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SPCS3 signal peptidase complex subunit 3 [ Homo sapiens (human) ]

Gene ID: 60559, updated on 7-Jun-2020

Summary

Official Symbol
SPCS3provided by HGNC
Official Full Name
signal peptidase complex subunit 3provided by HGNC
Primary source
HGNC:HGNC:26212
See related
Ensembl:ENSG00000129128 MIM:618854
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPC3; SPC22; SPC23; PRO3567; YLR066W; SPC22/23
Expression
Ubiquitous expression in thyroid (RPKM 45.3), appendix (RPKM 34.4) and 25 other tissues See more
Orthologs

Genomic context

See SPCS3 in Genome Data Viewer
Location:
4q34.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (176319966..176332245)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (177241090..177253396)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box containing 5 Neighboring gene CRISPRi-validated cis-regulatory element chr4.3423 Neighboring gene cutaneous T cell lymphoma-associated antigen 1 pseudogene Neighboring gene uncharacterized LOC105377555 Neighboring gene vascular endothelial growth factor C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of signal peptidase complex subunit 3 homolog (SPCS3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with signal peptidase complex subunit 3 homolog (SPCS3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22649, DKFZp564J1864

Gene Ontology Provided by GOA

Function Evidence Code Pubs
peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
signal peptidase complex subunit 3
Names
SPase 22 kDa subunit
SPase 22/23 kDa subunit
microsomal signal peptidase 22/23 kDa subunit
microsomal signal peptidase 23 kDa subunit
signal peptidase complex subunit 3 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021928.4NP_068747.1  signal peptidase complex subunit 3

    See identical proteins and their annotated locations for NP_068747.1

    Status: VALIDATED

    Source sequence(s)
    AC019163, AK026302
    Consensus CDS
    CCDS54823.1
    UniProtKB/Swiss-Prot
    P61009
    Related
    ENSP00000427463.1, ENST00000503362.2
    Conserved Domains (1) summary
    pfam04573
    Location:4173
    SPC22; Signal peptidase subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    176319966..176332245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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