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DHX35 DEAH-box helicase 35 [ Homo sapiens (human) ]

Gene ID: 60625, updated on 4-Dec-2022

Summary

Official Symbol
DHX35provided by HGNC
Official Full Name
DEAH-box helicase 35provided by HGNC
Primary source
HGNC:HGNC:15861
See related
Ensembl:ENSG00000101452 AllianceGenome:HGNC:15861
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DDX35; C20orf15; KAIA0875
Summary
DEAD box proteins characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The function of this gene product which is a member of this family, has not been determined. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in testis (RPKM 6.1), endometrium (RPKM 6.0) and 25 other tissues See more
Orthologs
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Genomic context

See DHX35 in Genome Data Viewer
Location:
20q11.23-q12
Exon count:
23
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (38962344..39039721)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (40692393..40769759)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (37590987..37668364)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory subunit 16B Neighboring gene RNA, 7SL, cytoplasmic 116, pseudogene Neighboring gene family with sequence similarity 83 member D Neighboring gene nucleophosmin 1 pseudogene 19 Neighboring gene Sharpr-MPRA regulatory region 15217 Neighboring gene uncharacterized LOC107985448 Neighboring gene long intergenic non-protein coding RNA 1734

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer.
EBI GWAS Catalog
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
EBI GWAS Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22759

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DHX35
Names
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 35
DEAH (Asp-Glu-Ala-His) box polypeptide 35
DEAH-box protein 35
NP_001177738.1
NP_068750.2
XP_006723911.1
XP_011527274.1
XP_011527276.1
XP_047296310.1
XP_047296311.1
XP_047296312.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190809.2NP_001177738.1  probable ATP-dependent RNA helicase DHX35 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing an in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    BC033453, DA725122
    Consensus CDS
    CCDS54463.1
    UniProtKB/Swiss-Prot
    Q9H5Z1
    Related
    ENSP00000362420.3, ENST00000373323.8
    Conserved Domains (5) summary
    smart00490
    Location:270365
    HELICc; helicase superfamily c-terminal domain
    smart00847
    Location:434518
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:21651
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:59180
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam07717
    Location:553652
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
  2. NM_021931.4NP_068750.2  probable ATP-dependent RNA helicase DHX35 isoform 1

    See identical proteins and their annotated locations for NP_068750.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC033453, DA725122
    Consensus CDS
    CCDS13310.1
    UniProtKB/Swiss-Prot
    Q9H5Z1, Q9H6T6
    Related
    ENSP00000252011.3, ENST00000252011.8
    Conserved Domains (1) summary
    COG1643
    Location:21682
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

RNA

  1. NR_033905.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate acceptor splice site at an internal exon compared to variant 1, resulting in a frame-shift. This variant is represented as non-coding because the use of the 5'-most translational initiation codon (flanked by a strong Kozak signal), as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK296793, BC033453, DA725122
    Related
    ENST00000484417.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    38962344..39039721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528972.3XP_011527274.1  probable ATP-dependent RNA helicase DHX35 isoform X1

    Conserved Domains (5) summary
    smart00490
    Location:301396
    HELICc; helicase superfamily c-terminal domain
    smart00487
    Location:53224
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:465541
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:73211
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam07717
    Location:558657
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
  2. XM_047440354.1XP_047296310.1  probable ATP-dependent RNA helicase DHX35 isoform X2

  3. XM_011528974.2XP_011527276.1  probable ATP-dependent RNA helicase DHX35 isoform X3

    Conserved Domains (3) summary
    smart00490
    Location:301396
    HELICc; helicase superfamily c-terminal domain
    smart00487
    Location:53224
    DEXDc; DEAD-like helicases superfamily
    cd00046
    Location:73211
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
  4. XM_047440355.1XP_047296311.1  probable ATP-dependent RNA helicase DHX35 isoform X4

  5. XM_047440356.1XP_047296312.1  probable ATP-dependent RNA helicase DHX35 isoform X4

  6. XM_006723848.4XP_006723911.1  probable ATP-dependent RNA helicase DHX35 isoform X5

    Conserved Domains (2) summary
    smart00847
    Location:71155
    HA2; Helicase associated domain (HA2) Add an annotation
    pfam07717
    Location:190289
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RNA

  1. XR_007067474.1 RNA Sequence

  2. XR_007067475.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    40692393..40769759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)