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Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 [ Mus musculus (house mouse) ]

Gene ID: 60597, updated on 4-Jun-2024

Summary

Official Symbol
Mapk8ip2provided by MGI
Official Full Name
mitogen-activated protein kinase 8 interacting protein 2provided by MGI
Primary source
MGI:MGI:1926555
See related
Ensembl:ENSMUSG00000022619 AllianceGenome:MGI:1926555
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IB2; Jip2; 3230402N03Rik
Summary
Enables kinesin binding activity. Involved in several processes, including behavioral fear response; excitatory postsynaptic potential; and regulation of neurotransmitter receptor activity. Acts upstream of or within JNK cascade. Located in cytoplasm; neuronal cell body; and postsynaptic density. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human MAPK8IP2 (mitogen-activated protein kinase 8 interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 62.8), cortex adult (RPKM 45.8) and 7 other tissues See more
Orthologs
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Genomic context

See Mapk8ip2 in Genome Data Viewer
Location:
15 E3; 15 44.92 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89338114..89346650)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89453911..89462447)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted readthrough transcript (NMD candidate), 44502 Neighboring gene RIKEN cDNA C730034F03 gene Neighboring gene STARR-positive B cell enhancer ABC_E7406 Neighboring gene STARR-positive B cell enhancer ABC_E9159 Neighboring gene choline kinase beta Neighboring gene RIKEN cDNA C230037L18 gene Neighboring gene STARR-seq mESC enhancer starr_39466 Neighboring gene arylsulfatase A Neighboring gene SH3 and multiple ankyrin repeat domains 3 Neighboring gene predicted gene 15609

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables JUN kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP-kinase scaffold activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP-kinase scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables kinesin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in nonassociative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of AMPA receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of NMDA receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of signaling receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
C-Jun-amino-terminal kinase-interacting protein 2
Names
IB-2
JIP-2
JNK MAP kinase scaffold protein 2
JNK-interacting protein 2
islet-brain-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021921.3NP_068740.3  C-Jun-amino-terminal kinase-interacting protein 2

    See identical proteins and their annotated locations for NP_068740.3

    Status: VALIDATED

    Source sequence(s)
    AC137513, AK158968, BC029704, CA317486
    Consensus CDS
    CCDS27752.1
    UniProtKB/Swiss-Prot
    Q9CXI4, Q9ERE9
    UniProtKB/TrEMBL
    Q548W8, Q6PIT2
    Related
    ENSMUSP00000023291.6, ENSMUST00000023291.6
    Conserved Domains (2) summary
    cd11942
    Location:614668
    SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2
    cd01212
    Location:685830
    PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    89338114..89346650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)