U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CGAS cyclic GMP-AMP synthase [ Canis lupus familiaris (dog) ]

Gene ID: 611033, updated on 25-Jul-2026
Official Symbol
CGASprovided by VGNC
Official Full Name
cyclic GMP-AMP synthaseprovided by VGNC
Primary source
VGNC:VGNC:43047
See related
Ensembl:ENSCAFG00845012039 RGD:12413456
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
MB21D1
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See CGAS in Genome Data Viewer
Location:
chromosome: 12
Exon count:
7
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (36066175..36085892, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (35380775..35399989, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (35751269..35770689, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (35605589..35625008, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (35627370..35646829, complement)

Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 43 Neighboring gene sororin-like Neighboring gene mitochondrial tRNA translation optimization 1 Neighboring gene translation initiation factor IF-2-like Neighboring gene eukaryotic translation elongation factor 1 alpha 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 2',3'-cyclic GMP-AMP synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in activation of innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to exogenous dsRNA IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in paracrine signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of defense response to virus by host IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of type I interferon production IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in site of double-strand break IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
cyclic GMP-AMP synthase
Names
Mab-21 domain containing 1
XP_022281959.1
XP_022281960.1
XP_038348166.1
XP_038348167.1
XP_038348168.1
XP_038348169.1
XP_038348170.1
XP_038348171.1
XP_038348172.1
XP_038410452.1
XP_038410453.1
XP_038410454.1
XP_038410455.1
XP_038410456.1
XP_038410457.1
XP_038410458.1
XP_038474842.1
XP_038530528.1
XP_038530529.1
XP_038530530.1
XP_038530531.1
XP_038530550.1
XP_038539886.1
XP_038539887.1
XP_038539888.1
XP_038539889.1
XP_038539890.1
XP_038539891.1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051816.1 Reference ROS_Cfam_1.0

    Range
    36066175..36085892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038683960.1 → XP_038539888.1  cyclic GMP-AMP synthase isoform X2

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 361
    Mab-21; Mab-21 protein

  2. XM_038683958.1 → XP_038539886.1  cyclic GMP-AMP synthase isoform X6

    UniProtKB/TrEMBL
    A0A8I3NL22
    Related
    ENSCAFP00845016817.1, ENSCAFT00845021394.1
    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 417
    Mab-21; Mab-21 protein

  3. XM_038683959.1 → XP_038539887.1  cyclic GMP-AMP synthase isoform X1

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 388
    Mab-21; Mab-21 protein

  4. XM_038683963.1 → XP_038539891.1  cyclic GMP-AMP synthase isoform X5

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 361
    Mab-21; Mab-21 protein

  5. XM_038683962.1 → XP_038539890.1  cyclic GMP-AMP synthase isoform X4

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 361
    Mab-21; Mab-21 protein

  6. XM_038683961.1 → XP_038539889.1  cyclic GMP-AMP synthase isoform X3

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 361
    Mab-21; Mab-21 protein

RNA

  1. XR_005435688.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049272.1 Alternate UMICH_Zoey_3.1

    Range
    35605589..35625008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038492241.1 → XP_038348169.1  

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 361
    Mab-21; Mab-21 protein

  2. XM_038492239.1 → XP_038348167.1  

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 428
    Mab-21; Mab-21 protein

  3. XM_038492238.1 → XP_038348166.1  

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 501
    Mab-21; Mab-21 protein

  4. XM_038492240.1 → XP_038348168.1  

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 388
    Mab-21; Mab-21 protein

  5. XM_038492244.1 → XP_038348172.1  

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 361
    Mab-21; Mab-21 protein

  6. XM_038492243.1 → XP_038348171.1  

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 361
    Mab-21; Mab-21 protein

  7. XM_038492242.1 → XP_038348170.1  

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 361
    Mab-21; Mab-21 protein

RNA

  1. XR_005334179.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

    Range
    35627370..35646829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038618914.1 → XP_038474842.1  

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

    Range
    35751269..35770689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038554527.1 → XP_038410455.1  cyclic GMP-AMP synthase isoform X2

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 361
    Mab-21; Mab-21 protein

  2. XM_038554525.1 → XP_038410453.1  cyclic GMP-AMP synthase isoform X11

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 428
    Mab-21; Mab-21 protein

  3. XM_038554524.1 → XP_038410452.1  cyclic GMP-AMP synthase isoform X10

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 501
    Mab-21; Mab-21 protein

  4. XM_038554526.1 → XP_038410454.1  cyclic GMP-AMP synthase isoform X1

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 388
    Mab-21; Mab-21 protein

  5. XM_038554530.1 → XP_038410458.1  cyclic GMP-AMP synthase isoform X5

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 361
    Mab-21; Mab-21 protein

  6. XM_038554529.1 → XP_038410457.1  cyclic GMP-AMP synthase isoform X4

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 361
    Mab-21; Mab-21 protein

  7. XM_038554528.1 → XP_038410456.1  cyclic GMP-AMP synthase isoform X3

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 361
    Mab-21; Mab-21 protein

RNA

  1. XR_005367919.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    35380775..35399989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022426251.2 → XP_022281959.1  cyclic GMP-AMP synthase isoform X2

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 361
    Mab-21; Mab-21 protein

  2. XM_038674601.1 → XP_038530529.1  cyclic GMP-AMP synthase isoform X13

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 428
    Mab-21; Mab-21 protein

  3. XM_038674600.1 → XP_038530528.1  cyclic GMP-AMP synthase isoform X12

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 501
    Mab-21; Mab-21 protein

  4. XM_038674602.1 → XP_038530530.1  cyclic GMP-AMP synthase isoform X1

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 388
    Mab-21; Mab-21 protein

  5. XM_038674622.1 → XP_038530550.1  cyclic GMP-AMP synthase isoform X5

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 361
    Mab-21; Mab-21 protein

  6. XM_022426252.2 → XP_022281960.1  cyclic GMP-AMP synthase isoform X4

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 361
    Mab-21; Mab-21 protein

  7. XM_038674603.1 → XP_038530531.1  cyclic GMP-AMP synthase isoform X3

    Conserved Domains (2) summary
    PRK07003
    Location:8 → 150
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03281
    Location:203 → 361
    Mab-21; Mab-21 protein

RNA

  1. XR_002632004.2 RNA Sequence

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials