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Cdkl3 cyclin-dependent kinase-like 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60396, updated on 6-Jul-2026
Symbol
Cdkl3provided by RGD
Full Name
cyclin-dependent kinase-like 3provided by RGD
Primary source
RGD:619874
See related
Ensembl:ENSRNOG00000059485 AllianceGenome:RGD:619874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nkiatre; Nkiatreb
Summary
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within dendrite extension; negative regulation of axon extension; and positive regulation of dendrite morphogenesis. Located in cytoplasm and nucleus. Orthologous to human CDKL3 (cyclin dependent kinase like 3). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Testes (RPKM 93.4), Brain (RPKM 20.5) and 8 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Cdkl3 in Genome Data Viewer
Location:
10q22
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (36755413..36850197)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (36263212..36349268)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene XRN2 binding domain containing 1 Neighboring gene ubiquitin-conjugating enzyme E2B Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene protein phosphatase 2 catalytic subunit alpha Neighboring gene protein FAM162A-like Neighboring gene S-phase kinase-associated protein 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. NKIATRE is a novel conserved cdc2-related kinase. Haq R, et al. Genomics, 2001 Jan 15. PMID 11161806
  2. Non-syndromic mild mental retardation candidate gene CDKL3 regulates neuronal morphogenesis. Liu Z, et al. Neurobiol Dis, 2010 Sep. PMID 20347982
  3. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in dendrite extension IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendrite extension IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dendrite extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dendrite extension ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of axon extension IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of axon extension IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of axon extension ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
cyclin-dependent kinase-like 3
Names
serine/threonine kinase NKIATRE beta
serine/threonine protein kinase NKIATRE
NP_068540.1
XP_008772105.1
XP_008772106.1
XP_008772107.1
XP_008772108.1
XP_008772111.1
XP_017458018.1
XP_017458020.1
XP_038942663.1
XP_038942665.1
XP_038942666.1
XP_038942667.1
XP_063125824.1
XP_063125826.1
XP_063125827.1
XP_063125828.1
XP_063125829.1
XP_063125830.1
XP_063125832.1
XP_063125833.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021772.2 → NP_068540.1  cyclin-dependent kinase-like 3

    See identical proteins and their annotated locations for NP_068540.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    Conserved Domains (2) summary
    smart00220
    Location:4 → 286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    36755413..36850197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086738.2 → XP_038942666.1  cyclin-dependent kinase-like 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZUY6, A0A8I6GKT9
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  2. XM_063269760.1 → XP_063125830.1  cyclin-dependent kinase-like 3 isoform X7

    UniProtKB/TrEMBL
    A0A8I6GKT9

  3. XM_063269762.1 → XP_063125832.1  cyclin-dependent kinase-like 3 isoform X8

    UniProtKB/Swiss-Prot
    Q9JM01, Q9JM02
    UniProtKB/TrEMBL
    A0A8L2R015

  4. XM_063269759.1 → XP_063125829.1  cyclin-dependent kinase-like 3 isoform X7

    UniProtKB/TrEMBL
    A0A8I6GKT9
    Related
    ENSRNOP00000072310.2, ENSRNOT00000079411.3

  5. XM_039086735.2 → XP_038942663.1  cyclin-dependent kinase-like 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZUY6, A0A8I6GKT9
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  6. XM_063269754.1 → XP_063125824.1  cyclin-dependent kinase-like 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZUY6, A0A8I6GKT9

  7. XM_039086737.2 → XP_038942665.1  cyclin-dependent kinase-like 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZUY6, A0A8I6GKT9
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  8. XM_017602529.3 → XP_017458018.1  cyclin-dependent kinase-like 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ABM2
    Related
    ENSRNOP00000091215.1, ENSRNOT00000098640.2
    Conserved Domains (2) summary
    smart00220
    Location:16 → 298
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07846
    Location:14 → 298
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

  9. XM_008773885.4 → XP_008772107.1  cyclin-dependent kinase-like 3 isoform X3

    See identical proteins and their annotated locations for XP_008772107.1

    UniProtKB/TrEMBL
    A0A8I5ZUY6, A0A8I6GKT9
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  10. XM_008773883.4 → XP_008772105.1  cyclin-dependent kinase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_008772105.1

    UniProtKB/TrEMBL
    A0A8I6GKT9
    Conserved Domains (2) summary
    smart00220
    Location:16 → 298
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:14 → 298
    PKc_like; Protein Kinases, catalytic domain

  11. XM_008773886.4 → XP_008772108.1  cyclin-dependent kinase-like 3 isoform X3

    See identical proteins and their annotated locations for XP_008772108.1

    UniProtKB/TrEMBL
    A0A8I5ZUY6, A0A8I6GKT9
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  12. XM_008773884.4 → XP_008772106.1  cyclin-dependent kinase-like 3 isoform X3

    See identical proteins and their annotated locations for XP_008772106.1

    UniProtKB/TrEMBL
    A0A8I5ZUY6, A0A8I6GKT9
    Related
    ENSRNOP00000082633.2, ENSRNOT00000102740.2
    Conserved Domains (1) summary
    cl21453
    Location:2 → 286
    PKc_like; Protein Kinases, catalytic domain

  13. XM_063269756.1 → XP_063125826.1  cyclin-dependent kinase-like 3 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K2N2

  14. XM_039086739.2 → XP_038942667.1  cyclin-dependent kinase-like 3 isoform X11

    Conserved Domains (1) summary
    cl21453
    Location:14 → 298
    PKc_like; Protein Kinases, catalytic domain

  15. XM_063269757.1 → XP_063125827.1  cyclin-dependent kinase-like 3 isoform X6

    UniProtKB/TrEMBL
    A0A0G2K5J4, A0A8L2R015
    Related
    ENSRNOP00000073449.3, ENSRNOT00000085895.3

  16. XM_008773889.4 → XP_008772111.1  cyclin-dependent kinase-like 3 isoform X5

    See identical proteins and their annotated locations for XP_008772111.1

    UniProtKB/TrEMBL
    A0A8I5ZYS3, A0A8I6GKT9
    Related
    ENSRNOP00000084767.2, ENSRNOT00000099737.2
    Conserved Domains (2) summary
    smart00220
    Location:16 → 298
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:14 → 298
    PKc_like; Protein Kinases, catalytic domain

  17. XM_063269758.1 → XP_063125828.1  cyclin-dependent kinase-like 3 isoform X7

    UniProtKB/TrEMBL
    A0A8I6GKT9

  18. XM_063269763.1 → XP_063125833.1  cyclin-dependent kinase-like 3 isoform X9

    UniProtKB/TrEMBL
    A0A8I6GKT9
    Related
    ENSRNOP00000094552.1, ENSRNOT00000120278.2

  19. XM_017602531.3 → XP_017458020.1  cyclin-dependent kinase-like 3 isoform X10

RNA

  1. XR_010055233.1 RNA Sequence

  2. XR_010055235.1 RNA Sequence

  3. XR_010055234.1 RNA Sequence

  4. XR_597993.4 RNA Sequence

  5. XR_005489935.2 RNA Sequence

  6. XR_010055236.1 RNA Sequence

  7. XR_005489936.2 RNA Sequence

  8. XR_010055232.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001174131.1: Suppressed sequence

    Description
    NM_001174131.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JM01.2 GenPept UniProtKB/Swiss-Prot:Q9JM01

Gene LinkOut

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