NHERF4 NHERF family PDZ scaffold protein 4 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: NHERF4provided by VGNC
Official Full Name: NHERF family PDZ scaffold protein 4provided by VGNC
Primary source: VGNC:VGNC:44400
See related: Ensembl:ENSCAFG00845000320 RGD:12365583
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: PDZD3
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	5	NC_051809.1 (14630596..14635834, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	5	NC_006587.4 (14740337..14745572, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	5	NC_049226.1 (14713092..14718336, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	5	NC_049265.1 (14768680..14773917, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	5	NC_049746.1 (14672879..14678123, complement)

Chromosome 5 - NC_051809.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein-membrane adaptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: Na(+)/H(+) exchange regulatory cofactor NHE-RF4

Names: PDZ domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051809.1 Reference ROS_Cfam_1.0

Range

14630596..14635834 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038664668.1 → XP_038520596.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X2

UniProtKB/TrEMBL

A0A8I3MV35

Related

ENSCAFP00845000365.1, ENSCAFT00845000530.1

Conserved Domains (2) summary

smart00228
Location:409 → 478

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:47 → 127

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038664669.1 → XP_038520597.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X3

UniProtKB/TrEMBL

A0A8I3RQR6

Conserved Domains (1) summary

cd00992
Location:48 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038664667.1 → XP_038520595.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X1

UniProtKB/TrEMBL

A0A8I3MV35

Conserved Domains (2) summary

smart00228
Location:410 → 479

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:48 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038664670.1 → XP_038520598.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X4

Conserved Domains (1) summary

cd00992
Location:48 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049265.1 Alternate UMICH_Zoey_3.1

Range

14768680..14773917 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038474787.1 → XP_038330715.1

Conserved Domains (2) summary

smart00228
Location:409 → 478

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:47 → 127

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038474788.1 → XP_038330716.1

Conserved Domains (1) summary

cd00992
Location:48 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038474786.1 → XP_038330714.1

Conserved Domains (2) summary

smart00228
Location:410 → 479

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:48 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038474790.1 → XP_038330718.1

Conserved Domains (1) summary

cd00992
Location:48 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049746.1 Alternate UNSW_CanFamBas_1.0

Range

14672879..14678123 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038600130.1 → XP_038456058.1

Conserved Domains (2) summary

smart00228
Location:409 → 478

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:47 → 127

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038600131.1 → XP_038456059.1

Conserved Domains (1) summary

cd00992
Location:48 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038600129.1 → XP_038456057.1

Conserved Domains (2) summary

smart00228
Location:410 → 479

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:48 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038600132.1 → XP_038456060.1

Conserved Domains (1) summary

cd00992
Location:48 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049226.1 Alternate UU_Cfam_GSD_1.0

Range

14713092..14718336 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038535935.1 → XP_038391863.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X2

UniProtKB/TrEMBL

A0A8I3MV35

Conserved Domains (2) summary

smart00228
Location:409 → 478

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:47 → 127

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038535936.1 → XP_038391864.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X3

UniProtKB/TrEMBL

A0A8I3RQR6

Conserved Domains (1) summary

cd00992
Location:48 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038535934.1 → XP_038391862.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X1

UniProtKB/TrEMBL

A0A8I3MV35

Conserved Domains (2) summary

smart00228
Location:410 → 479

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:48 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038535937.1 → XP_038391865.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X4

Conserved Domains (1) summary

cd00992
Location:48 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

14740337..14745572 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_848119.5 → XP_853212.2 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X2

UniProtKB/TrEMBL

A0A8I3MV35

Conserved Domains (2) summary

smart00228
Location:409 → 478

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:47 → 127

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038508372.1 → XP_038364300.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X3

UniProtKB/TrEMBL

A0A8I3RQR6

Conserved Domains (1) summary

cd00992
Location:48 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_005619678.3 → XP_005619735.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X1

UniProtKB/TrEMBL

A0A8I3MV35

Conserved Domains (2) summary

smart00228
Location:410 → 479

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:48 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_022418210.2 → XP_022273918.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X4

Conserved Domains (1) summary

cd00992
Location:48 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...