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HELB DNA helicase B [ Canis lupus familiaris (dog) ]

Gene ID: 608595, updated on 27-Jun-2026
Official Symbol
HELBprovided by VGNC
Official Full Name
DNA helicase Bprovided by VGNC
Primary source
VGNC:VGNC:41648
See related
Ensembl:ENSCAFG00845012872 RGD:12115864
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Try the new Transcripts and proteins table
See HELB in Genome Data Viewer
Location:
chromosome: 10
Exon count:
15
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (8877731..8909045)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (8696318..8727628)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (9120841..9152148)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (8754221..8785523)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (8999596..9030904)

Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097585 Neighboring gene interleukin 1 receptor associated kinase 3 Neighboring gene glutamate receptor interacting protein 1 Neighboring gene 60S ribosomal protein L9-like Neighboring gene 40S ribosomal protein S24-like

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

Homology

Preferred Names
DNA helicase B
XP_013972689.2
XP_022279876.1
XP_022279877.1
XP_022279878.1
XP_022279879.1
XP_022279880.1
XP_038343966.1
XP_038343967.1
XP_038343968.1
XP_038343969.1
XP_038343970.1
XP_038343971.1
XP_038343972.1
XP_038405860.1
XP_038405861.1
XP_038405862.1
XP_038405863.1
XP_038405864.1
XP_038405865.1
XP_038405867.1
XP_038469836.1
XP_038469837.1
XP_038469838.1
XP_038469839.1
XP_038469840.1
XP_038469841.1
XP_038469842.1
XP_038535190.1
XP_038535191.1
XP_038535192.1
XP_038535193.1
XP_038535194.1
XP_038535195.1
XP_038535196.1
XP_850757.4

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051814.1 Reference ROS_Cfam_1.0

    Range
    8877731..8909045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038679264.1 → XP_038535192.1  DNA helicase B isoform X7

    UniProtKB/TrEMBL
    A0A8I3NCM6
    Related
    ENSCAFP00845017950.1, ENSCAFT00845022897.1
    Conserved Domains (2) summary
    COG0507
    Location:492 → 1000
    RecD; ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I [Replication, recombination and repair]
    cd17933
    Location:503 → 700
    DEXSc_RecD-like; DEXS-box helicase domain of RecD and similar proteins

  2. XM_038679262.1 → XP_038535190.1  DNA helicase B isoform X1

    UniProtKB/TrEMBL
    A0A8I3NCM6
    Conserved Domains (2) summary
    COG0507
    Location:492 → 1000
    RecD; ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I [Replication, recombination and repair]
    cd17933
    Location:503 → 700
    DEXSc_RecD-like; DEXS-box helicase domain of RecD and similar proteins

  3. XM_038679263.1 → XP_038535191.1  DNA helicase B isoform X2

    UniProtKB/TrEMBL
    A0A8I3NCM6
    Conserved Domains (2) summary
    COG0507
    Location:492 → 980
    RecD; ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I [Replication, recombination and repair]
    cd17933
    Location:503 → 700
    DEXSc_RecD-like; DEXS-box helicase domain of RecD and similar proteins

  4. XM_038679265.1 → XP_038535193.1  DNA helicase B isoform X3

    UniProtKB/TrEMBL
    A0A8I3NCM6
    Conserved Domains (2) summary
    COG0507
    Location:494 → 882
    RecD; ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I [Replication, recombination and repair]
    cl28899
    Location:493 → 582
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  5. XM_038679266.1 → XP_038535194.1  DNA helicase B isoform X4

    Conserved Domains (2) summary
    COG0507
    Location:374 → 762
    RecD; ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I [Replication, recombination and repair]
    cl28899
    Location:373 → 462
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  6. XM_038679267.1 → XP_038535195.1  DNA helicase B isoform X5

    UniProtKB/TrEMBL
    A0A8C0L176
    Conserved Domains (2) summary
    COG0507
    Location:492 → 939
    RecD; ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I [Replication, recombination and repair]
    cd17933
    Location:503 → 700
    DEXSc_RecD-like; DEXS-box helicase domain of RecD and similar proteins

  7. XM_038679268.1 → XP_038535196.1  DNA helicase B isoform X6

    Conserved Domains (2) summary
    COG0507
    Location:186 → 694
    RecD; ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I [Replication, recombination and repair]
    cd17933
    Location:197 → 394
    DEXSc_RecD-like; DEXS-box helicase domain of RecD and similar proteins

RNA

  1. XR_005433132.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049270.1 Alternate UMICH_Zoey_3.1

    Range
    8754221..8785523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038488040.1 → XP_038343968.1  

  2. XM_038488038.1 → XP_038343966.1  

  3. XM_038488039.1 → XP_038343967.1  

  4. XM_038488041.1 → XP_038343969.1  

  5. XM_038488042.1 → XP_038343970.1  

  6. XM_038488043.1 → XP_038343971.1  

  7. XM_038488044.1 → XP_038343972.1  

RNA

  1. XR_005331647.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

    Range
    8999596..9030904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038613910.1 → XP_038469838.1  

  2. XM_038613908.1 → XP_038469836.1  

  3. XM_038613909.1 → XP_038469837.1  

  4. XM_038613911.1 → XP_038469839.1  

  5. XM_038613912.1 → XP_038469840.1  

  6. XM_038613913.1 → XP_038469841.1  

  7. XM_038613914.1 → XP_038469842.1  

RNA

  1. XR_005399780.1 RNA Sequence

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

    Range
    9120841..9152148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038549934.1 → XP_038405862.1  DNA helicase B isoform X10

    UniProtKB/TrEMBL
    A0A8I3NCM6

  2. XM_038549932.1 → XP_038405860.1  DNA helicase B isoform X1

    UniProtKB/TrEMBL
    A0A8I3NCM6

  3. XM_038549933.1 → XP_038405861.1  DNA helicase B isoform X2

    UniProtKB/TrEMBL
    A0A8I3NCM6

  4. XM_038549935.1 → XP_038405863.1  DNA helicase B isoform X3

    UniProtKB/TrEMBL
    A0A8I3NCM6

  5. XM_038549936.1 → XP_038405864.1  DNA helicase B isoform X4

  6. XM_038549937.1 → XP_038405865.1  DNA helicase B isoform X5

    UniProtKB/TrEMBL
    A0A8C0L176

  7. XM_038549939.1 → XP_038405867.1  DNA helicase B isoform X6

RNA

  1. XR_005365350.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    8696318..8727628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_845664.6 → XP_850757.4  DNA helicase B isoform X11

    UniProtKB/TrEMBL
    A0A8I3NCM6
    Conserved Domains (1) summary
    cl26262
    Location:360 → 993
    RecD; ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I [Replication, recombination and repair]

  2. XM_014117214.3 → XP_013972689.2  DNA helicase B isoform X1

    UniProtKB/TrEMBL
    A0A8I3NCM6
    Conserved Domains (1) summary
    cl26262
    Location:360 → 993
    RecD; ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I [Replication, recombination and repair]

  3. XM_022424168.2 → XP_022279876.1  DNA helicase B isoform X2

    UniProtKB/TrEMBL
    A0A8I3NCM6
    Conserved Domains (1) summary
    cl26262
    Location:360 → 973
    RecD; ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I [Replication, recombination and repair]

  4. XM_022424169.2 → XP_022279877.1  DNA helicase B isoform X3

    UniProtKB/TrEMBL
    A0A8I3NCM6
    Conserved Domains (1) summary
    cl26262
    Location:494 → 882
    RecD; ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I [Replication, recombination and repair]

  5. XM_022424170.2 → XP_022279878.1  DNA helicase B isoform X4

    Conserved Domains (1) summary
    cl26262
    Location:374 → 762
    RecD; ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I [Replication, recombination and repair]

  6. XM_022424171.2 → XP_022279879.1  DNA helicase B isoform X5

    UniProtKB/TrEMBL
    A0A8C0L176
    Conserved Domains (2) summary
    cl21455
    Location:500 → 701
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl26262
    Location:492 → 939
    RecD; ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I [Replication, recombination and repair]

  7. XM_022424172.2 → XP_022279880.1  DNA helicase B isoform X6

    Conserved Domains (1) summary
    cl26262
    Location:54 → 687
    RecD; ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I [Replication, recombination and repair]

RNA

  1. XR_001317025.3 RNA Sequence

Nucleotide Protein
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