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ROS1 ROS proto-oncogene 1, receptor tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 6098, updated on 8-Dec-2018

Summary

Official Symbol
ROS1provided by HGNC
Official Full Name
ROS proto-oncogene 1, receptor tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:10261
See related
Ensembl:ENSG00000047936 MIM:165020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ROS; MCF3; c-ros-1
Summary
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward lung (RPKM 10.3) See more
Orthologs

Genomic context

See ROS1 in Genome Data Viewer
Location:
6q22.1
Exon count:
46
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (117287918..117426065, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (117609530..117747018, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377964 Neighboring gene vestigial like family member 2 Neighboring gene RNA, 7SK small nuclear pseudogene 18 Neighboring gene RNA, 7SK small nuclear pseudogene 51 Neighboring gene RAP1B, member of RAS oncogene family pseudogene 3 Neighboring gene RNA, U6 small nuclear 253, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval.
NHGRI GWA Catalog
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of ROS in umbilical cord blood mononuclear cells and T-cell lines PubMed
Tat tat HIV-1 Tat induces endoplasmic reticulum (ER) stress response proteins CASP12 (Caspase 12), DDIT3 (CHOP), ROS1, ERN-1 (p-IRE1), EIF2AK3 (p-PERK), and ATF6 in human brain microvascular endothelial cells (HBMECs) PubMed
tat Treatment of astrocytes with cell-permeable superoxide dismutase (SOD) leads to a decrease in Tat-induced ROS generation and NF-kappaB activation PubMed
Vpr vpr Administration of recombinant Vpr to human neurons results in a slow but sustained elevation of intracellular calcium, which leads to ROS production and impairs glutamate signaling PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • NAD metabolism, sirtuins and aging, organism-specific biosystem (from WikiPathways)
    NAD metabolism, sirtuins and aging, organism-specific biosystemA model for DNA damage, inflammation, NAD+, and aging. Two key events, the activation of PARP by DNA damage and the decreased NAMPT expression associated with inflammation, lead to decreased SIRT1 an...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
columnar/cuboidal epithelial cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of TOR signaling IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
regulation of phosphate transport IEA
Inferred from Electronic Annotation
more info
 
signal transduction by protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
proto-oncogene tyrosine-protein kinase ROS
Names
ROS proto-oncogene 1 , receptor tyrosine kinase
c-ros oncogene 1 , receptor tyrosine kinase
proto-oncogene c-Ros-1
transmembrane tyrosine-specific protein kinase
v-ros avian UR2 sarcoma virus oncogene homolog 1
NP_002935.2
XP_006715611.1
XP_011534351.1
XP_011534352.1
XP_011534353.1
XP_011534354.1
XP_011534355.1
XP_011534356.1
XP_011534357.1
XP_011534358.1
XP_011534359.1
XP_011534360.1
XP_016866661.1
XP_016866662.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033929.1 RefSeqGene

    Range
    5001..142489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_997

mRNA and Protein(s)

  1. NM_002944.2NP_002935.2  proto-oncogene tyrosine-protein kinase ROS precursor

    See identical proteins and their annotated locations for NP_002935.2

    Status: REVIEWED

    Source sequence(s)
    M34353
    Consensus CDS
    CCDS5116.1
    UniProtKB/Swiss-Prot
    P08922
    Related
    ENSP00000357494.3, ENST00000368508.7
    Conserved Domains (3) summary
    cd00063
    Location:202281
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05044
    Location:19502216
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
    pfam07714
    Location:19452215
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    117287918..117426065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011173.1XP_016866662.1  proto-oncogene tyrosine-protein kinase ROS isoform X7

  2. XM_017011172.1XP_016866661.1  proto-oncogene tyrosine-protein kinase ROS isoform X6

  3. XM_011536051.2XP_011534353.1  proto-oncogene tyrosine-protein kinase ROS isoform X3

    Conserved Domains (3) summary
    cd00063
    Location:202281
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05044
    Location:19512217
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
    pfam07714
    Location:19462216
    Pkinase_Tyr; Protein tyrosine kinase
  4. XM_011536053.2XP_011534355.1  proto-oncogene tyrosine-protein kinase ROS isoform X8

    Conserved Domains (3) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05044
    Location:19022168
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
    pfam07714
    Location:18972167
    Pkinase_Tyr; Protein tyrosine kinase
  5. XM_006715548.4XP_006715611.1  proto-oncogene tyrosine-protein kinase ROS isoform X5

    Related
    ENSP00000357493.3, ENST00000368507.7
    Conserved Domains (3) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05044
    Location:19452211
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
    pfam07714
    Location:19402210
    Pkinase_Tyr; Protein tyrosine kinase
  6. XM_011536052.2XP_011534354.1  proto-oncogene tyrosine-protein kinase ROS isoform X4

    Conserved Domains (3) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05044
    Location:19462212
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
    pfam07714
    Location:19412211
    Pkinase_Tyr; Protein tyrosine kinase
  7. XM_011536050.2XP_011534352.1  proto-oncogene tyrosine-protein kinase ROS isoform X2

    Conserved Domains (3) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05044
    Location:19592225
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
    pfam07714
    Location:19542224
    Pkinase_Tyr; Protein tyrosine kinase
  8. XM_011536049.2XP_011534351.1  proto-oncogene tyrosine-protein kinase ROS isoform X1

    Conserved Domains (3) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05044
    Location:19602226
    PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
    pfam07714
    Location:19552225
    Pkinase_Tyr; Protein tyrosine kinase
  9. XM_011536054.2XP_011534356.1  proto-oncogene tyrosine-protein kinase ROS isoform X9

    Conserved Domains (3) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:19552200
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:19602200
    PKc_like; Protein Kinases, catalytic domain
  10. XM_011536055.2XP_011534357.1  proto-oncogene tyrosine-protein kinase ROS isoform X10

    Conserved Domains (1) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  11. XM_011536056.2XP_011534358.1  proto-oncogene tyrosine-protein kinase ROS isoform X11

    Conserved Domains (1) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  12. XM_011536057.3XP_011534359.1  proto-oncogene tyrosine-protein kinase ROS isoform X12

    Conserved Domains (1) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  13. XM_011536058.2XP_011534360.1  proto-oncogene tyrosine-protein kinase ROS isoform X13

    Conserved Domains (1) summary
    cd00063
    Location:211290
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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