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Kcnq4 potassium voltage-gated channel, subfamily Q, member 4 [ Mus musculus (house mouse) ]

Gene ID: 60613, updated on 9-Sep-2018

Summary

Official Symbol
Kcnq4provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily Q, member 4provided by MGI
Primary source
MGI:MGI:1926803
See related
Ensembl:ENSMUSG00000028631 Vega:OTTMUSG00000008856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Broad expression in subcutaneous fat pad adult (RPKM 8.4), mammary gland adult (RPKM 7.6) and 22 other tissues See more
Orthologs

Genomic context

See Kcnq4 in Genome Data Viewer
Location:
4; 4 D2.2
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (120696134..120747491, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (120370078..120419781, complement)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 29891 Neighboring gene Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 Neighboring gene nuclear transcription factor-Y gamma Neighboring gene microRNA 30c-1 Neighboring gene microRNA 30e Neighboring gene microRNA 30f

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion channel activity IEA
Inferred from Electronic Annotation
more info
 
potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of synaptic transmission, dopaminergic ISO
Inferred from Sequence Orthology
more info
 
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IC
Inferred by Curator
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
potassium voltage-gated channel subfamily KQT member 4
Names
KQT-like 4
potassium channel subunit alpha KvLQT4
voltage-gated potassium channel subunit Kv7.4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081142.2NP_001074611.1  potassium voltage-gated channel subfamily KQT member 4

    See identical proteins and their annotated locations for NP_001074611.1

    Status: VALIDATED

    Source sequence(s)
    AL606924
    Consensus CDS
    CCDS38865.1
    UniProtKB/Swiss-Prot
    Q9JK97
    Related
    ENSMUSP00000030376.7, OTTMUSP00000009240, ENSMUST00000030376.7
    Conserved Domains (4) summary
    pfam00520
    Location:127331
    Ion_trans; Ion transport protein
    pfam03520
    Location:471654
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam06664
    Location:93191
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
    pfam07885
    Location:247321
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

    Range
    120696134..120747491 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240583.1XP_011238885.1  potassium voltage-gated channel subfamily KQT member 4 isoform X2

    Conserved Domains (4) summary
    pfam00520
    Location:127289
    Ion_trans; Ion transport protein
    pfam03520
    Location:429612
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam06664
    Location:93191
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
    pfam07885
    Location:225279
    Ion_trans_2; Ion channel
  2. XM_006503255.1XP_006503318.1  potassium voltage-gated channel subfamily KQT member 4 isoform X3

    Conserved Domains (3) summary
    pfam00520
    Location:127331
    Ion_trans; Ion transport protein
    pfam03520
    Location:417600
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:247321
    Ion_trans_2; Ion channel
  3. XM_011240582.1XP_011238884.1  potassium voltage-gated channel subfamily KQT member 4 isoform X1

    Conserved Domains (3) summary
    pfam00520
    Location:127331
    Ion_trans; Ion transport protein
    pfam03520
    Location:436619
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:247321
    Ion_trans_2; Ion channel
  4. XM_006503256.3XP_006503319.1  potassium voltage-gated channel subfamily KQT member 4 isoform X4

    Conserved Domains (1) summary
    pfam03520
    Location:136314
    KCNQ_channel; KCNQ voltage-gated potassium channel
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