Glp2r glucagon-like peptide 2 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Glp2rprovided by RGD
Official Full Name: glucagon-like peptide 2 receptorprovided by RGD
Primary source: RGD:620270
See related: Ensembl:ENSRNOG00000003683 AllianceGenome:RGD:620270
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables glucagon receptor activity. Involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Orthologous to human GLP2R (glucagon like peptide 2 receptor). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Spleen (RPKM 3.0), Heart (RPKM 2.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (52901707..52964961, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (52402748..52466012, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (54260290..54323839, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our findings reveal the involvement of GLP2R via a modulation of the AKT-mTOR-p70S6K pathway in the mechanisms underlying chronic cerebral hypoperfusion-induced impairments of spatial learning and memory.
Title: Glucagon-Like Peptide-2 Receptor is Involved in Spatial Cognitive Dysfunction in Rats After Chronic Cerebral Hypoperfusion.
GLP2R expression in the rat jejunum quantified by quantitative real time PCR.
Title: The glucagon-like peptide 2 receptor is expressed in enteric neurons and not in the epithelium of the intestine.
Downregulation of IGF-1R and IGF-2R gene expression may interfere with normal alveologenesis causing pulmonary hypoplasia in the nitrofen-induced CDH model.
Title: Insulinlike growth factor receptor type 1 and type 2 are downregulated in the nitrofen-induced hypoplastic lung.
GLP-2 and several growth factors show synergistic effects on the proliferation of rat astrocytes, a process in which an enhanced expression of GLP-2R and IGF-IR may be involved
Title: Synergistic effect of glucagon-like peptide 2 (GLP-2) and of key growth factors on the proliferation of cultured rat astrocytes. Evidence for reciprocal upregulation of the mRNAs for GLP-2 and IGF-I receptors.
Glucagon-like peptide 2 stimulates glucagon secretion through GLP-2r present on the alpha cell in rats.
Title: The alpha cell expresses glucagon-like peptide-2 receptors and glucagon-like peptide-2 stimulates glucagon secretion from the rat pancreas.
presence of a functional GLP-2-GLP-2R axis in the developing rodent brain
Title: Extrahypothalamic expression of the glucagon-like peptide-2 receptor is coupled to reduction of glutamate-induced cell death in cultured hippocampal cells.
normal levels of polyamines are necessary for the expression of GLP-2-induced hyperplasia
Title: The role of polyamines in glucagon-like peptide-2 prevention of TPN-induced gut hypoplasia.
GLP-2R is expressed by vagal afferents, and intraperitoneal GLP-2 activates the vagal afferent pathway
Title: Localization and activation of glucagon-like peptide-2 receptors on vagal afferents in the rat.
Activation of the endogenous rat mucosal GLP-2 receptor is linked to activation of a cAMP/protein kinase A-dependent, growth-promoting pathway in vitro.
Title: Glucagon-like peptide-2 receptor activation in the rat intestinal mucosa.
GLP-2 in the gut acts by activating receptors on the subepithelial myofibroblasts, causing the release of growth factors, which in turn stimulate intestinal growth
Title: GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134671 (e-PCR)
- UniSTS:217950

PMC60082P1 (e-PCR)
- UniSTS:273386

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables glucagon receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucagon receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucagon stimulus	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glucagon-like peptide 2 receptor

Names: GLP-2 receptor; GLP-2-R; GLP-2R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021848.2 → NP_068620.1 glucagon-like peptide 2 receptor

See identical proteins and their annotated locations for NP_068620.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q9Z0W0

UniProtKB/TrEMBL

A6HFJ0, A6HFJ1

Related

ENSRNOP00000004946.4, ENSRNOT00000004946.7

Conserved Domains (2) summary

pfam00002
Location:175 → 432

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:93 → 162

HRM; Hormone receptor domain