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GCLC glutamate-cysteine ligase catalytic subunit [ Canis lupus familiaris (dog) ]

Gene ID: 609822, updated on 17-Aug-2024

Summary

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Official Symbol
GCLCprovided by VGNC
Official Full Name
glutamate-cysteine ligase catalytic subunitprovided by VGNC
Primary source
VGNC:VGNC:41147
See related
Ensembl:ENSCAFG00845010300
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See GCLC in Genome Data Viewer
Location:
chromosome: 12
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (21495557..21544499, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (20898243..20947109, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (21243198..21292135, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (20996643..21045520, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (21104936..21153860, complement)

Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA44 Neighboring gene uncharacterized LOC119874272 Neighboring gene uncharacterized LOC111098290 Neighboring gene uncharacterized LOC106559580 Neighboring gene kelch like family member 31

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables glutamate-cysteine ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of glutamate-cysteine ligase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
glutamate--cysteine ligase catalytic subunit
XP_038347987.1
XP_038410254.1
XP_038474116.1
XP_038539704.1
XP_852845.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051816.1 Reference ROS_Cfam_1.0

    Range
    21495557..21544499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038683776.1 → XP_038539704.1  glutamate--cysteine ligase catalytic subunit

    UniProtKB/TrEMBL
    A0A8C0QHV3, A0A8I3NES9, A0A8P0N5C9
    Related
    ENSCAFP00845014183.1, ENSCAFT00845018193.1
    Conserved Domains (2) summary
    PRK00087
    Location:22 → 67
    PRK00087; bifunctional 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/30S ribosomal protein S1
    pfam03074
    Location:236 → 608
    GCS; Glutamate-cysteine ligase

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049272.1 Alternate UMICH_Zoey_3.1

    Range
    20996643..21045520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038492059.1 → XP_038347987.1  glutamate--cysteine ligase catalytic subunit

    Conserved Domains (2) summary
    PRK00087
    Location:22 → 67
    PRK00087; bifunctional 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/30S ribosomal protein S1
    pfam03074
    Location:236 → 608
    GCS; Glutamate-cysteine ligase

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

    Range
    21104936..21153860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038618188.1 → XP_038474116.1  glutamate--cysteine ligase catalytic subunit

    Conserved Domains (2) summary
    PRK00087
    Location:22 → 67
    PRK00087; bifunctional 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/30S ribosomal protein S1
    pfam03074
    Location:236 → 608
    GCS; Glutamate-cysteine ligase

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

    Range
    21243198..21292135 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038554326.1 → XP_038410254.1  glutamate--cysteine ligase catalytic subunit

    UniProtKB/TrEMBL
    A0A8C0QHV3, A0A8I3NES9, A0A8P0N5C9
    Conserved Domains (2) summary
    PRK00087
    Location:22 → 67
    PRK00087; bifunctional 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/30S ribosomal protein S1
    pfam03074
    Location:236 → 608
    GCS; Glutamate-cysteine ligase

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    20898243..20947109 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_847752.6 → XP_852845.1  glutamate--cysteine ligase catalytic subunit

    UniProtKB/TrEMBL
    A0A8C0QHV3, A0A8I3NES9, A0A8P0N5C9
    Conserved Domains (2) summary
    PRK00087
    Location:22 → 67
    PRK00087; bifunctional 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/30S ribosomal protein S1
    pfam03074
    Location:236 → 608
    GCS; Glutamate-cysteine ligase
Nucleotide Protein
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