenylate synthase 2
NP_001041599.1

Length

  • 685
XP_038292038.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048134.1 → NP_001041599.1  2'-5'-oligoadenylate synthase 2

    See identical proteins and their annotated locations for NP_001041599.1

    Status: PROVISIONAL

    Source sequence(s)
    AY906957
    UniProtKB/TrEMBL
    A0A8C0KYM0, Q2KM16
    Conserved Domains (2) summary
    cd05400
    Location:31 → 157
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:494 → 681
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051830.1 Reference ROS_Cfam_1.0

    Range
    10671578..10689735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038436110.1 → XP_038292038.1  2'-5'-oligoadenylate synthase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KYM0, A0A8I3PQU7
    Related
    ENSCAFP00845030857.1, ENSCAFT00845039381.1
    Conserved Domains (2) summary
    cd05400
    Location:31 → 157
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:495 → 682
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049286.1 Alternate UMICH_Zoey_3.1

    Range
    10645194..10661076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049767.1 Alternate UNSW_CanFamBas_1.0

    Range
    10708391..10724287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049247.1 Alternate UU_Cfam_GSD_1.0

    Range
    10756857..10772738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006608.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    10549630..10565518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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