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Epha8 Eph receptor A8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60589, updated on 8-Apr-2026
Official Symbol
Epha8provided by RGD
Official Full Name
Eph receptor A8provided by RGD
Primary source
RGD:708543
See related
Ensembl:ENSRNOG00000013036 AllianceGenome:RGD:708543
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GPI-linked ephrin receptor activity and growth factor binding activity. Predicted to be involved in several processes, including ephrin receptor signaling pathway; neuron development; and positive regulation of intracellular signal transduction. Predicted to act upstream of or within cellular response to follicle-stimulating hormone stimulus. Predicted to be located in neuron projection. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Orthologous to human EPHA8 (EPH receptor A8). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Brain (RPKM 14.2), Testes (RPKM 2.6) and 2 other tissues See more
Orthologs
Try the new Gene page
Try the new Transcripts and proteins table
See Epha8 in Genome Data Viewer
Location:
5q36
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (154449566..154476966, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (149166107..149193515, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (155293731..155321016, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487087 Neighboring gene complement C1q A chain Neighboring gene zinc finger and BTB domain containing 40 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102552931

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GPI-linked ephrin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables GPI-linked ephrin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ephrin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ephrin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cellular response to follicle-stimulating hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in ephrin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell adhesion mediated by integrin ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in substrate-dependent cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in substrate-dependent cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of signaling receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
ephrin type-A receptor 8
Names
EPH- and ELK-related kinase
tyrosine-protein kinase receptor EEK
NP_001406194.1
XP_008762544.2
XP_063144406.1
XP_063144407.1
XP_063144408.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419265.2NP_001406194.1  ephrin type-A receptor 8 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    F1LMX3
    Related
    ENSRNOP00000017559.5, ENSRNOT00000017559.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    154449566..154476966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764322.3XP_008762544.2  ephrin type-A receptor 8 isoform X1

    UniProtKB/TrEMBL
    A6ITC7
    Conserved Domains (5) summary
    cd09550
    Location:858920
    SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
    cd00063
    Location:365456
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:255348
    fn3; Fibronectin type III domain
    cl02704
    Location:1128
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    cl21453
    Location:555821
    PKc_like; Protein Kinases, catalytic domain
  2. XM_063288336.1XP_063144406.1  ephrin type-A receptor 8 isoform X2

  3. XM_063288337.1XP_063144407.1  ephrin type-A receptor 8 isoform X3

  4. XM_063288338.1XP_063144408.1  ephrin type-A receptor 8 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001191870.1: Suppressed sequence

    Description
    NM_001191870.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.