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Syt8 synaptotagmin 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60566, updated on 5-Jun-2021

Summary

Official Symbol
Syt8provided by RGD
Official Full Name
synaptotagmin 8provided by RGD
Primary source
RGD:68399
See related
Ensembl:ENSRNOG00000020245
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
brain-specific Ca2+/phospholipid-binding proteins [RGD, Feb 2006]
Expression
Biased expression in Heart (RPKM 5.9), Muscle (RPKM 4.5) and 6 other tissues See more
Orthologs
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Genomic context

See Syt8 in Genome Data Viewer
Location:
1q41
Exon count:
9
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (197588126..197593598)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (215605408..215607602)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097365 Neighboring gene U6 spliceosomal RNA Neighboring gene troponin I2, fast skeletal type Neighboring gene lymphocyte-specific protein 1 Neighboring gene proline rich 33

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT enables calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables clathrin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT enables syntaxin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in acrosome reaction IEA
Inferred from Electronic Annotation
more info
 
involved_in acrosome reaction ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion-regulated exocytosis of neurotransmitter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium-ion regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of dopamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in dense core granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
synaptotagmin-8
Names
synaptotagmin VIII
sytVIII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053325.2NP_445777.2  synaptotagmin-8

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000044
    Related
    ENSRNOP00000027454.4, ENSRNOT00000027454.5
    Conserved Domains (2) summary
    cl14603
    Location:234364
    C2; C2 domain
    cl41733
    Location:2772
    Syt1_2_N; N-terminal domain of synaptotagmin-1 and -2

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    197588126..197593598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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