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HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 [ Canis lupus familiaris (dog) ]

Gene ID: 609237, updated on 5-Mar-2024

Summary

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Official Symbol
HERC6provided by VGNC
Official Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6provided by VGNC
Primary source
VGNC:VGNC:41662
See related
Ensembl:ENSCAFG00845016852
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 32
Exon count:
23
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 32 NC_051836.1 (11748514..11804925)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 32 NC_006614.4 (30203843..30259601, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 32 NC_049253.1 (28204467..28260972, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 32 NC_049292.1 (11831645..11886841)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 32 NC_049773.1 (11656819..11712063)

Chromosome 32 - NC_051836.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119867182 Neighboring gene ATP synthase F(0) complex subunit C2, mitochondrial-like Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase 5 Neighboring gene PIGY upstream open reading frame Neighboring gene phosphatidylinositol glycan anchor biosynthesis class Y

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase HERC6
Names
hect domain and RLD 6
XP_005639224.1
XP_005639225.1
XP_038300029.1
XP_038300030.1
XP_038374435.1
XP_038438089.1
XP_038438090.1
XP_038502360.1
XP_038502361.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051836.1 Reference ROS_Cfam_1.0

    Range
    11748514..11804925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038444101.1 → XP_038300029.1  probable E3 ubiquitin-protein ligase HERC6 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PTL1, A0A8I3NXY0
    Related
    ENSCAFP00845023469.1, ENSCAFT00845029885.1
    Conserved Domains (2) summary
    COG5184
    Location:25 → 282
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:661 → 1003
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  2. XM_038444102.1 → XP_038300030.1  probable E3 ubiquitin-protein ligase HERC6 isoform X2

    UniProtKB/TrEMBL
    A0A8C0PTL1
    Related
    ENSCAFP00845023452.1, ENSCAFT00845029859.1
    Conserved Domains (2) summary
    COG5184
    Location:25 → 282
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:660 → 1002
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049292.1 Alternate UMICH_Zoey_3.1

    Range
    11831645..11886841
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038518507.1 → XP_038374435.1  probable E3 ubiquitin-protein ligase HERC6 isoform X3

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049773.1 Alternate UNSW_CanFamBas_1.0

    Range
    11656819..11712063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038646432.1 → XP_038502360.1  probable E3 ubiquitin-protein ligase HERC6 isoform X4

  2. XM_038646433.1 → XP_038502361.1  probable E3 ubiquitin-protein ligase HERC6 isoform X5

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049253.1 Alternate UU_Cfam_GSD_1.0

    Range
    28204467..28260972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038582162.1 → XP_038438090.1  probable E3 ubiquitin-protein ligase HERC6 isoform X2

    UniProtKB/TrEMBL
    A0A8C0PTL1

  2. XM_038582161.1 → XP_038438089.1  probable E3 ubiquitin-protein ligase HERC6 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PTL1

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006614.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    30203843..30259601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005639168.4 → XP_005639225.1  probable E3 ubiquitin-protein ligase HERC6 isoform X7

    UniProtKB/TrEMBL
    A0A8C0PTL1
    Conserved Domains (4) summary
    smart00119
    Location:684 → 1002
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:660 → 1002
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:93 → 143
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:238 → 267
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

  2. XM_005639167.4 → XP_005639224.1  probable E3 ubiquitin-protein ligase HERC6 isoform X6

    UniProtKB/TrEMBL
    A0A8C0PTL1, A0A8P0NBV1
    Conserved Domains (4) summary
    smart00119
    Location:685 → 1003
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:661 → 1003
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:93 → 143
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:238 → 267
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
Nucleotide Protein
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