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HCN2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 [ Homo sapiens (human) ]

Gene ID: 610, updated on 27-Nov-2022

Summary

Official Symbol
HCN2provided by HGNC
Official Full Name
hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2provided by HGNC
Primary source
HGNC:HGNC:4846
See related
Ensembl:ENSG00000099822 MIM:602781; AllianceGenome:HGNC:4846
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FEB2; BCNG2; EIG17; HAC-1; BCNG-2; GEFSP11
Summary
The protein encoded by this gene is a hyperpolarization-activated cation channel involved in the generation of native pacemaker activity in the heart and in the brain. The encoded protein is activated by cAMP and can produce a fast, large current. Defects in this gene were noted as a possible cause of some forms of epilepsy. [provided by RefSeq, Jan 2017]
Expression
Biased expression in brain (RPKM 15.0), heart (RPKM 4.6) and 2 other tissues See more
Orthologs
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Genomic context

See HCN2 in Genome Data Viewer
Location:
19p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (589881..617159)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (543772..571465)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (589881..617159)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr19.73 Neighboring gene BSG antisense RNA 1 Neighboring gene basigin (Ok blood group) Neighboring gene Rho GTPase activating protein 33 pseudogene Neighboring gene uncharacterized LOC107987266 Neighboring gene RNA polymerase mitochondrial Neighboring gene uncharacterized LOC105372234 Neighboring gene fibroblast growth factor 22

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cAMP binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables intracellular cAMP-activated cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables voltage-gated potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables voltage-gated sodium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cGMP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in membrane depolarization during cardiac muscle cell action potential IC
Inferred by Curator
more info
PubMed 
involved_in potassium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of SA node cell action potential IC
Inferred by Curator
more info
PubMed 
involved_in regulation of cation channel activity IC
Inferred by Curator
more info
PubMed 
involved_in regulation of heart rate by cardiac conduction IC
Inferred by Curator
more info
PubMed 
involved_in regulation of membrane depolarization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of membrane depolarization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sodium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of HCN channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of HCN channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of HCN channel complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of voltage-gated potassium channel complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Names
brain cyclic nucleotide-gated channel 2
hyperpolarization activated cyclic nucleotide gated potassium channel 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052810.1 RefSeqGene

    Range
    4989..32267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001194.4NP_001185.3  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

    See identical proteins and their annotated locations for NP_001185.3

    Status: REVIEWED

    Source sequence(s)
    AC005559, AF065164, AJ012582, BC039619
    Consensus CDS
    CCDS12035.1
    UniProtKB/Swiss-Prot
    Q9UBS2, Q9UL51
    Related
    ENSP00000251287.1, ENST00000251287.3
    Conserved Domains (4) summary
    COG0664
    Location:538673
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:544652
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:229474
    Ion_trans; Ion transport protein
    pfam08412
    Location:167209
    Ion_trans_N; Ion transport protein N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    589881..617159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    543772..571465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)