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AGBL5 AGBL carboxypeptidase 5 [ Homo sapiens (human) ]

Gene ID: 60509, updated on 24-Nov-2021

Summary

Official Symbol
AGBL5provided by HGNC
Official Full Name
AGBL carboxypeptidase 5provided by HGNC
Primary source
HGNC:HGNC:26147
See related
Ensembl:ENSG00000084693 MIM:615900
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCP5; RP75
Summary
This gene encodes a metallocarboxypeptidase involved in protein deglutamylation and a member of the peptidase M14 family of proteins. The encoded protein has been described as a "dual-functional" deglutamylase that can remove glutamate residues from both carboxyl termini and side chains of protein substrates. This deglutamylase activity may be important in antiviral immunity. Mutations in this gene are associated with retinitis pigmentosa. [provided by RefSeq, Jul 2016]
Expression
Biased expression in testis (RPKM 145.3), thyroid (RPKM 14.3) and 7 other tissues See more
Orthologs
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Genomic context

See AGBL5 in Genome Data Viewer
Location:
2p23.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (27051423..27070620)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27274291..27293486)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene AGBL5 antisense RNA 1 Neighboring gene tRNA-Tyr (anticodon GTA) 2-1 Neighboring gene oligosaccharyltransferase complex subunit 4, non-catalytic Neighboring gene elastin microfibril interfacer 1 Neighboring gene ketohexokinase Neighboring gene cell growth regulator with EF-hand domain 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ATP/GTP binding protein-like 5 (AGBL5) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21839

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metallocarboxypeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein branching point deglutamylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein deglutamylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cytosolic carboxypeptidase-like protein 5
Names
ATP/GTP binding protein like 5
cytosolic carboxypeptidase 5
NP_001030584.1
NP_068603.4
XP_005264534.1
XP_011531313.1
XP_011531314.1
XP_011531315.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052914.1 RefSeqGene

    Range
    5246..24196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001035507.3NP_001030584.1  cytosolic carboxypeptidase-like protein 5 isoform 3

    See identical proteins and their annotated locations for NP_001030584.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC018584, DA901318
    Consensus CDS
    CCDS42665.1
    UniProtKB/Swiss-Prot
    Q8NDL9
    Related
    ENSP00000323681.8, ENST00000323064.12
    Conserved Domains (1) summary
    cd06236
    Location:176568
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
  2. NM_021831.6NP_068603.4  cytosolic carboxypeptidase-like protein 5 isoform 1

    See identical proteins and their annotated locations for NP_068603.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL833844, DA901318
    Consensus CDS
    CCDS1732.3
    UniProtKB/Swiss-Prot
    Q8NDL9
    Related
    ENSP00000353249.4, ENST00000360131.5
    Conserved Domains (1) summary
    cd06236
    Location:176568
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins

RNA

  1. NR_104246.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an additional exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL833844, BC007415, DA901318
    Related
    ENST00000487078.5
  2. NR_138023.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains alternate exons in the 5' and 3' regions compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC013403, AC013472, BC007415

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    27051423..27070620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533011.3XP_011531313.1  cytosolic carboxypeptidase-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011531313.1

    UniProtKB/Swiss-Prot
    Q8NDL9
    Conserved Domains (1) summary
    cd06236
    Location:176568
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
  2. XM_005264477.3XP_005264534.1  cytosolic carboxypeptidase-like protein 5 isoform X2

    Conserved Domains (1) summary
    cd06236
    Location:176568
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
  3. XM_011533013.2XP_011531315.1  cytosolic carboxypeptidase-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011531315.1

    UniProtKB/Swiss-Prot
    Q8NDL9
    Conserved Domains (1) summary
    cd06236
    Location:176568
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
  4. XM_011533012.2XP_011531314.1  cytosolic carboxypeptidase-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011531314.1

    UniProtKB/Swiss-Prot
    Q8NDL9
    Conserved Domains (1) summary
    cd06236
    Location:176568
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
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