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BCR BCR activator of RhoGEF and GTPase [ Canis lupus familiaris (dog) ]

Gene ID: 607482, updated on 1-Mar-2025
Official Symbol
BCRprovided by VGNC
Official Full Name
BCR activator of RhoGEF and GTPaseprovided by VGNC
Primary source
VGNC:VGNC:38420
See related
Ensembl:ENSCAFG00845021543 RGD:12120212
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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See BCR in Genome Data Viewer
Location:
chromosome: 26
Exon count:
23
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 26 NC_051830.1 (29260365..29385328)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 26 NC_006608.4 (26931961..27056311)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 26 NC_049247.1 (27950465..28075113)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 26 NC_049286.1 (27343693..27468548)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 26 NC_049767.1 (26961155..27085857)

Chromosome 26 - NC_051830.1Genomic Context describing neighboring genes Neighboring gene radial spoke head 14 homolog Neighboring gene G protein subunit alpha z Neighboring gene RAB36, member RAS oncogene family Neighboring gene uncharacterized LOC111092680 Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1 like Neighboring gene adenosine A2a receptor

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
breakpoint cluster region protein
Names
BCR, RhoGEF and GTPase activating protein
XP_013963680.2
XP_038293345.1
XP_038368216.1
XP_038431716.1
XP_038495927.1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051830.1 Reference ROS_Cfam_1.0

    Range
    29260365..29385328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038437417.1 → XP_038293345.1  breakpoint cluster region protein isoform X1

    UniProtKB/TrEMBL
    A0A8C0P2U1, A0A8C0RQL3, A0A8I3PC33, A0A8I3PH86
    Related
    ENSCAFP00845029789.1, ENSCAFT00845038017.1
    Conserved Domains (6) summary
    cd08686
    Location:935 → 1055
    C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
    PHA03307
    Location:125 → 499
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00160
    Location:521 → 711
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd04387
    Location:1074 → 1274
    RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
    pfam09036
    Location:3 → 75
    Bcr-Abl_Oligo; Bcr-Abl oncoprotein oligomerization domain
    cl17171
    Location:706 → 899
    PH-like; Pleckstrin homology-like domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049286.1 Alternate UMICH_Zoey_3.1

    Range
    27343693..27468548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038512288.1 → XP_038368216.1  breakpoint cluster region protein isoform X1

    Conserved Domains (6) summary
    cd08686
    Location:933 → 1053
    C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
    PHA03307
    Location:123 → 497
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00160
    Location:519 → 709
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd04387
    Location:1072 → 1272
    RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
    pfam09036
    Location:3 → 75
    Bcr-Abl_Oligo; Bcr-Abl oncoprotein oligomerization domain
    cl17171
    Location:704 → 897
    PH-like; Pleckstrin homology-like domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049767.1 Alternate UNSW_CanFamBas_1.0

    Range
    26961155..27085857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038639999.1 → XP_038495927.1  breakpoint cluster region protein isoform X1

    Conserved Domains (6) summary
    cd08686
    Location:935 → 1055
    C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
    PHA03307
    Location:125 → 499
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00160
    Location:521 → 711
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd04387
    Location:1074 → 1274
    RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
    pfam09036
    Location:3 → 75
    Bcr-Abl_Oligo; Bcr-Abl oncoprotein oligomerization domain
    cl17171
    Location:706 → 899
    PH-like; Pleckstrin homology-like domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049247.1 Alternate UU_Cfam_GSD_1.0

    Range
    27950465..28075113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038575788.1 → XP_038431716.1  breakpoint cluster region protein isoform X2

    UniProtKB/TrEMBL
    A0A8C0T0Y2, A0A8P0NFG7

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006608.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    26931961..27056311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014108205.3 → XP_013963680.2  breakpoint cluster region protein isoform X1

    UniProtKB/TrEMBL
    A0A8C0SZT8, A0A8C0T0Y2, A0A8P0NFG7, A0A8P0NWC3
    Conserved Domains (6) summary
    cd08686
    Location:933 → 1053
    C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
    PHA03307
    Location:123 → 497
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00160
    Location:519 → 709
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd04387
    Location:1072 → 1272
    RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
    pfam09036
    Location:3 → 75
    Bcr-Abl_Oligo; Bcr-Abl oncoprotein oligomerization domain
    cl17171
    Location:704 → 897
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
Heading Accession and Version

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