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RNH1 ribonuclease/angiogenin inhibitor 1 [ Homo sapiens (human) ]

Gene ID: 6050, updated on 6-Jan-2019

Summary

Official Symbol
RNH1provided by HGNC
Official Full Name
ribonuclease/angiogenin inhibitor 1provided by HGNC
Primary source
HGNC:HGNC:10074
See related
Ensembl:ENSG00000023191 MIM:173320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAI; RNH
Summary
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]
Expression
Ubiquitous expression in skin (RPKM 36.6), lung (RPKM 36.0) and 25 other tissues See more
Orthologs

Genomic context

See RNH1 in Genome Data Viewer
Location:
11p15.5
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (494512..507283, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (494512..507283, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376506 Neighboring gene anoctamin 9 Neighboring gene RNA, 7SL, cytoplasmic 838, pseudogene Neighboring gene phosphatidylserine synthase 2 Neighboring gene collagen alpha-2(IV) chain-like Neighboring gene leucine rich repeat containing 56 Neighboring gene HRas proto-oncogene, GTPase Neighboring gene uncharacterized LOC692247 Neighboring gene lamin tail domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ribonuclease/angiogenin inhibitor 1 (RNH1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with RNH1 PubMed
nucleocapsid gag HIV-1 NC is identified to have a physical interaction with ribonuclease/angiogenin inhibitor 1 (RNH1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human ribonuclease/angiogenin inhibitor 1 (RNH1) at amino acid residues 445-446 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4569, MGC18200, MGC54054

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribonuclease inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
mRNA catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
angiogenin-PRI complex IPI
Inferred from Physical Interaction
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ribonuclease inhibitor
Names
placental RNase inhibitor
placental ribonuclease inhibitor
testicular tissue protein Li 164

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002939.3NP_002930.2  ribonuclease inhibitor

    See identical proteins and their annotated locations for NP_002930.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All eight variants of this gene encode the same protein.
    Source sequence(s)
    BC047730, BM019570, BQ650217
    Consensus CDS
    CCDS7697.1
    UniProtKB/Swiss-Prot
    P13489
    UniProtKB/TrEMBL
    A0A140VJT8
    Related
    ENSP00000380739.2, ENST00000397615.6
    Conserved Domains (3) summary
    smart00368
    Location:397424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:629
    LRR_RI; leucine-rich repeat [structural motif]
  2. NM_203383.1NP_976317.1  ribonuclease inhibitor

    See identical proteins and their annotated locations for NP_976317.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
    Source sequence(s)
    BC011186, BG752774, BM019570, BQ650217
    Consensus CDS
    CCDS7697.1
    UniProtKB/Swiss-Prot
    P13489
    UniProtKB/TrEMBL
    A0A140VJT8
    Conserved Domains (3) summary
    smart00368
    Location:397424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:629
    LRR_RI; leucine-rich repeat [structural motif]
  3. NM_203384.1NP_976318.1  ribonuclease inhibitor

    See identical proteins and their annotated locations for NP_976318.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and uses a different splice site in the 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
    Source sequence(s)
    BC003506, BC011186, BM019570, BQ650217
    Consensus CDS
    CCDS7697.1
    UniProtKB/Swiss-Prot
    P13489
    UniProtKB/TrEMBL
    A0A140VJT8
    Related
    ENSP00000416589.2, ENST00000438658.6
    Conserved Domains (3) summary
    smart00368
    Location:397424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:629
    LRR_RI; leucine-rich repeat [structural motif]
  4. NM_203385.1NP_976319.1  ribonuclease inhibitor

    See identical proteins and their annotated locations for NP_976319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
    Source sequence(s)
    BC011186, BM019570, BQ650217, BQ954409
    Consensus CDS
    CCDS7697.1
    UniProtKB/Swiss-Prot
    P13489
    UniProtKB/TrEMBL
    A0A140VJT8
    Related
    ENSP00000380738.1, ENST00000397614.5
    Conserved Domains (3) summary
    smart00368
    Location:397424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:629
    LRR_RI; leucine-rich repeat [structural motif]
  5. NM_203386.2NP_976320.1  ribonuclease inhibitor

    See identical proteins and their annotated locations for NP_976320.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains a different exon and uses a different splice site in its 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
    Source sequence(s)
    AC137894, BC011186, BM465975, BQ650217
    Consensus CDS
    CCDS7697.1
    UniProtKB/Swiss-Prot
    P13489
    UniProtKB/TrEMBL
    A0A140VJT8
    Related
    ENSP00000435594.1, ENST00000533410.5
    Conserved Domains (3) summary
    smart00368
    Location:397424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:629
    LRR_RI; leucine-rich repeat [structural motif]
  6. NM_203387.3NP_976321.1  ribonuclease inhibitor

    See identical proteins and their annotated locations for NP_976321.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains a different exon in its 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
    Source sequence(s)
    AC137894, BC011186, DC296330
    Consensus CDS
    CCDS7697.1
    UniProtKB/Swiss-Prot
    P13489
    UniProtKB/TrEMBL
    A0A140VJT8
    Related
    ENSP00000346402.2, ENST00000354420.6
    Conserved Domains (3) summary
    smart00368
    Location:397424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:629
    LRR_RI; leucine-rich repeat [structural motif]
  7. NM_203388.2NP_976322.1  ribonuclease inhibitor

    See identical proteins and their annotated locations for NP_976322.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has multiple differences in its 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
    Source sequence(s)
    AC137894, BC011500, BQ650217
    Consensus CDS
    CCDS7697.1
    UniProtKB/Swiss-Prot
    P13489
    UniProtKB/TrEMBL
    A0A140VJT8
    Related
    ENSP00000380729.3, ENST00000397604.7
    Conserved Domains (3) summary
    smart00368
    Location:397424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:629
    LRR_RI; leucine-rich repeat [structural motif]
  8. NM_203389.2NP_976323.1  ribonuclease inhibitor

    See identical proteins and their annotated locations for NP_976323.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has multiple differences in its 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
    Source sequence(s)
    AC137894, BC014629, BQ650217
    Consensus CDS
    CCDS7697.1
    UniProtKB/Swiss-Prot
    P13489
    UniProtKB/TrEMBL
    A0A140VJT8
    Related
    ENSP00000348515.5, ENST00000356187.9
    Conserved Domains (3) summary
    smart00368
    Location:397424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:629
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    494512..507283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520255.1XP_011518557.1  ribonuclease inhibitor isoform X1

    See identical proteins and their annotated locations for XP_011518557.1

    UniProtKB/Swiss-Prot
    P13489
    UniProtKB/TrEMBL
    A0A140VJT8
    Conserved Domains (3) summary
    smart00368
    Location:397424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:629
    LRR_RI; leucine-rich repeat [structural motif]
  2. XM_011520260.2XP_011518562.1  ribonuclease inhibitor isoform X1

    See identical proteins and their annotated locations for XP_011518562.1

    UniProtKB/Swiss-Prot
    P13489
    UniProtKB/TrEMBL
    A0A140VJT8
    Conserved Domains (3) summary
    smart00368
    Location:397424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:629
    LRR_RI; leucine-rich repeat [structural motif]
  3. XM_011520261.2XP_011518563.1  ribonuclease inhibitor isoform X1

    See identical proteins and their annotated locations for XP_011518563.1

    UniProtKB/Swiss-Prot
    P13489
    UniProtKB/TrEMBL
    A0A140VJT8
    Conserved Domains (3) summary
    smart00368
    Location:397424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:629
    LRR_RI; leucine-rich repeat [structural motif]
  4. XM_017018106.1XP_016873595.1  ribonuclease inhibitor isoform X1

    UniProtKB/Swiss-Prot
    P13489
    UniProtKB/TrEMBL
    A0A140VJT8
    Conserved Domains (3) summary
    smart00368
    Location:397424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:629
    LRR_RI; leucine-rich repeat [structural motif]
  5. XM_011520262.3XP_011518564.1  ribonuclease inhibitor isoform X1

    See identical proteins and their annotated locations for XP_011518564.1

    UniProtKB/Swiss-Prot
    P13489
    UniProtKB/TrEMBL
    A0A140VJT8
    Conserved Domains (3) summary
    smart00368
    Location:397424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:629
    LRR_RI; leucine-rich repeat [structural motif]
  6. XM_011520258.3XP_011518560.1  ribonuclease inhibitor isoform X1

    See identical proteins and their annotated locations for XP_011518560.1

    UniProtKB/Swiss-Prot
    P13489
    UniProtKB/TrEMBL
    A0A140VJT8
    Conserved Domains (3) summary
    smart00368
    Location:397424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:629
    LRR_RI; leucine-rich repeat [structural motif]
  7. XM_011520257.3XP_011518559.1  ribonuclease inhibitor isoform X1

    See identical proteins and their annotated locations for XP_011518559.1

    UniProtKB/Swiss-Prot
    P13489
    UniProtKB/TrEMBL
    A0A140VJT8
    Conserved Domains (3) summary
    smart00368
    Location:397424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:629
    LRR_RI; leucine-rich repeat [structural motif]
  8. XM_011520263.1XP_011518565.1  ribonuclease inhibitor isoform X1

    See identical proteins and their annotated locations for XP_011518565.1

    UniProtKB/Swiss-Prot
    P13489
    UniProtKB/TrEMBL
    A0A140VJT8
    Conserved Domains (3) summary
    smart00368
    Location:397424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:629
    LRR_RI; leucine-rich repeat [structural motif]
  9. XM_011520259.3XP_011518561.1  ribonuclease inhibitor isoform X1

    See identical proteins and their annotated locations for XP_011518561.1

    UniProtKB/Swiss-Prot
    P13489
    UniProtKB/TrEMBL
    A0A140VJT8
    Related
    ENSP00000433999.1, ENST00000534797.5
    Conserved Domains (3) summary
    smart00368
    Location:397424
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:6325
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:629
    LRR_RI; leucine-rich repeat [structural motif]

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187586.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    24153..36924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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