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HAPLN2 hyaluronan and proteoglycan link protein 2 [ Homo sapiens (human) ]

Gene ID: 60484, updated on 8-Dec-2022

Summary

Official Symbol
HAPLN2provided by HGNC
Official Full Name
hyaluronan and proteoglycan link protein 2provided by HGNC
Primary source
HGNC:HGNC:17410
See related
Ensembl:ENSG00000132702 MIM:619726; AllianceGenome:HGNC:17410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRAL1
Summary
Predicted to enable hyaluronic acid binding activity. Predicted to be involved in central nervous system development and skeletal system development. Predicted to act upstream of or within establishment of blood-nerve barrier and extracellular matrix assembly. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 7.0), prostate (RPKM 0.6) and 2 other tissues See more
Orthologs
NEW
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Genomic context

See HAPLN2 in Genome Data Viewer
Location:
1q23.1
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156601504..156625725)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155755804..155762124)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156589207..156595517)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene G-patch domain containing 4 (gene/pseudogene) Neighboring gene NAD(P)HX epimerase Neighboring gene uncharacterized LOC101928177 Neighboring gene brevican Neighboring gene VISTA enhancer hs1891

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of hyaluronan and proteoglycan link protein 2 (HAPLN2) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hyaluronic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of blood-nerve barrier IEA
Inferred from Electronic Annotation
more info
 
involved_in extracellular matrix assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in node of Ranvier IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
hyaluronan and proteoglycan link protein 2
Names
brain link protein-1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021817.3NP_068589.1  hyaluronan and proteoglycan link protein 2 precursor

    See identical proteins and their annotated locations for NP_068589.1

    Status: VALIDATED

    Source sequence(s)
    AB049054, BC029864
    Consensus CDS
    CCDS1148.1
    UniProtKB/Swiss-Prot
    Q5T3J0, Q9GZV7
    Related
    ENSP00000255039.1, ENST00000255039.6
    Conserved Domains (3) summary
    cd03518
    Location:148241
    Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd03519
    Location:250337
    Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cl11960
    Location:49149
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    156601504..156625725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002020.2XP_016857509.1  hyaluronan and proteoglycan link protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5T3J0, Q9GZV7
    Conserved Domains (3) summary
    cd03518
    Location:148241
    Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd03519
    Location:250337
    Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cl11960
    Location:49149
    Ig; Immunoglobulin domain
  2. XM_047427123.1XP_047283079.1  hyaluronan and proteoglycan link protein 2 isoform X2

    UniProtKB/TrEMBL
    B7Z1R1
  3. XM_011509853.3XP_011508155.1  hyaluronan and proteoglycan link protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011508155.1

    UniProtKB/Swiss-Prot
    Q5T3J0, Q9GZV7
    Conserved Domains (3) summary
    cd03518
    Location:148241
    Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd03519
    Location:250337
    Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cl11960
    Location:49149
    Ig; Immunoglobulin domain

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791758.1 Reference GRCh38.p14 PATCHES

    Range
    177974..184284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    155755804..155762124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)