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SCOC short coiled-coil protein [ Homo sapiens (human) ]

Gene ID: 60592, updated on 6-Sep-2021

Summary

Official Symbol
SCOCprovided by HGNC
Official Full Name
short coiled-coil proteinprovided by HGNC
Primary source
HGNC:HGNC:20335
See related
Ensembl:ENSG00000153130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCOCO; UNC-69; HRIHFB2072
Summary
This gene encodes a short coiled-coiled domain-containing protein that localizes to the Golgi apparatus. The encoded protein interacts with ADP-ribosylation factor-like proteins. Pseudogenes of this gene are found on chromosomes 1 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Expression
Ubiquitous expression in brain (RPKM 55.6), thyroid (RPKM 34.6) and 25 other tissues See more
Orthologs
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Genomic context

See SCOC in Genome Data Viewer
Location:
4q31.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (140257308..140385728)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (141178462..141306882)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene mastermind like transcriptional coactivator 3 Neighboring gene uncharacterized LOC105377452 Neighboring gene uncharacterized LOC101927516 Neighboring gene SCOC antisense RNA 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 9 Neighboring gene ribosomal protein L14 pseudogene 3 Neighboring gene calmegin Neighboring gene MGAT4 family member D

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of macroautophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein complex stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
colocalizes_with trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001153446.1NP_001146918.1  short coiled-coil protein isoform 4

    See identical proteins and their annotated locations for NP_001146918.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (4) with a distinct and shorter N-terminus, compared to isoform 1. Variants 4, 5 and 6 encode the same isoform.
    Source sequence(s)
    AA213765, AF448857, DB204055
    Consensus CDS
    CCDS3750.1
    UniProtKB/Swiss-Prot
    Q9UIL1
    Related
    ENSP00000345262.4, ENST00000338517.8
    Conserved Domains (1) summary
    pfam10224
    Location:42113
    DUF2205; Predicted coiled-coil protein (DUF2205)
  2. NM_001153484.2NP_001146956.2  short coiled-coil protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC093671
    Consensus CDS
    CCDS54806.1
    Related
    ENSP00000477352.2, ENST00000608372.6
    Conserved Domains (1) summary
    pfam10224
    Location:1373
    DUF2205; Predicted coiled-coil protein (DUF2205)
  3. NM_001153552.2NP_001147024.2  short coiled-coil protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter compared to isoform 1.
    Source sequence(s)
    AC093671
    Consensus CDS
    CCDS54807.1
    Related
    ENSP00000426649.2, ENST00000506597.2
    Conserved Domains (1) summary
    pfam10224
    Location:145
    DUF2205; Predicted coiled-coil protein (DUF2205)
  4. NM_001153585.1NP_001147057.1  short coiled-coil protein isoform 4

    See identical proteins and their annotated locations for NP_001147057.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (4) with a distinct and shorter N-terminus, compared to isoform 1. Variants 4, 5 and 6 encode the same isoform.
    Source sequence(s)
    AA213765, BC016511, DA625782
    Consensus CDS
    CCDS3750.1
    UniProtKB/Swiss-Prot
    Q9UIL1
    Related
    ENSP00000377753.3, ENST00000394203.7
    Conserved Domains (1) summary
    pfam10224
    Location:42113
    DUF2205; Predicted coiled-coil protein (DUF2205)
  5. NM_001153635.1NP_001147107.1  short coiled-coil protein isoform 5

    See identical proteins and their annotated locations for NP_001147107.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, has multiple differences in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA213765, BC062684, BG151522, DB204055
    UniProtKB/Swiss-Prot
    Q9UIL1
    Conserved Domains (1) summary
    pfam10224
    Location:42112
    DUF2205; Predicted coiled-coil protein (DUF2205)
  6. NM_001153663.1NP_001147135.1  short coiled-coil protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AA213765, BC016511, CN367654, DB465370
    UniProtKB/Swiss-Prot
    Q9UIL1
    Conserved Domains (1) summary
    pfam10224
    Location:79149
    DUF2205; Predicted coiled-coil protein (DUF2205)
  7. NM_001153690.1NP_001147162.1  short coiled-coil protein isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, has multiple differences in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (6) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA213765, BC016511, BU070009, DA625782
    UniProtKB/Swiss-Prot
    Q9UIL1
    Conserved Domains (1) summary
    pfam10224
    Location:4085
    DUF2205; Predicted coiled-coil protein (DUF2205)
  8. NM_032547.3NP_115936.2  short coiled-coil protein isoform 4

    See identical proteins and their annotated locations for NP_115936.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (4) with a distinct and shorter N-terminus, compared to isoform 1. Variants 4, 5 and 6 encode the same isoform.
    Source sequence(s)
    AA213765, AC093671, AC114771, AK027797
    Consensus CDS
    CCDS3750.1
    UniProtKB/Swiss-Prot
    Q9UIL1
    Related
    ENSP00000377755.3, ENST00000394205.7
    Conserved Domains (1) summary
    pfam10224
    Location:42113
    DUF2205; Predicted coiled-coil protein (DUF2205)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    140257308..140385728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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