Format

Send to:

Choose Destination

EXOC4 exocyst complex component 4 [ Homo sapiens (human) ]

Gene ID: 60412, updated on 21-Dec-2019

Summary

Official Symbol
EXOC4provided by HGNC
Official Full Name
exocyst complex component 4provided by HGNC
Primary source
HGNC:HGNC:30389
See related
Ensembl:ENSG00000131558 MIM:608185
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEC8; Sec8p; SEC8L1
Summary
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 6.6), brain (RPKM 6.1) and 25 other tissues See more
Orthologs

Genomic context

See EXOC4 in Genome Data Viewer
Location:
7q33
Exon count:
23
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (133253067..134067137)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (132937823..133750514)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375512 Neighboring gene ST13, Hsp70 interacting protein pseudogene 7 Neighboring gene ribosomal protein S15a pseudogene 23 Neighboring gene microRNA 6133 Neighboring gene RPS3A pseudogene 27 Neighboring gene uncharacterized LOC101928861 Neighboring gene cytochrome c oxidase subunit 5B pseudogene 3 Neighboring gene uncharacterized LOC105375513 Neighboring gene uncharacterized LOC105375514 Neighboring gene leucine rich repeats and guanylate kinase domain containing

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness.
NHGRI GWA Catalog
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef-mediated actin rearrangement is inhibited by EXOC4 PubMed
nef HIV-1 Nef interacts with EXOC4 and this interaction is dependent on the GTPase interaction site of PAK2 PubMed
nef HIV-1 Nef is identified to have a physical interaction with exocyst complex component 4 (EXOC4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
nef HIV-1 Nef immunocomplexes analyzed by mass spectrometry reveal that exocyst complex component 4 (EXOC4) is a Nef-binding protein in Jurkat cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC27170

Gene Ontology Provided by GOA

Function Evidence Code Pubs
PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 
Ral GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
paraxial mesoderm formation IEA
Inferred from Electronic Annotation
more info
 
protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of macroautophagy TAS
Traceable Author Statement
more info
PubMed 
vesicle docking involved in exocytosis IEA
Inferred from Electronic Annotation
more info
 
vesicle tethering involved in exocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Flemming body IEA
Inferred from Electronic Annotation
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
exocyst IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth cone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
microvillus IEA
Inferred from Electronic Annotation
more info
 
myelin sheath abaxonal region IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
exocyst complex component 4
Names
SEC8-like 1
exocyst complex component Sec8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047176.1 RefSeqGene

    Range
    5012..817695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001037126.1NP_001032203.1  exocyst complex component 4 isoform b

    See identical proteins and their annotated locations for NP_001032203.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple exons in the 3' coding region and has a unique 3' UTR, compared to variant 1. This variant encodes isoform b which is much shorter than isoform a.
    Source sequence(s)
    AW451395, BC067263, BE246205
    Consensus CDS
    CCDS43648.1
    UniProtKB/TrEMBL
    Q6NX51
    Related
    ENSP00000376868.2, ENST00000393161.6
    Conserved Domains (1) summary
    pfam04048
    Location:57143
    Sec8_exocyst; Sec8 exocyst complex component specific domain
  2. NM_021807.4NP_068579.3  exocyst complex component 4 isoform a

    See identical proteins and their annotated locations for NP_068579.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AF132734, AK027688
    Consensus CDS
    CCDS5829.1
    UniProtKB/Swiss-Prot
    Q96A65
    Related
    ENSP00000253861.4, ENST00000253861.5
    Conserved Domains (1) summary
    pfam04048
    Location:57143
    Sec8_exocyst; Sec8 exocyst complex component specific domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    133253067..134067137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250523.5XP_005250580.1  exocyst complex component 4 isoform X2

    Conserved Domains (1) summary
    pfam04048
    Location:57143
    Sec8_exocyst; Sec8 exocyst complex component specific domain
  2. XM_017012494.2XP_016867983.1  exocyst complex component 4 isoform X1

RNA

  1. XR_001744845.2 RNA Sequence

Support Center