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Gucy1a1 guanylate cyclase 1, soluble, alpha 1 [ Mus musculus (house mouse) ]

Gene ID: 60596, updated on 8-Feb-2024

Summary

Official Symbol
Gucy1a1provided by MGI
Official Full Name
guanylate cyclase 1, soluble, alpha 1provided by MGI
Primary source
MGI:MGI:1926562
See related
Ensembl:ENSMUSG00000033910 AllianceGenome:MGI:1926562
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gucy1a3; sGC-alpha1; GCS-alpha-1; GCS-alpha-3; 1200016O07Rik
Summary
Predicted to enable guanylate cyclase activity and ion binding activity. Predicted to contribute to adenylate cyclase activity and cytidylate cyclase activity. Involved in retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission. Acts upstream of or within several processes, including cGMP biosynthetic process; positive regulation of nitric oxide mediated signal transduction; and relaxation of vascular associated smooth muscle. Located in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study primary open angle glaucoma. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 25.7), CNS E18 (RPKM 15.8) and 21 other tissues See more
Orthologs
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Genomic context

See Gucy1a1 in Genome Data Viewer
Location:
3 E3; 3 35.97 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (81999734..82053253, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (82092427..82145946, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene acid-sensing ion channel family member 5 Neighboring gene guanylate cyclase 1, soluble, beta 1 Neighboring gene microRNA 7010 Neighboring gene predicted gene, 29921 Neighboring gene predicted gene, 57713

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to cytidylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables guanylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables ion binding ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cGMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cGMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of nitric oxide mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nitric oxide-cGMP-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of nitric oxide mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within relaxation of vascular associated smooth muscle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxygen levels IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of guanylate cyclase complex, soluble IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of guanylate cyclase complex, soluble ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
guanylate cyclase soluble subunit alpha-1
Names
guanylate cyclase 1, soluble, alpha 3
guanylate cyclase soluble subunit alpha-3
soluble guanylate cyclase large subunit
NP_001343916.1
NP_001343917.1
NP_068696.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356987.1NP_001343916.1  guanylate cyclase soluble subunit alpha-1

    Status: VALIDATED

    Source sequence(s)
    AC121563, BC094310, CO042590
    Consensus CDS
    CCDS17429.1
    UniProtKB/Swiss-Prot
    Q6GTG0, Q9DBQ3, Q9ERL9
    Related
    ENSMUSP00000142138.2, ENSMUST00000193924.6
    Conserved Domains (2) summary
    pfam00211
    Location:472643
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07701
    Location:277466
    HNOBA; Heme NO binding associated
  2. NM_001356988.1NP_001343917.1  guanylate cyclase soluble subunit alpha-1

    Status: VALIDATED

    Source sequence(s)
    AC121563, CO042590
    Consensus CDS
    CCDS17429.1
    UniProtKB/Swiss-Prot
    Q6GTG0, Q9DBQ3, Q9ERL9
    Conserved Domains (2) summary
    pfam00211
    Location:472643
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07701
    Location:277466
    HNOBA; Heme NO binding associated
  3. NM_021896.6NP_068696.2  guanylate cyclase soluble subunit alpha-1

    See identical proteins and their annotated locations for NP_068696.2

    Status: VALIDATED

    Source sequence(s)
    AC121563, AK004815, BC057327, BY150724, CO042590
    Consensus CDS
    CCDS17429.1
    UniProtKB/Swiss-Prot
    Q6GTG0, Q9DBQ3, Q9ERL9
    Related
    ENSMUSP00000048918.7, ENSMUST00000048976.8
    Conserved Domains (2) summary
    pfam00211
    Location:472643
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07701
    Location:277466
    HNOBA; Heme NO binding associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    81999734..82053253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)