U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HCN2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 [ Homo sapiens (human) ]

Gene ID: 610, updated on 6-Jul-2025
Official Symbol
HCN2provided by HGNC
Official Full Name
hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2provided by HGNC
Primary source
HGNC:HGNC:4846
See related
Ensembl:ENSG00000099822 MIM:602781; AllianceGenome:HGNC:4846
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FEB2; BCNG2; EIG17; HAC-1; BCNG-2; GEFSP11
Summary
The protein encoded by this gene is a hyperpolarization-activated cation channel involved in the generation of native pacemaker activity in the heart and in the brain. The encoded protein is activated by cAMP and can produce a fast, large current. Defects in this gene were noted as a possible cause of some forms of epilepsy. [provided by RefSeq, Jan 2017]
Expression
Biased expression in brain (RPKM 15.0), heart (RPKM 4.6) and 2 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See HCN2 in Genome Data Viewer
Location:
19p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (589881..617159)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (543772..571465)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (589881..617159)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:543421-544066 Neighboring gene granzyme M Neighboring gene CRISPRi-validated cis-regulatory element chr19.73 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:570844-571416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13564 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9606 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9607 Neighboring gene BSG antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:583377-583939 Neighboring gene basigin (Ok blood group) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:583940-584501 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9608 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:588071-588650 Neighboring gene Rho GTPase activating protein 33 pseudogene Neighboring gene MPRA-validated peak3211 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13565 Neighboring gene uncharacterized LOC107987266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13566 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:613339-613520 Neighboring gene RNA polymerase mitochondrial Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:629803-630486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9611 Neighboring gene uncharacterized LOC105372234 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13567 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:638495-639220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9613 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:644145-645085 Neighboring gene fibroblast growth factor 22

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 
enables cAMP binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables intracellularly cAMP-activated cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables sodium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables voltage-gated sodium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in ammonium transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ammonium transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to aldosterone IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cAMP IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cGMP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in membrane depolarization during cardiac muscle cell action potential IC
Inferred by Curator
more info
PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of membrane depolarization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to hormone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sodium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sodium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of HCN channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of HCN channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of HCN channel complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon IEA
Inferred from Electronic Annotation
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite membrane IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in somatodendritic compartment IEA
Inferred from Electronic Annotation
more info
 
part_of voltage-gated potassium channel complex TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Names
brain cyclic nucleotide-gated channel 2
hyperpolarization activated cyclic nucleotide gated potassium channel 2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052810.1 RefSeqGene

    Range
    4989..32267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001194.4NP_001185.3  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

    See identical proteins and their annotated locations for NP_001185.3

    Status: REVIEWED

    Source sequence(s)
    AC005559, AF065164, AJ012582, BC039619
    Consensus CDS
    CCDS12035.1
    UniProtKB/Swiss-Prot
    O60742, O60743, O75267, Q9UBS2, Q9UL51
    Related
    ENSP00000251287.1, ENST00000251287.3
    Conserved Domains (4) summary
    COG0664
    Location:538673
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:544652
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:229474
    Ion_trans; Ion transport protein
    pfam08412
    Location:167209
    Ion_trans_N; Ion transport protein N-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    589881..617159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    543772..571465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)