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NAA35 N-alpha-acetyltransferase 35, NatC auxiliary subunit [ Homo sapiens (human) ]

Gene ID: 60560, updated on 5-Aug-2022

Summary

Official Symbol
NAA35provided by HGNC
Official Full Name
N-alpha-acetyltransferase 35, NatC auxiliary subunitprovided by HGNC
Primary source
HGNC:HGNC:24340
See related
Ensembl:ENSG00000135040 MIM:619438; AllianceGenome:HGNC:24340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EGAP; MAK10; MAK10P; bA379P1.1
Summary
Involved in negative regulation of apoptotic process. Located in cytosol; nucleoplasm; and plasma membrane. Part of NatC complex. Colocalizes with polysome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 7.0), colon (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

See NAA35 in Genome Data Viewer
Location:
9q21.33
Exon count:
25
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (85941146..86025462)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (98091673..98175989)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (88556061..88640377)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene PHB1 pseudogene 7 Neighboring gene ribosomal L1 domain-containing protein 1-like Neighboring gene golgi membrane protein 1 Neighboring gene Sharpr-MPRA regulatory region 3020 Neighboring gene uncharacterized LOC101927623 Neighboring gene chromosome 4 open reading frame 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21613, FLJ22643

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in N-terminal peptidyl-methionine acetylation IC
Inferred by Curator
more info
PubMed 
involved_in N-terminal protein amino acid acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of NatC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NatC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NatC complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytoplasm IC
Inferred by Curator
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
N-alpha-acetyltransferase 35, NatC auxiliary subunit
Names
MAK10 homolog, amino-acid N-acetyltransferase subunit
corneal wound healing-related protein
embryonic growth-associated protein homolog
protein MAK10 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321881.2NP_001308810.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit

    Status: VALIDATED

    Source sequence(s)
    AK026296, AK292239, AL161447, BC117429
    Consensus CDS
    CCDS6673.1
    UniProtKB/Swiss-Prot
    Q5VZE5, Q9H703
    UniProtKB/TrEMBL
    A8K874
    Conserved Domains (1) summary
    pfam04112
    Location:46181
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
  2. NM_001321882.2NP_001308811.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit

    Status: VALIDATED

    Source sequence(s)
    AL161447, AL161453, AL353743
    Consensus CDS
    CCDS6673.1
    UniProtKB/Swiss-Prot
    Q5VZE5, Q9H703
    Conserved Domains (1) summary
    pfam04112
    Location:46181
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
  3. NM_024635.4NP_078911.3  N-alpha-acetyltransferase 35, NatC auxiliary subunit

    See identical proteins and their annotated locations for NP_078911.3

    Status: VALIDATED

    Source sequence(s)
    AL161447, BC117427, CA945233, DB023442
    Consensus CDS
    CCDS6673.1
    UniProtKB/Swiss-Prot
    Q5VZE5, Q9H703
    Related
    ENSP00000354972.5, ENST00000361671.10
    Conserved Domains (1) summary
    pfam04112
    Location:46181
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    85941146..86025462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252127.5XP_005252184.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X1

    See identical proteins and their annotated locations for XP_005252184.1

    UniProtKB/Swiss-Prot
    Q5VZE5, Q9H703
    Conserved Domains (1) summary
    pfam04112
    Location:46181
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
  2. XM_047423710.1XP_047279666.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X2

  3. XM_024447648.2XP_024303416.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X3

  4. XM_024447649.2XP_024303417.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    98091673..98175989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_021929.1: Suppressed sequence

    Description
    NM_021929.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.