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ROBO2 roundabout guidance receptor 2 [ Homo sapiens (human) ]

Gene ID: 6092, updated on 27-Dec-2018

Summary

Official Symbol
ROBO2provided by HGNC
Official Full Name
roundabout guidance receptor 2provided by HGNC
Primary source
HGNC:HGNC:10250
See related
Ensembl:ENSG00000185008 MIM:602431
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAX3
Summary
The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Expression
Broad expression in brain (RPKM 5.1), lung (RPKM 2.8) and 14 other tissues See more
Orthologs

Genomic context

See ROBO2 in Genome Data Viewer
Location:
3p12.3
Exon count:
34
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (75906675..77649964)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (75955845..77699115)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 92, pseudogene Neighboring gene microRNA 4273 Neighboring gene zinc finger protein 717 Neighboring gene uncharacterized LOC107986020 Neighboring gene CAP1 pseudogene 1 Neighboring gene uncharacterized LOC102724949 Neighboring gene RNA, U6 small nuclear 386, pseudogene Neighboring gene voltage dependent anion channel 1 pseudogene 7 Neighboring gene uncharacterized LOC105377171 Neighboring gene RNA, U6 small nuclear 217, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Vesicoureteral reflux 2
MedGen: C1970483 OMIM: 610878 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
NHGRI GWA Catalog
Common variation near ROBO2 is associated with expressive vocabulary in infancy.
NHGRI GWA Catalog
Genetic variants associated with disordered eating.
NHGRI GWA Catalog
Genome-wide association study of chronic periodontitis in a general German population.
NHGRI GWA Catalog
Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women.
NHGRI GWA Catalog
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog

Pathways from BioSystems

  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Regulation of Commissural axon pathfinding by Slit and Robo, organism-specific biosystem (from REACTOME)
    Regulation of Commissural axon pathfinding by Slit and Robo, organism-specific biosystemCommissural axons project to the floor plate, attracted by the interaction of their DCC receptors with netrin1 produced by floor plate cells. The axons are insensitive to the repulsive action of slit...
  • Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
    Signaling by Robo receptor, organism-specific biosystemThe Roundabout (Robo) family encodes transmembrane receptors that regulate axonal guidance and cell migration. The major function of the Robo receptors is to mediate repulsion of the navigating growt...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1568

Gene Ontology Provided by GOA

Function Evidence Code Pubs
axon guidance receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
axon guidance receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Roundabout signaling pathway IEA
Inferred from Electronic Annotation
more info
 
aorta development ISS
Inferred from Sequence or Structural Similarity
more info
 
aortic valve morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic process involved in luteolysis IEP
Inferred from Expression Pattern
more info
PubMed 
axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
axon midline choice point recognition ISS
Inferred from Sequence or Structural Similarity
more info
 
brain development IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
central nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
endocardial cushion formation ISS
Inferred from Sequence or Structural Similarity
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
metanephros development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of negative chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
olfactory bulb interneuron development ISS
Inferred from Sequence or Structural Similarity
more info
 
outflow tract septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Notch signaling pathway involved in heart induction ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
pulmonary valve morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
retinal ganglion cell axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
spinal cord development IEA
Inferred from Electronic Annotation
more info
 
ureteric bud development IMP
Inferred from Mutant Phenotype
more info
PubMed 
ventricular septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
axolemma ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
roundabout homolog 2
Names
roundabout, axon guidance receptor, homolog 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027734.2 RefSeqGene

    Range
    4982..1748271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128929.3NP_001122401.1  roundabout homolog 2 isoform ROBO2a

    See identical proteins and their annotated locations for NP_001122401.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the use of an alternate promoter and has multiple differences compared to variant 4. These differences result in a distinct 5' UTR and the use of an alternate start codon compared to variant 4. The encoded protein (isoform ROBO2a; PMID 16829019) has a distinct N-terminus and is shorter than isoform 4.
    Source sequence(s)
    AC126467, AC133040, DQ533873
    Consensus CDS
    CCDS54609.1
    UniProtKB/Swiss-Prot
    Q9HCK4
    Related
    ENSP00000417335.2, ENST00000487694.7
    Conserved Domains (7) summary
    cd00096
    Location:451518
    Ig; Immunoglobulin domain
    cd05726
    Location:344433
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:46145
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:440521
    IG_like; Immunoglobulin like
    cd00063
    Location:538631
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:241326
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:153237
    Ig; Immunoglobulin domain
  2. NM_001290039.1NP_001276968.1  roundabout homolog 2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001276968.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region compared to variant 4. The encoded protein (isoform 3) is shorter than variant 4.
    Source sequence(s)
    AC117516, AC133040, BC144306, DQ533874
    UniProtKB/Swiss-Prot
    Q9HCK4
    Conserved Domains (7) summary
    cd00096
    Location:439506
    Ig; Immunoglobulin domain
    cd05726
    Location:332421
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:30129
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:428509
    IG_like; Immunoglobulin like
    cd00063
    Location:526619
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:225310
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:137221
    Ig; Immunoglobulin domain
  3. NM_001290040.1NP_001276969.1  roundabout homolog 2 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001276969.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
    Source sequence(s)
    AC133040, BC144303, DQ533874
    UniProtKB/Swiss-Prot
    Q9HCK4
    Related
    ENSP00000327536.8, ENST00000332191.12
    Conserved Domains (7) summary
    cd00096
    Location:439506
    Ig; Immunoglobulin domain
    cd05726
    Location:332421
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:30129
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:428509
    IG_like; Immunoglobulin like
    cd00063
    Location:526619
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:225310
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:137221
    Ig; Immunoglobulin domain
  4. NM_001290065.1NP_001276994.1  roundabout homolog 2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences compared to variant 4. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon compared to variant 4; the 5'-most initiation codon, as used in variant 4, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG resulting in an isoform (5) with a shorter N-terminus compared to isoform 4.
    Source sequence(s)
    AC133040, BC144302, DQ533874
    UniProtKB/Swiss-Prot
    Q9HCK4
    Conserved Domains (1) summary
    cd00063
    Location:147239
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  5. NM_002942.4NP_002933.1  roundabout homolog 2 isoform ROBO2b precursor

    See identical proteins and their annotated locations for NP_002933.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the coding region compared to variant 4. The encoded protein (isoform ROBO2b; PMID 16829019) is shorter than variant 4.
    Source sequence(s)
    AC133040, DQ533874
    Consensus CDS
    CCDS43109.1
    UniProtKB/Swiss-Prot
    Q9HCK4
    Related
    ENSP00000417164.1, ENST00000461745.5
    Conserved Domains (5) summary
    cd05726
    Location:328417
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:30129
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00409
    Location:424505
    IG; Immunoglobulin
    cd00063
    Location:522615
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:137221
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    75906675..77649964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006997.1XP_016862486.1  roundabout homolog 2 isoform X16

  2. XM_017007005.1XP_016862494.1  roundabout homolog 2 isoform X25

  3. XM_017006990.1XP_016862479.1  roundabout homolog 2 isoform X8

  4. XM_017006996.1XP_016862485.1  roundabout homolog 2 isoform X15

  5. XM_017006992.1XP_016862481.1  roundabout homolog 2 isoform X10

  6. XM_017007004.1XP_016862493.1  roundabout homolog 2 isoform X24

  7. XM_011533981.2XP_011532283.1  roundabout homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_011532283.1

    Conserved Domains (6) summary
    cd05726
    Location:355444
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00409
    Location:451532
    IG; Immunoglobulin
    cd00063
    Location:549642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam16599
    Location:13741431
    PTN13_u3; Unstructured linker region on PTN13 protein between PDZ
    cl11960
    Location:160244
    Ig; Immunoglobulin domain
  8. XM_017006988.1XP_016862477.1  roundabout homolog 2 isoform X6

  9. XM_017006994.1XP_016862483.1  roundabout homolog 2 isoform X13

  10. XM_017007001.1XP_016862490.1  roundabout homolog 2 isoform X21

  11. XM_017006995.1XP_016862484.1  roundabout homolog 2 isoform X14

  12. XM_011533983.1XP_011532285.1  roundabout homolog 2 isoform X5

    See identical proteins and their annotated locations for XP_011532285.1

    Conserved Domains (7) summary
    cd00096
    Location:462529
    Ig; Immunoglobulin domain
    cd05726
    Location:355444
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:451532
    IG_like; Immunoglobulin like
    cd00063
    Location:549642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:248333
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:160244
    Ig; Immunoglobulin domain
  13. XM_011533984.1XP_011532286.1  roundabout homolog 2 isoform X12

    See identical proteins and their annotated locations for XP_011532286.1

    Conserved Domains (7) summary
    cd00096
    Location:462529
    Ig; Immunoglobulin domain
    cd05726
    Location:355444
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:451532
    IG_like; Immunoglobulin like
    cd00063
    Location:549642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:248333
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:160244
    Ig; Immunoglobulin domain
  14. XM_011533982.1XP_011532284.1  roundabout homolog 2 isoform X3

    See identical proteins and their annotated locations for XP_011532284.1

    Conserved Domains (7) summary
    cd00096
    Location:462529
    Ig; Immunoglobulin domain
    cd05726
    Location:355444
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:451532
    IG_like; Immunoglobulin like
    cd00063
    Location:549642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:248333
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:160244
    Ig; Immunoglobulin domain
  15. XM_017006991.1XP_016862480.1  roundabout homolog 2 isoform X9

  16. XM_011533985.1XP_011532287.1  roundabout homolog 2 isoform X20

    See identical proteins and their annotated locations for XP_011532287.1

    Conserved Domains (7) summary
    cd00096
    Location:462529
    Ig; Immunoglobulin domain
    cd05726
    Location:355444
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:451532
    IG_like; Immunoglobulin like
    cd00063
    Location:549642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:248333
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:160244
    Ig; Immunoglobulin domain
  17. XM_017006987.1XP_016862476.1  roundabout homolog 2 isoform X4

  18. XM_017007002.1XP_016862491.1  roundabout homolog 2 isoform X22

  19. XM_017006989.1XP_016862478.1  roundabout homolog 2 isoform X7

    Conserved Domains (7) summary
    cd00096
    Location:458525
    Ig; Immunoglobulin domain
    cd05726
    Location:351440
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:447528
    IG_like; Immunoglobulin like
    cd00063
    Location:545638
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:248333
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:160244
    Ig; Immunoglobulin domain
  20. XM_017007003.1XP_016862492.1  roundabout homolog 2 isoform X23

    Conserved Domains (7) summary
    cd00096
    Location:458525
    Ig; Immunoglobulin domain
    cd05726
    Location:351440
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:53152
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:447528
    IG_like; Immunoglobulin like
    cd00063
    Location:545638
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:248333
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:160244
    Ig; Immunoglobulin domain
  21. XM_017006999.1XP_016862488.1  roundabout homolog 2 isoform X18

  22. XM_017006986.1XP_016862475.1  roundabout homolog 2 isoform X2

    Conserved Domains (7) summary
    cd00096
    Location:439506
    Ig; Immunoglobulin domain
    cd05726
    Location:332421
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    cd07693
    Location:30129
    Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
    smart00410
    Location:428509
    IG_like; Immunoglobulin like
    cd00063
    Location:526619
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:225310
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:137221
    Ig; Immunoglobulin domain
  23. XM_017006998.1XP_016862487.1  roundabout homolog 2 isoform X17

  24. XM_017007006.1XP_016862495.1  roundabout homolog 2 isoform X26

  25. XM_017007000.1XP_016862489.1  roundabout homolog 2 isoform X19

  26. XM_017006993.1XP_016862482.1  roundabout homolog 2 isoform X11

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