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TSKS testis specific serine kinase substrate [ Homo sapiens (human) ]

Gene ID: 60385, updated on 24-Nov-2020

Summary

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Official Symbol
TSKSprovided by HGNC
Official Full Name
testis specific serine kinase substrateprovided by HGNC
Primary source
HGNC:HGNC:30719
See related
Ensembl:ENSG00000126467 MIM:608253
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSKS1; TSSKS; STK22S1; PPP1R161
Summary
This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded protein is highest in the testis and down-regulated in testicular cancer. The gene is localized to the region 19q13.3 among the related RAS viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes, which are both involved in tumorigenesis pathways and progression. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 31.5) See more
Orthologs
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Genomic context

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See TSKS in Genome Data Viewer
Location:
19q13.33
Exon count:
11
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49739753..49763328, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50243011..50266587, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr19.5489 Neighboring gene ribosomal protein S9 pseudogene 4 Neighboring gene uncharacterized LOC105372434 Neighboring gene RNA, U6 small nuclear 841, pseudogene Neighboring gene adaptor related protein complex 2 subunit alpha 1 Neighboring gene microRNA 6799

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a novel human testis-specific kinase substrate gene which is downregulated in testicular tumors. Scorilas A, et al. Biochem Biophys Res Commun, 2001 Jul 13. PMID 11444856
  2. Recombinant production of enzymatically active male contraceptive drug target hTSSK2 - Localization of the TSKS domain phosphorylated by TSSK2. Shetty J, et al. Protein Expr Purif, 2016 May. PMID 26777341, Free PMC Article
  3. Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm. Hao Z, et al. Mol Hum Reprod, 2004 Jun. PMID 15044604
  4. TSKS concentrates in spermatid centrioles during flagellogenesis. Xu B, et al. Dev Biol, 2008 Jul 15. PMID 18495105, Free PMC Article
  5. Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiency. Xu B, et al. Dev Biol, 2008 Jul 15. PMID 18533145, Free PMC Article

See all (15) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
centriole IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
centriole IDA
Inferred from Direct Assay
more info
 PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
testis-specific serine kinase substrate
Names
STK22 substrate 1
protein phosphatase 1, regulatory subunit 161
testis specific serine/threonine kinase substrate
testis-specific kinase substrate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021733.2 → NP_068379.1  testis-specific serine kinase substrate

    See identical proteins and their annotated locations for NP_068379.1

    Status: REVIEWED

    Source sequence(s)
    AC011495
    Consensus CDS
    CCDS12780.1
    UniProtKB/Swiss-Prot
    Q9UJT2
    Related
    ENSP00000246801.2, ENST00000246801.8
    Conserved Domains (1) summary
    pfam15358
    Location:26 → 592
    TSKS; Testis-specific serine kinase substrate

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49739753..49763328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527201.1 → XP_011525503.1  testis-specific serine kinase substrate isoform X1

    Conserved Domains (2) summary
    pfam10267
    Location:95 → 241
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
    pfam15358
    Location:26 → 617
    TSKS; Testis-specific serine kinase substrate

  2. XM_011527202.1 → XP_011525504.1  testis-specific serine kinase substrate isoform X2

    Conserved Domains (2) summary
    pfam10267
    Location:95 → 241
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
    pfam15358
    Location:26 → 499
    TSKS; Testis-specific serine kinase substrate

  3. XM_011527203.2 → XP_011525505.1  testis-specific serine kinase substrate isoform X3

    Conserved Domains (2) summary
    pfam10267
    Location:95 → 241
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
    pfam15358
    Location:26 → 541
    TSKS; Testis-specific serine kinase substrate
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UJT2.3 GenPept UniProtKB/Swiss-Prot:Q9UJT2

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