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PROK2 prokineticin 2 [ Homo sapiens (human) ]

Gene ID: 60675, updated on 13-Mar-2020

Summary

Official Symbol
PROK2provided by HGNC
Official Full Name
prokineticin 2provided by HGNC
Primary source
HGNC:HGNC:18455
See related
Ensembl:ENSG00000163421 MIM:607002
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BV8; HH4; PK2; KAL4; MIT1
Summary
This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 18.5), appendix (RPKM 9.5) and 4 other tissues See more
Orthologs

Genomic context

See PROK2 in Genome Data Viewer
Location:
3p13
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (71771655..71785148, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (71820806..71834357, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377155 Neighboring gene eukaryotic translation initiation factor 4E family member 3 Neighboring gene G protein-coupled receptor 27 Neighboring gene uncharacterized LOC105377156 Neighboring gene RNA, 7SL, cytoplasmic 271, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of prokineticin 2 (PROK2) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of MAPK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of MAPK activity TAS
Traceable Author Statement
more info
PubMed 
angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytosolic calcium ion concentration TAS
Traceable Author Statement
more info
PubMed 
positive regulation of smooth muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sensory perception of pain TAS
Traceable Author Statement
more info
PubMed 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
prokineticin-2
Names
protein Bv8 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008275.1 RefSeqGene

    Range
    5059..18552
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001126128.2NP_001119600.1  prokineticin-2 isoform a precursor

    See identical proteins and their annotated locations for NP_001119600.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC096970, BC098162
    Consensus CDS
    CCDS46868.1
    UniProtKB/Swiss-Prot
    Q9HC23
    Related
    ENSP00000295619.3, ENST00000295619.4
    Conserved Domains (1) summary
    pfam06607
    Location:23126
    Prokineticin; Prokineticin
  2. NM_021935.4NP_068754.1  prokineticin-2 isoform b precursor

    See identical proteins and their annotated locations for NP_068754.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC096970, BC069395
    Consensus CDS
    CCDS2916.1
    UniProtKB/Swiss-Prot
    Q9HC23
    Related
    ENSP00000295618.3, ENST00000353065.7
    Conserved Domains (1) summary
    pfam06607
    Location:23105
    Prokineticin; Prokineticin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    71771655..71785148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006974.1XP_016862463.1  prokineticin-2 isoform X1

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