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TSKS testis specific serine kinase substrate [ Homo sapiens (human) ]

Gene ID: 60385, updated on 24-Nov-2020

Summary

Official Symbol
TSKSprovided by HGNC
Official Full Name
testis specific serine kinase substrateprovided by HGNC
Primary source
HGNC:HGNC:30719
See related
Ensembl:ENSG00000126467 MIM:608253
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSKS1; TSSKS; STK22S1; PPP1R161
Summary
This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded protein is highest in the testis and down-regulated in testicular cancer. The gene is localized to the region 19q13.3 among the related RAS viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes, which are both involved in tumorigenesis pathways and progression. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 31.5) See more
Orthologs
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Genomic context

See TSKS in Genome Data Viewer
Location:
19q13.33
Exon count:
11
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49739753..49763328, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50243011..50266587, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr19.5489 Neighboring gene ribosomal protein S9 pseudogene 4 Neighboring gene uncharacterized LOC105372434 Neighboring gene RNA, U6 small nuclear 841, pseudogene Neighboring gene adaptor related protein complex 2 subunit alpha 1 Neighboring gene microRNA 6799

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
centriole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centriole IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
testis-specific serine kinase substrate
Names
STK22 substrate 1
protein phosphatase 1, regulatory subunit 161
testis specific serine/threonine kinase substrate
testis-specific kinase substrate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021733.2NP_068379.1  testis-specific serine kinase substrate

    See identical proteins and their annotated locations for NP_068379.1

    Status: REVIEWED

    Source sequence(s)
    AC011495
    Consensus CDS
    CCDS12780.1
    UniProtKB/Swiss-Prot
    Q9UJT2
    Related
    ENSP00000246801.2, ENST00000246801.8
    Conserved Domains (1) summary
    pfam15358
    Location:26592
    TSKS; Testis-specific serine kinase substrate

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49739753..49763328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527201.1XP_011525503.1  testis-specific serine kinase substrate isoform X1

    Conserved Domains (2) summary
    pfam10267
    Location:95241
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
    pfam15358
    Location:26617
    TSKS; Testis-specific serine kinase substrate
  2. XM_011527202.1XP_011525504.1  testis-specific serine kinase substrate isoform X2

    Conserved Domains (2) summary
    pfam10267
    Location:95241
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
    pfam15358
    Location:26499
    TSKS; Testis-specific serine kinase substrate
  3. XM_011527203.2XP_011525505.1  testis-specific serine kinase substrate isoform X3

    Conserved Domains (2) summary
    pfam10267
    Location:95241
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
    pfam15358
    Location:26541
    TSKS; Testis-specific serine kinase substrate
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