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RNF2 ring finger protein 2 [ Homo sapiens (human) ]

Gene ID: 6045, updated on 20-Jan-2019

Summary

Official Symbol
RNF2provided by HGNC
Official Full Name
ring finger protein 2provided by HGNC
Primary source
HGNC:HGNC:10061
See related
Ensembl:ENSG00000121481 MIM:608985
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAP1; DING; BAP-1; HIPI3; RING2; RING1B
Summary
Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 7.8), placenta (RPKM 6.0) and 25 other tissues See more
Orthologs

Genomic context

See RNF2 in Genome Data Viewer
Location:
1q25.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (185045419..185102608)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (185014482..185071740)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1633 Neighboring gene RNA, 5S ribosomal pseudogene 72 Neighboring gene ferritin heavy chain 1 pseudogene 25 Neighboring gene tRNA methyltransferase 1 like Neighboring gene ribosomal protein L22 pseudogene 24 Neighboring gene SWT1, RNA endoribonuclease homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Phosphorylated DING (pDING) inhibits HIV-1 Tat-induced neuronal cell injury by suppressing the activity of serine/threonine kinases p38 MAPK and Cdk5 and enhancing the activity of neuroprotective factor MEF2 through the phosphotase activity of pDING PubMed
tat HIV-1 Tat downregulates ring finger protein 2 (RNF2) in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cellular Senescence, organism-specific biosystem (from REACTOME)
    Cellular Senescence, organism-specific biosystemCellular senescence involves irreversible growth arrest accompanied by phenotypic changes such as enlarged morphology, reorganization of chromatin through formation of senescence-associated heterochr...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Oxidative Stress Induced Senescence, organism-specific biosystem (from REACTOME)
    Oxidative Stress Induced Senescence, organism-specific biosystemOxidative stress, caused by increased concentration of reactive oxygen species (ROS) in the cell, can happen as a consequence of mitochondrial dysfunction induced by the oncogenic RAS (Moiseeva et al...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • SUMO E3 ligases SUMOylate target proteins, organism-specific biosystem (from REACTOME)
    SUMO E3 ligases SUMOylate target proteins, organism-specific biosystemSUMO proteins are conjugated to lysine residues of target proteins via an isopeptide bond with the C-terminal glycine of SUMO (reviewed in Zhao 2007, Gareau and Lima 2010, Hannoun et al. 2010, Citro ...
  • SUMOylation, organism-specific biosystem (from REACTOME)
    SUMOylation, organism-specific biosystemSmall Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Ha...
  • SUMOylation of DNA damage response and repair proteins, organism-specific biosystem (from REACTOME)
    SUMOylation of DNA damage response and repair proteins, organism-specific biosystemSeveral factors that participate in DNA damage response and repair are SUMOylated (reviewed in Dou et al. 2011, Bekker-Jensen and Mailand 2011, Ulrich 2012, Psakhye and Jentsch 2012, Bologna and Ferr...
  • SUMOylation of RNA binding proteins, organism-specific biosystem (from REACTOME)
    SUMOylation of RNA binding proteins, organism-specific biosystemSUMOylation of RNA-binding proteins (Li et al. 2004, reviewed in Filosa et al. 2013) alters their interactions with nucleic acids and with proteins. Whereas SUMOylation of HNRNPC decreases its affini...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RING-like zinc finger domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
anterior/posterior axis specification IEA
Inferred from Electronic Annotation
more info
 
gastrulation with mouth forming second IEA
Inferred from Electronic Annotation
more info
 
germ cell development IEA
Inferred from Electronic Annotation
more info
 
histone H2A monoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
histone H2A-K119 monoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of G0 to G1 transition TAS
Traceable Author Statement
more info
 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
MLL1 complex IDA
Inferred from Direct Assay
more info
PubMed 
PRC1 complex IDA
Inferred from Direct Assay
more info
PubMed 
PcG protein complex IDA
Inferred from Direct Assay
more info
PubMed 
euchromatin IEA
Inferred from Electronic Annotation
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
sex chromatin IEA
Inferred from Electronic Annotation
more info
 
ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RING2
Names
HIP2-interacting protein 3
RING finger protein 1B
RING finger protein BAP-1
RING-type E3 ubiquitin transferase RING2
huntingtin-interacting protein 2-interacting protein 3
protein DinG
NP_009143.1
XP_005245470.1
XP_011508153.1
XP_011508154.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007212.4NP_009143.1  E3 ubiquitin-protein ligase RING2

    See identical proteins and their annotated locations for NP_009143.1

    Status: REVIEWED

    Source sequence(s)
    AF141327, AL109865
    Consensus CDS
    CCDS1365.1
    UniProtKB/Swiss-Prot
    Q99496
    Related
    ENSP00000356480.3, ENST00000367510.7
    Conserved Domains (3) summary
    pfam16207
    Location:246330
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
    cd16531
    Location:5191
    RING-HC_RING1_like; RING finger, HC subclass, found in really interesting new gene proteins RING1, RING2 and similar proteins
    cl26688
    Location:11103
    DWNN; DWNN domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    185045419..185102608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245413.3XP_005245470.1  E3 ubiquitin-protein ligase RING2 isoform X2

    See identical proteins and their annotated locations for XP_005245470.1

    Conserved Domains (2) summary
    cd00162
    Location:145
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam16207
    Location:188281
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
  2. XM_011509852.2XP_011508154.1  E3 ubiquitin-protein ligase RING2 isoform X1

    See identical proteins and their annotated locations for XP_011508154.1

    UniProtKB/Swiss-Prot
    Q99496
    Conserved Domains (3) summary
    pfam16207
    Location:246330
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
    cd16531
    Location:5191
    RING-HC_RING1_like; RING finger, HC subclass, found in really interesting new gene proteins RING1, RING2 and similar proteins
    cl26688
    Location:11103
    DWNN; DWNN domain
  3. XM_011509851.3XP_011508153.1  E3 ubiquitin-protein ligase RING2 isoform X1

    See identical proteins and their annotated locations for XP_011508153.1

    UniProtKB/Swiss-Prot
    Q99496
    Conserved Domains (3) summary
    pfam16207
    Location:246330
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
    cd16531
    Location:5191
    RING-HC_RING1_like; RING finger, HC subclass, found in really interesting new gene proteins RING1, RING2 and similar proteins
    cl26688
    Location:11103
    DWNN; DWNN domain
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