Format

Send to:

Choose Destination

Il1rn interleukin 1 receptor antagonist [ Rattus norvegicus (Norway rat) ]

Gene ID: 60582, updated on 22-Nov-2020

Summary

Official Symbol
Il1rnprovided by RGD
Official Full Name
interleukin 1 receptor antagonistprovided by RGD
Primary source
RGD:621159
See related
Ensembl:ENSRNOG00000005871
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IL-1ra
Summary
binds to IL-1 receptor, blocking the binding of IL-1 alpha and -beta [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 37.2), Lung (RPKM 29.2) and 6 other tissues See more
Orthologs

Genomic context

See Il1rn in Genome Data Viewer
Location:
3p13
Exon count:
7
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (1449778..1468624)
106 current Rn_Celera (GCF_000002265.2) 3 AC_000071.1 (1959290..1964693)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (1445598..1461452)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene interleukin 36, beta Neighboring gene interleukin 36 receptor antagonist Neighboring gene interleukin 1 family member 10 Neighboring gene pleckstrin and Sec7 domain containing 4 Neighboring gene uncharacterized LOC102549321 Neighboring gene paired box 8

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
interleukin-1 receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1 receptor antagonist activity ISO
Inferred from Sequence Orthology
more info
 
interleukin-1 receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-1 receptor binding ISO
Inferred from Sequence Orthology
more info
 
interleukin-1 type I receptor antagonist activity IEA
Inferred from Electronic Annotation
more info
 
interleukin-1 type I receptor antagonist activity ISO
Inferred from Sequence Orthology
more info
 
interleukin-1 type II receptor antagonist activity IEA
Inferred from Electronic Annotation
more info
 
interleukin-1 type II receptor antagonist activity ISO
Inferred from Sequence Orthology
more info
 
interleukin-1, type I receptor binding IEA
Inferred from Electronic Annotation
more info
 
interleukin-1, type I receptor binding ISO
Inferred from Sequence Orthology
more info
 
interleukin-1, type I receptor binding TAS
Traceable Author Statement
more info
PubMed 
interleukin-1, type II receptor binding IEA
Inferred from Electronic Annotation
more info
 
interleukin-1, type II receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acute-phase response ISO
Inferred from Sequence Orthology
more info
 
carboxylic acid metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to norepinephrine stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
chronic inflammatory response to antigenic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
fever generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
inflammatory response to antigenic stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin secretion ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of glutamate secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-1-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of interleukin-1-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of signal transduction TAS
Traceable Author Statement
more info
PubMed 
positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
response to interleukin-4 IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to organonitrogen compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interleukin-1 receptor antagonist protein
Names
IL-1RN
IL1 inhibitor
IRAP

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022194.2NP_071530.1  interleukin-1 receptor antagonist protein precursor

    See identical proteins and their annotated locations for NP_071530.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070930, CK364274
    UniProtKB/Swiss-Prot
    P25086
    Conserved Domains (1) summary
    smart00125
    Location:34175
    IL1; Interleukin-1 homologues

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    1449778..1468624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233636.3XP_006233698.1  interleukin-1 receptor antagonist protein isoform X1

    See identical proteins and their annotated locations for XP_006233698.1

    UniProtKB/TrEMBL
    A0A0H2UHE2
    Related
    ENSRNOP00000007949.5, ENSRNOT00000007949.6
    Conserved Domains (1) summary
    smart00125
    Location:15156
    IL1; Interleukin-1 homologues
  2. XM_006233638.3XP_006233700.1  interleukin-1 receptor antagonist protein isoform X2

    See identical proteins and their annotated locations for XP_006233700.1

    Conserved Domains (1) summary
    smart00125
    Location:1140
    IL1; Interleukin-1 homologues
  3. XM_006233637.3XP_006233699.1  interleukin-1 receptor antagonist protein isoform X2

    See identical proteins and their annotated locations for XP_006233699.1

    Conserved Domains (1) summary
    smart00125
    Location:1140
    IL1; Interleukin-1 homologues

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    1959290..1964693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center