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SPCS3 signal peptidase complex subunit 3 [ Homo sapiens (human) ]

Gene ID: 60559, updated on 23-Sep-2022

Summary

Official Symbol
SPCS3provided by HGNC
Official Full Name
signal peptidase complex subunit 3provided by HGNC
Primary source
HGNC:HGNC:26212
See related
Ensembl:ENSG00000129128 MIM:618854; AllianceGenome:HGNC:26212
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPC3; SPC22; SPC23; PRO3567; YLR066W; SPC22/23
Summary
Predicted to enable peptidase activity. Involved in proteolysis and viral protein processing. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 45.3), appendix (RPKM 34.4) and 25 other tissues See more
Orthologs
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Genomic context

See SPCS3 in Genome Data Viewer
Location:
4q34.2
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (176319966..176332245)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (179659012..179671286)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (177241117..177253396)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box containing 5 Neighboring gene CRISPRi-validated cis-regulatory element chr4.3423 Neighboring gene uncharacterized LOC124900817 Neighboring gene cutaneous T cell lymphoma-associated antigen 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of signal peptidase complex subunit 3 homolog (SPCS3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with signal peptidase complex subunit 3 homolog (SPCS3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22649, DKFZp564J1864

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal peptide processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in viral protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of signal peptidase complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
signal peptidase complex subunit 3
Names
SPase 22 kDa subunit
SPase 22/23 kDa subunit
microsomal signal peptidase 22/23 kDa subunit
microsomal signal peptidase 23 kDa subunit
signal peptidase complex subunit 3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021928.4NP_068747.1  signal peptidase complex subunit 3

    See identical proteins and their annotated locations for NP_068747.1

    Status: VALIDATED

    Source sequence(s)
    AC019163, AK026302
    Consensus CDS
    CCDS54823.1
    UniProtKB/Swiss-Prot
    P61009, Q9H0S7
    Related
    ENSP00000427463.1, ENST00000503362.2
    Conserved Domains (1) summary
    pfam04573
    Location:4173
    SPC22; Signal peptidase subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    176319966..176332245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    179659012..179671286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)