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NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit [ Homo sapiens (human) ]

Gene ID: 60560, updated on 17-Jun-2019

Summary

Official Symbol
NAA35provided by HGNC
Official Full Name
N(alpha)-acetyltransferase 35, NatC auxiliary subunitprovided by HGNC
Primary source
HGNC:HGNC:24340
See related
Ensembl:ENSG00000135040
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EGAP; MAK10; MAK10P; bA379P1.1
Expression
Ubiquitous expression in brain (RPKM 7.0), colon (RPKM 6.9) and 25 other tissues See more
Orthologs

Genomic context

See NAA35 in Genome Data Viewer
Location:
9q21.33
Exon count:
26
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (85941142..86026355)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (88556009..88638350)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene prohibitin pseudogene 7 Neighboring gene ribosomal L1 domain-containing protein 1-like Neighboring gene golgi membrane protein 1 Neighboring gene uncharacterized LOC101927623 Neighboring gene chromosome 4 open reading frame 3 pseudogene Neighboring gene chromosome 9 open reading frame 153 Neighboring gene RN7SK pseudogene 264

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Retrograde transport at the Trans-Golgi-Network, organism-specific biosystem (from REACTOME)
    Retrograde transport at the Trans-Golgi-Network, organism-specific biosystemThe trans-Golgi network is the docking site for retrograde cargo from the endolysosomal system and the plasma membrane. Typical cargo includes recycling resident TGN proteins such as TGOLN2 (also kn...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21613, FLJ22643

Gene Ontology Provided by GOA

Function Evidence Code Pubs
peptide alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
N-terminal peptidyl-methionine acetylation IEA
Inferred from Electronic Annotation
more info
 
N-terminal protein amino acid acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
NatC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NatC complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with polysome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
N-alpha-acetyltransferase 35, NatC auxiliary subunit
Names
MAK10 homolog, amino-acid N-acetyltransferase subunit
corneal wound healing-related protein
embryonic growth-associated protein homolog
protein MAK10 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321881.1NP_001308810.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit

    Status: VALIDATED

    Source sequence(s)
    AK026296, AK292239, BC117429
    Consensus CDS
    CCDS6673.1
    UniProtKB/Swiss-Prot
    Q5VZE5
    UniProtKB/TrEMBL
    A8K874
    Conserved Domains (1) summary
    pfam04112
    Location:46181
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
  2. NM_001321882.1NP_001308811.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit

    Status: VALIDATED

    Source sequence(s)
    AL161447, AL161453, AL353743
    Consensus CDS
    CCDS6673.1
    UniProtKB/Swiss-Prot
    Q5VZE5
    Conserved Domains (1) summary
    pfam04112
    Location:46181
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
  3. NM_024635.4NP_078911.3  N-alpha-acetyltransferase 35, NatC auxiliary subunit

    See identical proteins and their annotated locations for NP_078911.3

    Status: VALIDATED

    Source sequence(s)
    AL161447, BC117427, CA945233, DB023442
    Consensus CDS
    CCDS6673.1
    UniProtKB/Swiss-Prot
    Q5VZE5
    Related
    ENSP00000354972.5, ENST00000361671.9
    Conserved Domains (1) summary
    pfam04112
    Location:46181
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    85941142..86026355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518903.3XP_011517205.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X3

  2. XM_005252127.4XP_005252184.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X1

    See identical proteins and their annotated locations for XP_005252184.1

    UniProtKB/Swiss-Prot
    Q5VZE5
    Conserved Domains (1) summary
    pfam04112
    Location:46181
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
  3. XM_017015012.1XP_016870501.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X2

  4. XM_011518904.3XP_011517206.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X4

  5. XM_024447648.1XP_024303416.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X3

  6. XM_024447649.1XP_024303417.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_021929.1: Suppressed sequence

    Description
    NM_021929.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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