ANGPT2 angiopoietin 2 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: ANGPT2provided by VGNC
Official Full Name: angiopoietin 2provided by VGNC
Primary source: VGNC:VGNC:37855
See related: Ensembl:ENSCAFG00845022531
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: ANG-2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	16	NC_051820.1 (57592625..57645271)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	16	NC_006598.4 (53935215..53987886, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	16	NC_049237.1 (55977188..56030293)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	16	NC_049276.1 (58549239..58616758, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	16	NC_049757.1 (55601814..55654409)

Chromosome 16 - NC_051820.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serum angiopoietin-2 levels in dogs with splenic haemangiosarcoma, haemangioma, and splenitis.
Title: Serum angiopoietin-2 levels in dogs with splenic haemangiosarcoma, haemangioma, and splenitis.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Tie signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: angiopoietin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048126.1 → NP_001041591.1 angiopoietin-2 precursor

See identical proteins and their annotated locations for NP_001041591.1

Status: PROVISIONAL

Source sequence(s)

AB256019

UniProtKB/Swiss-Prot

A0A8J8

UniProtKB/TrEMBL

A0A8C0QPL8, A0A8C0R006, A0A8I3S5R4

Related

ENSCAFP00845031217.1, ENSCAFT00845039859.1

Conserved Domains (2) summary

smart00186
Location:280 → 493

FBG; Fibrinogen-related domains (FReDs)

cl25732
Location:77 → 294

SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051820.1 Reference ROS_Cfam_1.0

Range

57592625..57645271

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038688893.1 → XP_038544821.1 angiopoietin-2 isoform X1

Conserved Domains (2) summary

pfam15921
Location:77 → 257

CCDC158; Coiled-coil domain-containing protein 158

cl00085
Location:280 → 309

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...