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Lmna lamin A/C [ Rattus norvegicus (Norway rat) ]

Gene ID: 60374, updated on 3-Jun-2018
Official Symbol
Lmnaprovided by RGD
Official Full Name
lamin A/Cprovided by RGD
Primary source
RGD:620456
See related
Ensembl:ENSRNOG00000019638 Vega:OTTRNOG00000002426
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
a component of the nuclear membrane on the nucleoplasmic side or lamina [RGD, Feb 2006]
Expression
Biased expression in Heart (RPKM 472.1), Lung (RPKM 385.2) and 9 other tissues See more
Orthologs
See Lmna in Genome Data Viewer
Location:
2q34
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187842884..187863552, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (207245237..207265928, complement)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene solute carrier family 25, member 44 Neighboring gene semaphorin 4A Neighboring gene mex-3 RNA binding family member A Neighboring gene RAB25, member RAS oncogene family

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase 1 binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular protein localization ISO
Inferred from Sequence Orthology
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
cellular senescence IEP
Inferred from Expression Pattern
more info
PubMed 
establishment or maintenance of microtubule cytoskeleton polarity IEA
Inferred from Electronic Annotation
more info
 
establishment or maintenance of microtubule cytoskeleton polarity ISO
Inferred from Sequence Orthology
more info
 
muscle organ development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of adipose tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cardiac muscle hypertrophy in response to stress IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cardiac muscle hypertrophy in response to stress ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cardiac muscle hypertrophy in response to stress ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
negative regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope organization IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope organization ISO
Inferred from Sequence Orthology
more info
 
nucleus organization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell aging IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell aging ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell aging ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
protein localization to nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
regulation of protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
ventricular cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
ventricular cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
intermediate filament IEA
Inferred from Electronic Annotation
more info
 
lamin filament IEA
Inferred from Electronic Annotation
more info
 
lamin filament ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear lamina IEA
Inferred from Electronic Annotation
more info
 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
prelamin-A/C
Names
lamin A
lamin C2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002016.2NP_001002016.2  prelamin-A/C

    See identical proteins and their annotated locations for NP_001002016.2

    Status: VALIDATED

    Source sequence(s)
    AC119762, CA338388, DN934590, FM031779, FM060776
    UniProtKB/TrEMBL
    G3V8L3
    Related
    ENSRNOP00000026705.4, OTTRNOP00000002366, ENSRNOT00000026705.6, OTTRNOT00000004162
    Conserved Domains (3) summary
    pfam00038
    Location:30386
    Filament; Intermediate filament protein
    pfam00932
    Location:433541
    LTD; Lamin Tail Domain
    cl19219
    Location:297376
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    187842884..187863552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    167884341..167905010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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